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Respiratory Research
Published in: Respiratory Research 5/2001

Open Access 01-10-2001 | Commentary

Airway obstruction in asthma: does the response to a deep inspiration matter?

Author: Jeffrey J Fredberg

Published in: Respiratory Research | Issue 5/2001

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Abstract

Airway hyperresponsiveness in asthma may not be a problem of too much airway smooth muscle strength. Rather, it may be a problem of too little of the factors that oppose muscle shortening. The weight of available evidence seems to support the idea that loss of the dilating response to a deep inspiration may play a central role in this process, and that the locus of the response is within the airway smooth muscle cell. Bridge dynamics and plastic reorganization of the smooth muscle cytoskeleton are the focus of this commentary; how these factors interact and details about underlying mechanisms remain unclear.
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Metadata
Title
Airway obstruction in asthma: does the response to a deep inspiration matter?
Author
Jeffrey J Fredberg
Publication date
01-10-2001
Publisher
BioMed Central
Published in
Respiratory Research / Issue 5/2001
Electronic ISSN: 1465-993X
DOI
https://doi.org/10.1186/rr68

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