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Diabetologia
Published in: Diabetologia 7/2012

01-07-2012 | Research Letter

Functional MRI of the hypothalamic response to an oral glucose load

Authors: D. E. Flanagan, J. Fulford, B. Krishnan, A. Benattayallah, A. Watt, I. R. Summers

Published in: Diabetologia | Issue 7/2012

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Excerpt

To the Editor: Functional MRI (fMRI) using a blood oxygen level dependent (BOLD) sequence provides a tool to measure the effects of alterations in blood glucose on the patterns and magnitudes of neuronal activation in the human brain [1]. Previous experiments using a glucose load have suggested that it is possible in humans to identify changes in the BOLD signal from areas within the hypothalamus [2‐6]; however, the results have been contradictory. …
Literature
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Ugurbil K, Hu X, Chen W, Zhu XH, Kim SG, Georgopoulos A (1999) Functional mapping in the human brain using high magnetic fields. Philos Trans R Soc Lond Ser B Biol Sci 354:1195–1213CrossRef
2.
Liu Y, Gao JH, Liu HL, Fox PT (2000) The temporal response of the brain after eating revealed by functional MRI. Nature 405:1058–1062PubMedCrossRef
3.
Matsuda M, Liu Y, Mahankali S et al (1999) Altered hypothalamic function in response to glucose ingestion in obese humans. Diabetes 48:1801–1806PubMedCrossRef
4.
Smeets PA, de Graaf C, Stafleu A, van Osch MJ, van der Grond J (2005) Functional MRI of human hypothalamic responses following glucose ingestion. NeuroImage 24:363–368PubMedCrossRef
5.
Vidarsdottir S, Smeets PA, Eichelsheim DL et al (2007) Glucose ingestion fails to inhibit hypothalamic neuronal activity in patients with type 2 diabetes. Diabetes 56:2547–2550PubMedCrossRef
6.
Smeets PA, Vidarsdottir S, de Graaf C et al (2007) Oral glucose intake inhibits hypothalamic neuronal activity more effectively than glucose infusion. Am J Physiol Endocrinol Metab 293:E754–E758PubMedCrossRef
Metadata
Title
Functional MRI of the hypothalamic response to an oral glucose load
Authors
D. E. Flanagan
J. Fulford
B. Krishnan
A. Benattayallah
A. Watt
I. R. Summers
Publication date
01-07-2012
Publisher
Springer-Verlag
Published in
Diabetologia / Issue 7/2012
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-012-2559-4

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