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01-12-2020 | Mood Disorders | Original Article

Anxiety and depression in adult-onset Still’s disease patients and associations with health-related quality of life

Authors: Huihui Chi, Haiyan Jin, Zhihong Wang, Tienan Feng, Ting Zeng, Hui Shi, Xinyao Wu, Liyan Wan, Jialin Teng, Yue Sun, Honglei Liu, Xiaobing Cheng, Junna Ye, Qiongyi Hu, Zhuochao Zhou, Jieyu Gu, Jinchao Jia, Tingting Liu, Xin Qiao, Chengde Yang, Yutong Su

Published in: Clinical Rheumatology | Issue 12/2020

Abstract

Objective

Adult-onset Still’s disease (AOSD) is an autoinflammatory disorder leading to multiorgan involvements. We sought to investigate mood status and the health-related quality of life (HRQoL) in these patients.

Methods

In this study, 82 AOSD patients and 82 age- and sex-matched healthy controls were included. Demographic and clinical data of recruited patients were collected. The Hospital Anxiety and Depression Scale (HADS) and Medical Outcomes Survey Short Form-36 (SF-36) were used to evaluate the mood status and quality of life, respectively. Spearman correlation and multivariable linear regression analyses were used to assess the disease-related risk factors associated with anxiety and depression.

Results

Forty-four active and thirty-eight relieved patients were enrolled. We found that scores of both HADS anxiety (HADS-A) and depression (HADS-D) subscales in active AOSD were significantly higher than inactive patients, which were significantly higher than controls. Moreover, the HADS-A was positively correlated to the patient’s global assessment (PGA), pain, and dosage of prednisone, and the HADS-D was positively correlated to systemic score, PGA, and pain. Female, high dosage of corticosteroids, and PGA more than 50 had a significant association with HADS-A score, while the sore throat and PGA more than 50 had a significant association with HADS-D score. Furthermore, AOSD patients’ anxiety and depression had a negative impact on HRQoL.

Conclusion

Active AOSD patients tended to be anxious and depressed, suffering from poorer HRQoL compared to patients in remission. Therefore, the evaluation of mental health and HRQoL should be included in AOSD patients’ long-term management.

Key Points

• Adult-onset Still’s disease (AOSD) is a systemic inflammatory disorder leading to multiorgan involvement. This study was so far the first published research focuses on AOSD patients’ mental involvement and health-related quality of life (HRQoL).

• Active AOSD patients were more tended to be anxious and depressive and suffered from poorer HRQoL compared to inactive patients.

• Patients’ anxiety and depression were associated with impaired HRQoL.

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Title: Anxiety and depression in adult-onset Still’s disease patients and associations with health-related quality of life
Authors: Huihui Chi
Haiyan Jin
Zhihong Wang
Tienan Feng
Ting Zeng
Hui Shi
Xinyao Wu
Liyan Wan
Jialin Teng
Yue Sun
Honglei Liu
Xiaobing Cheng
Junna Ye
Qiongyi Hu
Zhuochao Zhou
Jieyu Gu
Jinchao Jia
Tingting Liu
Xin Qiao
Chengde Yang
Yutong Su
Publication date: 01-12-2020
Publisher: Springer International Publishing
Keywords: Mood Disorders
Affective Disorder
Sore Throat
Anxiety
Published in: Clinical Rheumatology / Issue 12/2020
Print ISSN: 0770-3198
Electronic ISSN: 1434-9949
DOI: https://doi.org/10.1007/s10067-020-05094-4

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