Transient IgG deficiency with lesions in brain and spinal cord: a mimicker of common variable immunodeficiency syndrome

Excerpt

Patients with immune deficiency states often present with clinical perplexing disease processes, especially involving lesions of the central nervous system (CNS). Common variable immune deficiency (CVID) is a rare primary immune deficiency disorder that is usually associated with multi-organ reversible inflammatory granulomatous lesions, though rarely present with CNS manifestations. CNS involvement in CVID can mimic neuroinflammatory disorders such as neurosarcoidosis clinically, radiographically, and on biopsy of granulomatous lesions [1]. Such lesions have not yet been described in patients with transient IgG deficiency. We present an interesting case of transient IgG deficiency that mimicked partially reversible sarcoid-like lesions of the CNS. …