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Journal of Nuclear Cardiology
Published in: Journal of Nuclear Cardiology 4/2016

01-08-2016 | Original Article

Adopting new gamma cameras and reconstruction algorithms: Do we need to re-establish normal reference values?

Authors: Timothy L. Miao, BSc, Vinay Kansal, BHSc, R. Glenn Wells, PhD, Iftikhar Ali, MD, Terrence D. Ruddy, MD, FRCPC, FACC, Benjamin J. W. Chow, MD, FRCPC, FACC, FASNC, FSCCT

Published in: Journal of Nuclear Cardiology | Issue 4/2016

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Abstract

Background

The impact of adopting new single photon emission computed tomography (SPECT) cameras and new reconstruction algorithms on left ventricular (LV) volumes has not been well established. We sought to understand the impact of hardware and software changes on normal LV reference ranges.

Methods

Consecutive patients who underwent stress Tc-99m tetrofosmin 8-frame gated SPECT MPI were screened. Patients with a history of myocardial infarction, coronary revascularization, abnormal MPI, or known LV dysfunction/reduced ejection fraction were excluded. A total of 1953 consecutive normal patients, with rest LV end-diastolic volume (EDV) and end-systolic volume (ESV) measurements were analyzed. After stratifying according to sex, LV volumes indexed to body surface area were compared across the different gamma cameras.

Results

In a normal population, measurements with CZT were different from those obtained by the dual-headed NaI gamma cameras for LV EDVi (men: 53.6 ± 10.4 vs 48.3 ± 10.2 mL/m2 and women: 43.3 ± 8.9 vs 37.8 ± 9.3 mL/m2; P < 0.001) and LV ESVi (men: 21.7 ± 7.0 vs 16.9 ± 6.2 mL/m2 and women: 13.4 ± 5.3 vs 10.6 ± 4.7 mL/m2; P < 0.001). Inter- and intra-observer reliability for all measures was excellent. These findings were verified in a prospectively collected cohort. A sub-analysis of LV measurements comparing new resolution recovery and standard reconstruction software revealed no significant differences in LV measures.

