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At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
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Diabetologia
Literature
1.
Bierhaus A, Zhang Y, Deng Y et al (1995) Mechanism of the tumor necrosis factor alpha-mediated induction of endothelial tissue factor. J Biol Chem 270:26419–26432PubMedCrossRef
2.
Isermann B, Vinnikov IA, Madhusudhan T et al (2007) Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis. Nat Med 13:1349–1358PubMedCrossRef
3.
Bierhaus A, Schiekofer S, Schwaninger M et al (2001) Diabetes-associated sustained activation of the transcription factor nuclear factor-κB. Diabetes 50:2792–2808PubMedCrossRef
4.
Bierhaus A, Wolf J, Andrassy M et al (2003) A mechanism converting psychosocial stress into mononuclear cell activation. Proc Natl Acad Sci U S A 100:1920–1925PubMedCrossRef
5.
Bierhaus A, Fleming T, Stoyanov S et al (2012) Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy. Nat Med (in press)
6.
Yang H, Hreggvidsdottir HS, Palmblad K et al (2010) A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release. Proc Natl Acad Sci U S A 107:11942–11947PubMedCrossRef
Metadata
Title
Angelika Bierhaus, 1962–2012
Author
P. P. Nawroth
Publication date
01-07-2012
Publisher
Springer-Verlag
Published in
Diabetologia / Issue 7/2012
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-012-2574-5

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Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

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