Cerebrospinal fluid MFG-E8 as a promising biomarker of amyotrophic lateral sclerosis

go back to reference Nowicka N, Juranek J, Juranek JK, Wojtkiewicz J (2019) Risk factors and emerging therapies in amyotrophic lateral sclerosis. Int J Mol Sci 20(11):E2616 Nowicka N, Juranek J, Juranek JK, Wojtkiewicz J (2019) Risk factors and emerging therapies in amyotrophic lateral sclerosis. Int J Mol Sci 20(11):E2616

go back to reference Abati E, Bresolin N, Comi G, Corti S (2019) Advances, challenges, and perspectives in translational stem cell therapy for amyotrophic lateral sclerosis. Mol Neurobiol 56(10):6703–6715 Abati E, Bresolin N, Comi G, Corti S (2019) Advances, challenges, and perspectives in translational stem cell therapy for amyotrophic lateral sclerosis. Mol Neurobiol 56(10):6703–6715

go back to reference Lule D, Bohm S, Muller HP, Aho-Ozhan H, Keller J, Gorges M, Loose M, Weishaupt JH, Uttner I, Pinkhardt E, Kassubek J, Del TK, Braak H, Abrahams S, Ludolph AC (2018) Cognitive phenotypes of sequential staging in amyotrophic lateral sclerosis. Cortex. 101:163–171PubMedCrossRef Lule D, Bohm S, Muller HP, Aho-Ozhan H, Keller J, Gorges M, Loose M, Weishaupt JH, Uttner I, Pinkhardt E, Kassubek J, Del TK, Braak H, Abrahams S, Ludolph AC (2018) Cognitive phenotypes of sequential staging in amyotrophic lateral sclerosis. Cortex. 101:163–171PubMedCrossRef

go back to reference Da CS, Bui A, Saberi S, Lee SK, Stauffer J, McAlonis-Downes M, Schulte D, Pizzo DP, Parone PA, Cleveland DW, Ravits J (2017) Misfolded SOD1 is not a primary component of sporadic ALS. Acta Neuropathol 134(1):97–111CrossRef Da CS, Bui A, Saberi S, Lee SK, Stauffer J, McAlonis-Downes M, Schulte D, Pizzo DP, Parone PA, Cleveland DW, Ravits J (2017) Misfolded SOD1 is not a primary component of sporadic ALS. Acta Neuropathol 134(1):97–111CrossRef

go back to reference Floeter MK, Gendron TF (2018) Biomarkers for amyotrophic lateral sclerosis and Frontotemporal dementia associated with hexanucleotide expansion mutations in C9orf72. Front Neurol 9:1063PubMedPubMedCentralCrossRef Floeter MK, Gendron TF (2018) Biomarkers for amyotrophic lateral sclerosis and Frontotemporal dementia associated with hexanucleotide expansion mutations in C9orf72. Front Neurol 9:1063PubMedPubMedCentralCrossRef

go back to reference Pawlitzki M, Schreiber S, Bittner D, Kreipe J, Leypoldt F, Rupprecht K, Carare RO, Meuth SG, Vielhaber S, Kortvelyessy P (2018) CSF neurofilament light chain levels in primary progressive MS: signs of axonal neurodegeneration. Front Neurol 9:1037PubMedPubMedCentralCrossRef Pawlitzki M, Schreiber S, Bittner D, Kreipe J, Leypoldt F, Rupprecht K, Carare RO, Meuth SG, Vielhaber S, Kortvelyessy P (2018) CSF neurofilament light chain levels in primary progressive MS: signs of axonal neurodegeneration. Front Neurol 9:1037PubMedPubMedCentralCrossRef

