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Respiratory Research
Published in: Respiratory Research 5/2001

Open Access 01-10-2001 | Review

Role of free radicals in the pathogenesis of acute chest syndrome in sickle cell disease

Authors: Elizabeth S Klings, Harrison W Farber

Published in: Respiratory Research | Issue 5/2001

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Abstract

Acute chest syndrome (ACS) of sickle cell disease (SCD) is characterized pathologically by vaso-occlusive processes that result from abnormal interactions between sickle red blood cells (RBCs), white blood cells (WBCs) and/or platelets, and the vascular endothelium. One potential mechanism of vascular damage in ACS is by generation of oxygen-related molecules, such as superoxide (O2-), hydrogen peroxide (H2O2), peroxynitrite (ONOO-), and the hydroxyl (•OH) radical. The present review summarizes the evidence for alterations in oxidant stress during ACS of SCD, and the potential contributions of RBCs, WBCs and the vascular endothelium to this process.
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Metadata
Title
Role of free radicals in the pathogenesis of acute chest syndrome in sickle cell disease
Authors
Elizabeth S Klings
Harrison W Farber
Publication date
01-10-2001
Publisher
BioMed Central
Published in
Respiratory Research / Issue 5/2001
Electronic ISSN: 1465-993X
DOI
https://doi.org/10.1186/rr70

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