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10-02-2024 | Albuminuria | Original Article

Impaired sensitivity to thyroid hormones is associated with albuminuria in the euthyroid population: results from NHANES

Authors: Zhaoxiang Wang, Menghuan Wu, Tao Pan, Xuelin Zhao, Li Zhang, Fengyan Tang, Ying Pan, Bing Lu, Shao Zhong, Song Bai

Published in: Hormones

Abstract

Purpose

The relationship between thyroid hormone sensitivity and albuminuria remains unclear. We aimed to investigate the association between thyroid hormone sensitivity and the risk of albuminuria in a euthyroid population.

Methods

This cross-sectional study included 7634 euthyroid adults collected from the National Health and Nutrition Examination Survey (NHANES) between 2007 and 2012. Central sensitivity to thyroid hormones was evaluated using the thyroid-stimulating hormone index (TSHI), the thyrotrophic thyroxine resistance index (TT4RI), and the thyroid feedback quantile-based index (TFQI). Peripheral sensitivity to thyroid hormones was measured using the free triiodothyronine/free thyroxine (FT3/FT4) ratio. Furthermore, the independent relationship between sensitivity to thyroid hormones and albuminuria was assessed.

Results

The proportion of albuminuria increased with a higher interquartile range of TFQI levels (7.31% vs. 7.89% vs. 7.95% vs. 9.89%, P = 0.024). Furthermore, TFQI was found to be independently associated with the risk of albuminuria after adjusting for confounding factors (OR = 1.28, 95% CI 1.01–1.60, P = 0.037). Subgroup analysis revealed a significant relationship between TFQI and albuminuria, especially among individuals over 60.

Conclusions

In euthyroid subjects, impaired central sensitivity to thyroid hormones is associated with albuminuria. TFQI holds significant potential as an epidemiological tool for quantifying the impact of impaired central sensitivity on the risk of albuminuria.

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Title: Impaired sensitivity to thyroid hormones is associated with albuminuria in the euthyroid population: results from NHANES
Authors: Zhaoxiang Wang
Menghuan Wu
Tao Pan
Xuelin Zhao
Li Zhang
Fengyan Tang
Ying Pan
Bing Lu
Shao Zhong
Song Bai
Publication date: 10-02-2024
Publisher: Springer International Publishing
Keyword: Albuminuria
Published in: Hormones
Print ISSN: 1109-3099
Electronic ISSN: 2520-8721
DOI: https://doi.org/10.1007/s42000-024-00533-2

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