go back to reference Gonzalez-Garza MT, Martinez HR, Cruz-Vega DE, Hernandez-Torre M, Moreno-Cuevas JE (2018) Adipsin, MIP-1b, and IL-8 as CSF biomarker panels for ALS diagnosis. Dis Markers 2018:3023826PubMedPubMedCentralCrossRef Gonzalez-Garza MT, Martinez HR, Cruz-Vega DE, Hernandez-Torre M, Moreno-Cuevas JE (2018) Adipsin, MIP-1b, and IL-8 as CSF biomarker panels for ALS diagnosis. Dis Markers 2018:3023826PubMedPubMedCentralCrossRef

go back to reference Mishra PS, Vijayalakshmi K, Nalini A, Sathyaprabha TN, Kramer BW, Alladi PA, Raju TR (2017) Etiogenic factors present in the cerebrospinal fluid from amyotrophic lateral sclerosis patients induce predominantly pro-inflammatory responses in microglia. J Neuroinflammation 14(1):251PubMedPubMedCentralCrossRef Mishra PS, Vijayalakshmi K, Nalini A, Sathyaprabha TN, Kramer BW, Alladi PA, Raju TR (2017) Etiogenic factors present in the cerebrospinal fluid from amyotrophic lateral sclerosis patients induce predominantly pro-inflammatory responses in microglia. J Neuroinflammation 14(1):251PubMedPubMedCentralCrossRef

go back to reference Sekizawa T, Openshaw H, Ohbo K, Sugamura K, Itoyama Y, Niland JC (1998) Cerebrospinal fluid interleukin 6 in amyotrophic lateral sclerosis: immunological parameter and comparison with inflammatory and non-inflammatory central nervous system diseases. J Neurol Sci 154(2):194–199PubMedCrossRef Sekizawa T, Openshaw H, Ohbo K, Sugamura K, Itoyama Y, Niland JC (1998) Cerebrospinal fluid interleukin 6 in amyotrophic lateral sclerosis: immunological parameter and comparison with inflammatory and non-inflammatory central nervous system diseases. J Neurol Sci 154(2):194–199PubMedCrossRef

go back to reference Aoki N, Ishii T, Ohira S, Yamaguchi Y, Negi M, Adachi T, Nakamura R, Matsuda T (1997) Stage specific expression of milk fat globule membrane glycoproteins in mouse mammary gland: comparison of MFG-E8, butyrophilin, and CD36 with a major milk protein, beta-casein. Biochim Biophys Acta 1334(2–3):182–190PubMedCrossRef Aoki N, Ishii T, Ohira S, Yamaguchi Y, Negi M, Adachi T, Nakamura R, Matsuda T (1997) Stage specific expression of milk fat globule membrane glycoproteins in mouse mammary gland: comparison of MFG-E8, butyrophilin, and CD36 with a major milk protein, beta-casein. Biochim Biophys Acta 1334(2–3):182–190PubMedCrossRef

go back to reference Xu X, Cai X, Zhu Y, He W, Wu Q, Shi X, Fang Y, Pei Z (2018) MFG-E8 inhibits a beta-induced microglial production of cathelicidin-related antimicrobial peptide: a suitable target against Alzheimer's disease. Cell Immunol 331:59–66PubMedCrossRef Xu X, Cai X, Zhu Y, He W, Wu Q, Shi X, Fang Y, Pei Z (2018) MFG-E8 inhibits a beta-induced microglial production of cathelicidin-related antimicrobial peptide: a suitable target against Alzheimer's disease. Cell Immunol 331:59–66PubMedCrossRef

go back to reference Nakashima Y, Miyagi-Shiohira C, Noguchi H, Omasa T (2018) The healing effect of human milk fat globule-EGF factor 8 protein (MFG-E8) in a rat model of Parkinson's disease. Brain Sci 8(9):E167 Nakashima Y, Miyagi-Shiohira C, Noguchi H, Omasa T (2018) The healing effect of human milk fat globule-EGF factor 8 protein (MFG-E8) in a rat model of Parkinson's disease. Brain Sci 8(9):E167

