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Published in: Acta Neurologica Belgica 3/2017

Open Access 01-09-2017 | Review

Alzheimer’s disease CSF biomarkers: clinical indications and rational use

Authors: Ellis Niemantsverdriet, Sara Valckx, Maria Bjerke, Sebastiaan Engelborghs

Published in: Acta Neurologica Belgica | Issue 3/2017

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Abstract

This review focusses on the validation and standardization of Alzheimer’s disease (AD) cerebrospinal fluid (CSF) biomarkers, as well as on the current clinical indications and rational use of CSF biomarkers in daily clinical practice. The validated AD CSF biomarkers, Aβ1-42, T-tau, and P-tau181, have an added value in the (differential) diagnosis of AD and related disorders, including mixed pathologies, atypical presentations, and in case of ambiguous clinical dementia diagnosis. CSF biomarkers should not be routinely used in the diagnostic work-up of dementia and cannot be used to diagnose non-AD dementias. In cognitively healthy subjects, CSF biomarkers can only be applied for research purposes, e.g., to identify pre-clinical AD in the context of clinical trials with potentially disease-modifying drugs. Therefore, biomarker-based early diagnosis of AD offers great opportunities for preventive treatment development in the near future.
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Metadata
Title
Alzheimer’s disease CSF biomarkers: clinical indications and rational use
Authors
Ellis Niemantsverdriet
Sara Valckx
Maria Bjerke
Sebastiaan Engelborghs
Publication date
01-09-2017
Publisher
Springer International Publishing
Published in
Acta Neurologica Belgica / Issue 3/2017
Print ISSN: 0300-9009
Electronic ISSN: 2240-2993
DOI
https://doi.org/10.1007/s13760-017-0816-5

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