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Acta Diabetologica

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01-07-2018 | Original Article

An increased waist-to-hip ratio is a key determinant of atherosclerotic burden in overweight subjects

Authors: Roberto Scicali, David Rosenbaum, Antonino Di Pino, Philippe Giral, Philippe Cluzel, Alban Redheuil, Salvatore Piro, Agata Maria Rabuazzo, Francesco Purrello, Eric Bruckert, Antonio Gallo

Published in: Acta Diabetologica | Issue 7/2018

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Abstract

Aims

The association of overweight status and cardiovascular disease is not clear. In this study we aimed to investigate coronary atherosclerotic disease, evaluated as coronary artery calcium score (CACs), in overweight patients with or without abdominal obesity as defined by waist-to-hip ratio (WHR).

Methods

We enrolled 276 patients aged between 40 and 70 years, with a body mass index of 25–29.9 kg/m² and at least one cardiovascular risk factor. Exclusion criteria were history of diabetes, cardiovascular or renal disease. Patients were stratified in high WHR (H-WHR) or low WHR (L-WHR) group according to WHR (≥ 0.85 for women and ≥ 0.90 for men) and underwent multi-detector computed tomography for CACs. Mean carotid intima-media thickness (IMT) and plaque presence were equally assessed.

Results

CACs was higher in the H-WHR group compared to L-WHR (9.05 [0.0–83.48] vs 0.0 [0.0–64.7] AU, p < 0.01); the prevalence of CACs > 0 in the H-WHR group was significantly higher than subjects with L-WHR (59.6% vs 38.5%, p < 0.001). Moreover, H-WHR group had higher mean IMT (0.64 [0.56–0.72] vs 0.59 [0.55–0.67] mm, p < 0.05) and higher carotid plaque prevalence (63.7% vs 50.8%, p < 0.05) compared to subjects with L-WHR. Logistic regression showed that H-WHR was associated with presence of CACs and carotid plaque (p < 0.01). In a multiple linear regression, WHR was positively associated with CACs and IMT (p < 0.01).

Conclusions

H-WHR is a marker of coronary and peripheral atherosclerotic burden in overweight patients.

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Title: An increased waist-to-hip ratio is a key determinant of atherosclerotic burden in overweight subjects
Authors: Roberto Scicali
David Rosenbaum
Antonino Di Pino
Philippe Giral
Philippe Cluzel
Alban Redheuil
Salvatore Piro
Agata Maria Rabuazzo
Francesco Purrello
Eric Bruckert
Antonio Gallo
Publication date: 01-07-2018
Publisher: Springer Milan
Published in: Acta Diabetologica / Issue 7/2018
Print ISSN: 0940-5429
Electronic ISSN: 1432-5233
DOI: https://doi.org/10.1007/s00592-018-1144-9

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