go back to reference Del CM, Galimberti D, Elias N, Boonkamp L, Pijnenburg YA, van Swieten JC, Watts K, Paciotti S, Beccari T, Hu W, Teunissen CE (2018) Novel CSF biomarkers to discriminate FTLD and its pathological subtypes. Ann Clin Transl Neurol 5(10):1163–1175CrossRef Del CM, Galimberti D, Elias N, Boonkamp L, Pijnenburg YA, van Swieten JC, Watts K, Paciotti S, Beccari T, Hu W, Teunissen CE (2018) Novel CSF biomarkers to discriminate FTLD and its pathological subtypes. Ann Clin Transl Neurol 5(10):1163–1175CrossRef

go back to reference Shi X, Cai X, Di W, Li J, Xu X, Zhang A, Qi W, Zhou Z, Fang Y (2017) MFG-E8 selectively inhibited Abeta-induced microglial M1 polarization via NF-kappaB and PI3K-Akt pathways. Mol Neurobiol 54(10):7777–7788PubMedCrossRef Shi X, Cai X, Di W, Li J, Xu X, Zhang A, Qi W, Zhou Z, Fang Y (2017) MFG-E8 selectively inhibited Abeta-induced microglial M1 polarization via NF-kappaB and PI3K-Akt pathways. Mol Neurobiol 54(10):7777–7788PubMedCrossRef

go back to reference Li J, Xu X, Cai X, Weng Y, Wang Y, Shen Q, Shi X (2019) Milk fat globule-epidermal growth factor-factor 8 reverses lipopolysaccharide-induced microglial oxidative stress. Oxidative Med Cell Longev 2019:2601394 Li J, Xu X, Cai X, Weng Y, Wang Y, Shen Q, Shi X (2019) Milk fat globule-epidermal growth factor-factor 8 reverses lipopolysaccharide-induced microglial oxidative stress. Oxidative Med Cell Longev 2019:2601394

go back to reference Xu X, Zhang A, Zhu Y, He W, Di W, Fang Y, Shi X (2018) MFG-E8 reverses microglial-induced neurotoxic astrocyte (A1) via NF-kappaB and PI3K-Akt pathways. J Cell Physiol 234(1):904–914PubMedCrossRef Xu X, Zhang A, Zhu Y, He W, Di W, Fang Y, Shi X (2018) MFG-E8 reverses microglial-induced neurotoxic astrocyte (A1) via NF-kappaB and PI3K-Akt pathways. J Cell Physiol 234(1):904–914PubMedCrossRef

go back to reference Cunha C, Santos C, Gomes C, Fernandes A, Correia AM, Sebastiao AM, Vaz AR, Brites D (2018) Downregulated glia interplay and increased miRNA-155 as promising markers to track ALS at an early stage. Mol Neurobiol 55(5):4207–4224PubMed Cunha C, Santos C, Gomes C, Fernandes A, Correia AM, Sebastiao AM, Vaz AR, Brites D (2018) Downregulated glia interplay and increased miRNA-155 as promising markers to track ALS at an early stage. Mol Neurobiol 55(5):4207–4224PubMed

go back to reference Vaz AR, Pinto S, Ezequiel C, Cunha C, Carvalho LA, Moreira R, Brites D (2019) Phenotypic effects of wild-type and mutant SOD1 expression in N9 murine microglia at steady state, Inflammatory and Immunomodulatory Conditions. Front Cell Neurosci 13:109PubMedPubMedCentralCrossRef Vaz AR, Pinto S, Ezequiel C, Cunha C, Carvalho LA, Moreira R, Brites D (2019) Phenotypic effects of wild-type and mutant SOD1 expression in N9 murine microglia at steady state, Inflammatory and Immunomodulatory Conditions. Front Cell Neurosci 13:109PubMedPubMedCentralCrossRef

go back to reference Brooks BR, Miller RG, Swash M, Munsat TL (2000) El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord 1(5):293–299PubMedCrossRef Brooks BR, Miller RG, Swash M, Munsat TL (2000) El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord 1(5):293–299PubMedCrossRef