Conclusion

This study demonstrates that normal references ranges of LV volumes vary between SPECT cameras and confirms the need for establishing reference values that are camera specific.
Literature
1.
White HD, Norris RM, Brown MA, Brandt PW, Whitlock RM, Wild CJ. Left ventricular end-systolic volume as the major determinant of survival after recovery from myocardial infarction. Circulation 1987;76:44–51.CrossRefPubMed
2.
Hamer AW, Takayama M, Abraham KA, Roche AH, Kerr AR, Williams BF, et al. End-systolic volume and long-term survival after coronary artery bypass graft surgery in patients with impaired left ventricular function. Circulation 1994;90:2899–904.CrossRefPubMed
3.
McManus DD, Shah SJ, Fabi MR, Rosen A, Whooley MA, Schiller NB. Prognostic value of left ventricular end-systolic volume index as a predictor of heart failure hospitalization in stable coronary artery disease: Data from the Heart and Soul Study. J Am Soc Echocardiogr 2009;22:190–7.CrossRefPubMed
4.
Hammermeister KE, DeRouen TA, Dodge HT. Variables predictive of survival in patients with coronary disease. Selection by univariate and multivariate analyses from the clinical, electrocardiographic, exercise, arteriographic, and quantitative angiographic evaluations. Circulation 1979;59:421–30.CrossRefPubMed
5.
Mazzanti M, Germano G, Kiat H, Kavanagh PB, Alexanderson E, Friedman JD, et al. Identification of severe and extensive coronary artery disease by automatic measurement of transient ischemic dilation of the left ventricle in dual-isotope myocardial perfusion SPECT. J Am Coll Cardiol 1996;27:1612–20.CrossRefPubMed
6.
Abidov A, Bax JJ, Hayes SW, Hachamovitch R, Cohen I, Gerlach J, et al. Transient ischemic dilation ratio of the left ventricle is a significant predictor of future cardiac events in patients with otherwise normal myocardial perfusion SPECT. J Am Coll Cardiol 2003;42:1818–25.CrossRefPubMed
7.
Garcia EV, Faber TL, Esteves FP. Cardiac dedicated ultrafast SPECT cameras: New designs and clinical implications. J Nucl Med 2011;52:210–7.CrossRefPubMed
8.
Depuey EG, Mahmarian JJ, Miller TD, Einstein AJ, Hansen CL, Holly TA, et al. Patient-centered imaging. J Nucl Cardiol 2012;19:185–215.CrossRefPubMed
9.
Gebhard C, Stähli BE, Gebhard CE, Fiechter M, Fuchs TA, Stehli J, et al. Gender- and age-related differences in rest and post-stress left ventricular cardiac function determined by gated SPECT. Int J Cardiovasc Imaging 2014;30:1191–9.CrossRefPubMed
10.
Véra P, Manrique A, Pontvianne V, Hitzel A, Koning R, Cribier A. Thallium-gated SPECT in patients with major myocardial infarction: Effect of filtering and zooming in comparison with equilibrium radionuclide imaging and left ventriculography. J Nucl Med 1999;40:513–21.PubMed
11.
Salihin Yusoff MN, Zakaria A. Determination of the optimum filter for qualitative and quantitative 99mTc myocardial SPECT imaging. Iran J Radiat Res 2009;6:173–81.
12.
13.
Lum DP, Coel MN. Comparison of automatic quantification software for the measurement of ventricular volume and ejection fraction in gated myocardial perfusion SPECT. Nucl Med Commun 2003;24:259–66.CrossRefPubMed
14.
Jensen MM, Schmidt U, Huang C, Zerahn B. Gated tomographic radionuclide angiography using cadmium-zinc-telluride detector gamma camera; comparison to traditional gamma cameras. J Nucl Cardiol 2014;21:384–96.CrossRefPubMed
15.
Bocher M, Shrem Y. A fast cardiac gamma camera with dynamic SPECT capabilities: Design, system validation and future potential. Eur J Nucl Med Mol Imaging 2010;37:1887–902.CrossRefPubMedPubMedCentral
16.
Enevoldsen LH, Menashi CA, Andersen UB, Jensen LT, Henriksen OM. Effects of acquisition time and reconstruction algorithm on image quality, quantitative parameters, and clinical interpretation of myocardial perfusion imaging. J Nucl Cardiol 2013;20:1086–92.CrossRefPubMed
17.
Mosteller RD. Simplified calculation of body-surface area. N Engl J Med 1987;317:1098.PubMed
18.
Hansen CL, Goldstein RA, Akinboboye OO, Berman DS, Botvinick EH, Churchwell KB, et al. Myocardial perfusion and function: Single photon emission computed tomography. J Nucl Cardiol 2007;14:e39–60.CrossRefPubMed
19.
Ali I, Ruddy TD, Almgrahi A, Anstett FG, Wells RG. Half-time SPECT myocardial perfusion imaging with attenuation correction. J Nucl Med 2009;50:554–62.CrossRefPubMed
20.
Esteves FP, Raggi P, Folks RD, Keidar Z, Askew JW, Rispler S, et al. Novel solid-state-detector dedicated cardiac camera for fast myocardial perfusion imaging: Multicenter comparison with standard dual detector cameras. J Nucl Cardiol 2009;16:927–34.CrossRefPubMedPubMedCentral
21.
Go V, Bhatt MR, Hendel RC. The diagnostic and prognostic value of ECG-gated SPECT myocardial perfusion imaging. J Nucl Med 2004;45:912–21.PubMed
22.
Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, et al. American Society of Echocardiography’s Nomenclature and Standards Committee; Task Force on Chamber Quantification; American College of Cardiology Echocardiography Committee; American Heart Association; European Association of Echocardiography, European Society of Cardiology. Recommendations for chamber quantification. Eur J Echocardiogr 2006;7:79–108.CrossRefPubMed
23.
Maceira AM, Prasad SK, Khan M, Pennell DJ. Normalized left ventricular systolic and diastolic function by steady state free precession cardiovascular magnetic resonance. J Cardiovasc Magn Reson 2006;8:417–26.CrossRefPubMed
24.
Stojanovska J, Prasitdumrong H, Patel S, Sundaram B, Gross BH, Yilmaz ZN, et al. Reference absolute and indexed values for left and right ventricular volume, function and mass from cardiac computed tomography. J Med Imaging Radiat Oncol 2014;58:547–58.CrossRefPubMed
25.
Hedeer F, Palmer J, Arheden H, Ugander M. Gated myocardial perfusion SPECT underestimates left ventricular volumes and shows high variability compared to cardiac magnetic resonance imaging—a comparison of four different commercial automated software packages. BMC Med Imaging 2010;10:10.CrossRefPubMedPubMedCentral
26.
Schepis T, Gaemperli O, Koepfli P, Valenta I, Strobel K, Brunner A, et al. Comparison of 64-slice CT with gated SPECT for evaluation of left ventricular function. J Nucl Med 2006;47:1288–94.PubMed
27.
Hambye AS, Vervaet A, Dobbeleir A. Variability of left ventricular ejection fraction and volumes with quantitative gated SPECT: Influence of algorithm, pixel size and reconstruction parameters in small and normal-sized hearts. Eur J Nucl Med Mol Imaging 2004;31:1606–13.CrossRefPubMed
28.
Duvall WL, Croft LB, Godiwala T, Ginsberg E, George T, Henzlova MJ. Reduced isotope dose with rapid SPECT MPI imaging: Initial experience with a CZT SPECT camera. J Nucl Cardiol 2010;17:1009–14.CrossRefPubMed
29.
DePuey EG, Ata P, Wray R, Friedman M. Very low-activity stress/high-activity rest, single-day myocardial perfusion SPECT with a conventional sodium iodide camera and wide beam reconstruction processing. J Nucl Cardiol 2012;19:931–44.CrossRefPubMed
30.
Nakajima K, Higuchi T, Taki J, Kawano M, Tonami N. Accuracy of ventricular volume and ejection fraction measured by gated myocardial SPECT: Comparison of 4 software programs. J Nucl Med 2001;42:1571–8.PubMed
Metadata
Title
Adopting new gamma cameras and reconstruction algorithms: Do we need to re-establish normal reference values?
Authors
Timothy L. Miao, BSc
Vinay Kansal, BHSc
R. Glenn Wells, PhD
Iftikhar Ali, MD
Terrence D. Ruddy, MD, FRCPC, FACC
Benjamin J. W. Chow, MD, FRCPC, FACC, FASNC, FSCCT
Publication date
01-08-2016
Publisher
Springer US
Published in
Journal of Nuclear Cardiology / Issue 4/2016
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI
https://doi.org/10.1007/s12350-015-0172-x

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