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Open Access 01-12-2021 | Alkaloids | Review

Flavonoids, alkaloids and saponins: are these plant-derived compounds an alternative to the treatment of rheumatoid arthritis? A literature review

Authors: Luis Ângelo Macedo Santiago, Roberval Nascimento Moraes Neto, Ana Caroline Santos Ataíde, Dâmaris Cristina Sousa Carvalho Fonseca, Enio Fernandes Aragão Soares, Joicy Cortez de Sá Sousa, Renata Mondego-Oliveira, Rachel Melo Ribeiro, Maria do Socorro de Sousa Cartágenes, Lídio Gonçalves Lima-Neto, Rafael Cardoso Carvalho, Eduardo Martins de Sousa

Published in: Clinical Phytoscience | Issue 1/2021

Abstract

Rheumatoid arthritis (RA) is a systemic inflammatory disease characterized by synovial inflammation leading to progressive joint erosion and, eventually, joint deformities. RA treatment includes anti-inflammatories, corticosteroids, synthetic disease-modifying antirheumatic drugs (DMARDs), and immunosuppressants. Drug administration is associated with adverse reactions, as gastrointestinal ulcers, cardiovascular complications, and opportunistic infections. Wherefore, different plant-derived phytochemical compounds are studied like new therapeutic approach to treatment of RA. Among the phytochemical compounds of plants for treatment of RA, flavonoids, alkaloids and saponins are related for present anti-inflammatory activity and act as physiological and metabolic regulators. They have low toxicity compared to other active plant compounds, so their therapeutic properties are widely studied. The intention of the review is to present an overview of the therapeutics of flavonoids, alkaloids, and saponins for RA. An extensive literature survey was undertaken through different online platforms:

PubMed, SciELO, and Virtual Health Library databases, to identify phytochemical compounds used in RA treatment and the descriptors used were medicinal plants, herbal medicines, and rheumatoid arthritis. Seventy-five research and review articles were found to be apt for inclusion into the review. The present study summarizes the phytochemicals isolated from plants that have therapeutic effects on RA models, in vitro and in vivo. The studied substances exerted anti-inflammatory, chondroprotective, immunoregulatory, anti-angiogenic, and antioxidant activities and the most compounds possess good therapeutic properties, valuable for further research for treatment of RA.

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Title: Flavonoids, alkaloids and saponins: are these plant-derived compounds an alternative to the treatment of rheumatoid arthritis? A literature review
Authors: Luis Ângelo Macedo Santiago
Roberval Nascimento Moraes Neto
Ana Caroline Santos Ataíde
Dâmaris Cristina Sousa Carvalho Fonseca
Enio Fernandes Aragão Soares
Joicy Cortez de Sá Sousa
Renata Mondego-Oliveira
Rachel Melo Ribeiro
Maria do Socorro de Sousa Cartágenes
Lídio Gonçalves Lima-Neto
Rafael Cardoso Carvalho
Eduardo Martins de Sousa
Publication date: 01-12-2021
Publisher: Springer Berlin Heidelberg
Keywords: Alkaloids
Alkaloids
Rheumatoid Arthritis
Published in: Clinical Phytoscience / Issue 1/2021
Electronic ISSN: 2199-1197
DOI: https://doi.org/10.1186/s40816-021-00291-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Flavonoids, alkaloids and saponins: are these plant-derived compounds an alternative to the treatment of rheumatoid arthritis? A literature review

Abstract

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Springer Medicine

Abstract

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