go back to reference Pawlukowska W, Baumert B, Golab-Janowska M, Sobus A, Welnicka A, Meller A, Machowska-Sempruch K, Zawislak A, Luczkowska K, Milczarek S, Osekowska B, Paczkowska E, Rotter I, Nowacki P, Machalinski B (2019) Influence of lineage-negative stem cell therapy on articulatory functions in ALS patients. Stem Cells Int 2019:7213854PubMedPubMedCentralCrossRef Pawlukowska W, Baumert B, Golab-Janowska M, Sobus A, Welnicka A, Meller A, Machowska-Sempruch K, Zawislak A, Luczkowska K, Milczarek S, Osekowska B, Paczkowska E, Rotter I, Nowacki P, Machalinski B (2019) Influence of lineage-negative stem cell therapy on articulatory functions in ALS patients. Stem Cells Int 2019:7213854PubMedPubMedCentralCrossRef

go back to reference Folstein MF, Folstein SE, McHugh PR (1975) "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12(3):189–198CrossRef Folstein MF, Folstein SE, McHugh PR (1975) "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12(3):189–198CrossRef

go back to reference ATS/ERS Statement on respiratory muscle testing. Am J Respir Crit Care Med. 2002; 166(4):518–624 ATS/ERS Statement on respiratory muscle testing. Am J Respir Crit Care Med. 2002; 166(4):518–624

go back to reference Tilanus T, Groothuis JT, TenBroek-Pastoor J, Feuth TB, Heijdra YF, Slenders J, Doorduin J, Van Engelen BG, Kampelmacher MJ, Raaphorst J (2017) The predictive value of respiratory function tests for non-invasive ventilation in amyotrophic lateral sclerosis. Respir Res 18(1):144PubMedPubMedCentralCrossRef Tilanus T, Groothuis JT, TenBroek-Pastoor J, Feuth TB, Heijdra YF, Slenders J, Doorduin J, Van Engelen BG, Kampelmacher MJ, Raaphorst J (2017) The predictive value of respiratory function tests for non-invasive ventilation in amyotrophic lateral sclerosis. Respir Res 18(1):144PubMedPubMedCentralCrossRef

go back to reference Xu Z, Henderson RD, David M, McCombe PA (2016) Neurofilaments as biomarkers for amyotrophic lateral sclerosis: a systematic review and meta-analysis. PLoS One 11(10):e164625 Xu Z, Henderson RD, David M, McCombe PA (2016) Neurofilaments as biomarkers for amyotrophic lateral sclerosis: a systematic review and meta-analysis. PLoS One 11(10):e164625

go back to reference Khalil M, Teunissen CE, Otto M, Piehl F, Sormani MP, Gattringer T, Barro C, Kappos L, Comabella M, Fazekas F, Petzold A, Blennow K, Zetterberg H, Kuhle J (2018) Neurofilaments as biomarkers in neurological disorders. Nat Rev Neurol 14(10):577–589PubMedCrossRef Khalil M, Teunissen CE, Otto M, Piehl F, Sormani MP, Gattringer T, Barro C, Kappos L, Comabella M, Fazekas F, Petzold A, Blennow K, Zetterberg H, Kuhle J (2018) Neurofilaments as biomarkers in neurological disorders. Nat Rev Neurol 14(10):577–589PubMedCrossRef

go back to reference Weydt P, Oeckl P, Huss A, Muller K, Volk AE, Kuhle J, Knehr A, Andersen PM, Prudlo J, Steinacker P, Weishaupt JH, Ludolph AC, Otto M (2016) Neurofilament levels as biomarkers in asymptomatic and symptomatic familial amyotrophic lateral sclerosis. Ann Neurol 79(1):152–158PubMedCrossRef Weydt P, Oeckl P, Huss A, Muller K, Volk AE, Kuhle J, Knehr A, Andersen PM, Prudlo J, Steinacker P, Weishaupt JH, Ludolph AC, Otto M (2016) Neurofilament levels as biomarkers in asymptomatic and symptomatic familial amyotrophic lateral sclerosis. Ann Neurol 79(1):152–158PubMedCrossRef

go back to reference Ganesalingam J, An J, Shaw CE, Shaw G, Lacomis D, Bowser R (2011) Combination of neurofilament heavy chain and complement C3 as CSF biomarkers for ALS. J Neurochem 117(3):528–537PubMedPubMedCentralCrossRef Ganesalingam J, An J, Shaw CE, Shaw G, Lacomis D, Bowser R (2011) Combination of neurofilament heavy chain and complement C3 as CSF biomarkers for ALS. J Neurochem 117(3):528–537PubMedPubMedCentralCrossRef

go back to reference Olney NT, Spina S, Miller BL (2017) Frontotemporal dementia. Neurol Clin 35(2):339–374PubMedPubMedCentralCrossRef Olney NT, Spina S, Miller BL (2017) Frontotemporal dementia. Neurol Clin 35(2):339–374PubMedPubMedCentralCrossRef

go back to reference Lomen-Hoerth C, Anderson T, Miller B (2002) The overlap of amyotrophic lateral sclerosis and frontotemporal dementia. Neurology. 59(7):1077–1079PubMedCrossRef Lomen-Hoerth C, Anderson T, Miller B (2002) The overlap of amyotrophic lateral sclerosis and frontotemporal dementia. Neurology. 59(7):1077–1079PubMedCrossRef

go back to reference Phukan J, Elamin M, Bede P, Jordan N, Gallagher L, Byrne S, Lynch C, Pender N, Hardiman O (2012) The syndrome of cognitive impairment in amyotrophic lateral sclerosis: a population-based study. J Neurol Neurosurg Psychiatry 83(1):102–108PubMedCrossRef Phukan J, Elamin M, Bede P, Jordan N, Gallagher L, Byrne S, Lynch C, Pender N, Hardiman O (2012) The syndrome of cognitive impairment in amyotrophic lateral sclerosis: a population-based study. J Neurol Neurosurg Psychiatry 83(1):102–108PubMedCrossRef

go back to reference Strong MJ, Grace GM, Freedman M, Lomen-Hoerth C, Woolley S, Goldstein LH, Murphy J, Shoesmith C, Rosenfeld J, Leigh PN, Bruijn L, Ince P, Figlewicz D (2009) Consensus criteria for the diagnosis of frontotemporal cognitive and behavioural syndromes in amyotrophic lateral sclerosis. Amyotroph Lateral Scler 10(3):131–146PubMedCrossRef Strong MJ, Grace GM, Freedman M, Lomen-Hoerth C, Woolley S, Goldstein LH, Murphy J, Shoesmith C, Rosenfeld J, Leigh PN, Bruijn L, Ince P, Figlewicz D (2009) Consensus criteria for the diagnosis of frontotemporal cognitive and behavioural syndromes in amyotrophic lateral sclerosis. Amyotroph Lateral Scler 10(3):131–146PubMedCrossRef

go back to reference DeJesus-Hernandez M, Mackenzie IR, Boeve BF, Boxer AL, Baker M, Rutherford NJ, Nicholson AM, Finch NA, Flynn H, Adamson J, Kouri N, Wojtas A, Sengdy P, Hsiung GY, Karydas A, Seeley WW et al (2011) Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS. Neuron. 72(2):245–256PubMedPubMedCentralCrossRef DeJesus-Hernandez M, Mackenzie IR, Boeve BF, Boxer AL, Baker M, Rutherford NJ, Nicholson AM, Finch NA, Flynn H, Adamson J, Kouri N, Wojtas A, Sengdy P, Hsiung GY, Karydas A, Seeley WW et al (2011) Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS. Neuron. 72(2):245–256PubMedPubMedCentralCrossRef

go back to reference Cirulli ET, Lasseigne BN, Petrovski S, Sapp PC, Dion PA, Leblond CS, Couthouis J, Lu YF, Wang Q, Krueger BJ, Ren Z, Keebler J, Han Y, Levy SE, Boone BE, Wimbish JR, Waite LL, Jones AL, Carulli JP, Day-Williams AG, Staropoli JF, Xin WW, Chesi A, Raphael AR, McKenna-Yasek D, Cady J, Vianney de Jong JMB, Kenna KP, Smith BN, Topp S, Miller J, Gkazi A, FALS Sequencing Consortium, al-Chalabi A, van den Berg LH, Veldink J, Silani V, Ticozzi N, Shaw CE, Baloh RH, Appel S, Simpson E, Lagier-Tourenne C, Pulst SM, Gibson S, Trojanowski JQ, Elman L, McCluskey L, Grossman M, Shneider NA, Chung WK, Ravits JM, Glass JD, Sims KB, van Deerlin VM, Maniatis T, Hayes SD, Ordureau A, Swarup S, Landers J, Baas F, Allen AS, Bedlack RS, Harper JW, Gitler AD, Rouleau GA, Brown R, Harms MB, Cooper GM, Harris T, Myers RM, Goldstein DB (2015) Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways. Science. 347(6229):1436–1441PubMedPubMedCentralCrossRef Cirulli ET, Lasseigne BN, Petrovski S, Sapp PC, Dion PA, Leblond CS, Couthouis J, Lu YF, Wang Q, Krueger BJ, Ren Z, Keebler J, Han Y, Levy SE, Boone BE, Wimbish JR, Waite LL, Jones AL, Carulli JP, Day-Williams AG, Staropoli JF, Xin WW, Chesi A, Raphael AR, McKenna-Yasek D, Cady J, Vianney de Jong JMB, Kenna KP, Smith BN, Topp S, Miller J, Gkazi A, FALS Sequencing Consortium, al-Chalabi A, van den Berg LH, Veldink J, Silani V, Ticozzi N, Shaw CE, Baloh RH, Appel S, Simpson E, Lagier-Tourenne C, Pulst SM, Gibson S, Trojanowski JQ, Elman L, McCluskey L, Grossman M, Shneider NA, Chung WK, Ravits JM, Glass JD, Sims KB, van Deerlin VM, Maniatis T, Hayes SD, Ordureau A, Swarup S, Landers J, Baas F, Allen AS, Bedlack RS, Harper JW, Gitler AD, Rouleau GA, Brown R, Harms MB, Cooper GM, Harris T, Myers RM, Goldstein DB (2015) Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways. Science. 347(6229):1436–1441PubMedPubMedCentralCrossRef

go back to reference Freischmidt A, Wieland T, Richter B, Ruf W, Schaeffer V, Muller K, Marroquin N, Nordin F, Hubers A, Weydt P, Pinto S, Press R, Millecamps S, Molko N, Bernard E, Desnuelle C et al (2015) Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia. Nat Neurosci 18(5):631–636PubMedCrossRef Freischmidt A, Wieland T, Richter B, Ruf W, Schaeffer V, Muller K, Marroquin N, Nordin F, Hubers A, Weydt P, Pinto S, Press R, Millecamps S, Molko N, Bernard E, Desnuelle C et al (2015) Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia. Nat Neurosci 18(5):631–636PubMedCrossRef

go back to reference Renton AE, Majounie E, Waite A, Simon-Sanchez J, Rollinson S, Gibbs JR, Schymick JC, Laaksovirta H, van Swieten JC, Myllykangas L, Kalimo H, Paetau A, Abramzon Y, Remes AM, Kaganovich A, Scholz SW et al (2011) A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD. Neuron. 72(2):257–268PubMedPubMedCentralCrossRef Renton AE, Majounie E, Waite A, Simon-Sanchez J, Rollinson S, Gibbs JR, Schymick JC, Laaksovirta H, van Swieten JC, Myllykangas L, Kalimo H, Paetau A, Abramzon Y, Remes AM, Kaganovich A, Scholz SW et al (2011) A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD. Neuron. 72(2):257–268PubMedPubMedCentralCrossRef

go back to reference Chio A, Hammond ER, Mora G, Bonito V, Filippini G (2015) Development and evaluation of a clinical staging system for amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 86(1):38–44PubMedCrossRef Chio A, Hammond ER, Mora G, Bonito V, Filippini G (2015) Development and evaluation of a clinical staging system for amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 86(1):38–44PubMedCrossRef

go back to reference Ahn SW, Kim SH, Kim JE, Kim SM, Kim SH, Sung JJ, Lee KW, Hong YH (2011) Frontal assessment battery to evaluate frontal lobe dysfunction in ALS patients. Can J Neurol Sci 38(2):242–246PubMedCrossRef Ahn SW, Kim SH, Kim JE, Kim SM, Kim SH, Sung JJ, Lee KW, Hong YH (2011) Frontal assessment battery to evaluate frontal lobe dysfunction in ALS patients. Can J Neurol Sci 38(2):242–246PubMedCrossRef

go back to reference Oskarsson B, Quan D, Rollins YD, Neville HE, Ringel SP, Arciniegas DB (2010) Using the frontal assessment battery to identify executive function impairments in amyotrophic lateral sclerosis: a preliminary experience. Amyotroph Lateral Scler 11(1–2):244–247PubMedCrossRef Oskarsson B, Quan D, Rollins YD, Neville HE, Ringel SP, Arciniegas DB (2010) Using the frontal assessment battery to identify executive function impairments in amyotrophic lateral sclerosis: a preliminary experience. Amyotroph Lateral Scler 11(1–2):244–247PubMedCrossRef

go back to reference Plastiras SC, Karadimitrakis SP, Ziakas PD, Vlachoyiannopoulos PG, Moutsopoulos HM, Tzelepis GE (2006) Scleroderma lung: initial forced vital capacity as predictor of pulmonary function decline. Arthritis Rheum 55(4):598–602PubMedCrossRef Plastiras SC, Karadimitrakis SP, Ziakas PD, Vlachoyiannopoulos PG, Moutsopoulos HM, Tzelepis GE (2006) Scleroderma lung: initial forced vital capacity as predictor of pulmonary function decline. Arthritis Rheum 55(4):598–602PubMedCrossRef

go back to reference Lechtzin N, Cudkowicz ME, de Carvalho M, Genge A, Hardiman O, Mitsumoto H, Mora JS, Shefner J, Van den Berg LH, Andrews JA (2018) Respiratory measures in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener 19(5–6):321–330PubMedCrossRef Lechtzin N, Cudkowicz ME, de Carvalho M, Genge A, Hardiman O, Mitsumoto H, Mora JS, Shefner J, Van den Berg LH, Andrews JA (2018) Respiratory measures in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener 19(5–6):321–330PubMedCrossRef

go back to reference Gendron TF, Daughrity LM, Heckman MG, Diehl NN, Wuu J, Miller TM, Pastor P, Trojanowski JQ, Grossman M, Berry JD, Hu WT, Ratti A, Benatar M, Silani V, Glass JD, Floeter MK, Jeromin A, Boylan KB, Petrucelli L, the C9ORF72 Neurofilament Study Group (2017) Phosphorylated neurofilament heavy chain: a biomarker of survival for C9ORF72-associated amyotrophic lateral sclerosis. Ann Neurol 82(1):139–146PubMedPubMedCentralCrossRef Gendron TF, Daughrity LM, Heckman MG, Diehl NN, Wuu J, Miller TM, Pastor P, Trojanowski JQ, Grossman M, Berry JD, Hu WT, Ratti A, Benatar M, Silani V, Glass JD, Floeter MK, Jeromin A, Boylan KB, Petrucelli L, the C9ORF72 Neurofilament Study Group (2017) Phosphorylated neurofilament heavy chain: a biomarker of survival for C9ORF72-associated amyotrophic lateral sclerosis. Ann Neurol 82(1):139–146PubMedPubMedCentralCrossRef