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AIDS and Behavior
Published in: AIDS and Behavior 8/2019

01-08-2019 | Original Paper

Adherence to Antiretroviral Therapy Among Incarcerated Persons with HIV: Associations with Methadone and Perceived Safety

Authors: Gabriel J. Culbert, Agung Waluyo, Melinda Wang, Tissa Aulia Putri, Alexander R. Bazazi, Frederick L. Altice

Published in: AIDS and Behavior | Issue 8/2019

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Abstract

With adequate support, people with HIV (PWH) may achieve high levels of adherence to antiretroviral therapy (ART) during incarceration. We examined factors associated with ART utilization and adherence among incarcerated PWH (N = 150) in Indonesia. ART utilization was positively associated with HIV status disclosure (adjusted odds ratio [aOR] = 5.5, 95% CI 1.2–24.1, p = 0.023), drug dependency (aOR = 3.9, 95% CI 1.2–12.6, p = 0.022), health service satisfaction (aOR = 3.2, 95% CI 1.7–6.2, p < 0.001), and perceived need for medical treatment (aOR = 1.6, 95% CI 1.1–2.5, p = 0.011), and negatively associated with chance locus of control (aOR = 0.3, 95% CI 0.1–0.7, p = 0.013). Most participants utilizing ART (74.5%) reported less than “perfect” ART adherence. ART adherence was independently associated with perceived personal safety (β = 0.21, 95% CI 0.01–0.40, p = 0.032) and methadone utilization (β = 0.84, 95% CI 0.10–1.67, p = 0.047). PWH receiving methadone had a sixfold higher adjusted odds of being highly-adherent to ART (aOR = 6.3, 95% CI 1.1–35.7, p = 0.036). Interventions that increase methadone utilization and personal safety may improve ART adherence among incarcerated PWH.
Literature
1.
Dolan K, Wirtz AL, Moazen B, Ndeffo-mbah M, Galvani A, Kinner SA, et al. Global burden of HIV, viral hepatitis, and tuberculosis in prisoners and detainees. Lancet. 2016;388(10049):1089–102.CrossRefPubMed
2.
Rich JD, Beckwith CG, Macmadu A, Marshall BDL, Brinkley-Rubinstein L, Amon JJ, et al. Clinical care of incarcerated people with HIV, viral hepatitis, or tuberculosis. Lancet. 2016;388(10049):1103–14.CrossRefPubMedPubMedCentral
3.
Wohl DA, Stephenson BL, Golin CE, Kiziah CN, Rosen D, Ngo B, et al. Adherence to directly observed antiretroviral therapy among human immunodeficiency virus—infected prison inmates. Clin Infect Dis. 2003;36(12):1572–6.CrossRefPubMed
4.
Young JD, Patel M, Badowski M, Mackesy-Amiti ME, Vaughn P, Shicker L, et al. Improved virologic suppression with HIV subspecialty care in a large prison system using telemedicine: an observational study with historical controls. Clin Infect Dis. 2014;59(1):123–6.CrossRefPubMedPubMedCentral
5.
Meyer JP, Cepeda J, Wu J, Trestman RL, Altice FL, Springer SA. Optimization of human immunodeficiency virus treatment during incarceration: viral suppression at the prison gate. JAMA Intern Med. 2014;174(5):721–9.CrossRefPubMedPubMedCentral
6.
Uthman OA, Oladimeji O, Nduka C. Adherence to antiretroviral therapy among HIV-infected prisoners: a systematic review and meta-analysis. AIDS Care. 2017;29(4):489–97.CrossRefPubMed
7.
Fu JJ, Bazazi AR, Altice FL, Mohamed MN, Kamarulzaman A. Absence of antiretroviral therapy and other risk factors for morbidity and mortality in Malaysian compulsory drug detention and rehabilitation centers. PLoS ONE. 2012;7(9):e44249.CrossRefPubMedPubMedCentral
8.
Azbel L, Wickersham JA, Grishaev Y, Dvoryak S, Altice FL. Burden of infectious diseases, substance use disorders, and mental illness among Ukrainian prisoners transitioning to the community. PLoS ONE. 2013;8(3):e59643.CrossRefPubMedPubMedCentral
9.
Telisinghe L, Charalambous S, Topp SM, Herce ME, Hoffmann CJ, Barron P, et al. HIV and tuberculosis in prisons in sub-Saharan Africa. Lancet. 2016;388(10050):1215–27.CrossRefPubMedPubMedCentral
10.
Culbert GJ, Crawford FW, Murni A, Waluyo A, Bazazi AR, Sahar J, et al. Predictors of mortality within prison and after release among persons living with HIV in Indonesia. Res Rep Trop Med. 2017;8:25–35.CrossRefPubMedPubMedCentral
11.
Nachega JB, Sam-Agudu NA, Mofenson LM, Schechter M, Mellors JW. Achieving viral suppression in 90% of people living with human immunodeficiency virus on antiretroviral therapy in low- and middle-income countries: progress, challenges, and opportunities. Clin Infect Dis. 2018;66(10):1487–91.CrossRefPubMed
12.
Fazel S, Bains P, Doll H. Substance abuse and dependence in prisoners: a systematic review. Addiction. 2006;101(2):181–91.CrossRefPubMed
13.
Bick J, Culbert G, Al-Darraji HA, Koh C, Pillai V, Kamarulzaman A, et al. Healthcare resources are inadequate to address the burden of illness among HIV-infected male prisoners in Malaysia. Int J Prison Health. 2016;12(4):253–69.CrossRefPubMed
14.
Muessig KE, Rosen DL, Farel CE, White BL, Filene EJ, Wohl DA. “Inside these fences is our own little world”: prison-based hiv testing and hiv-related stigma among incarcerated men and women. AIDS Educ Prev. 2016;28(2):103–16.CrossRefPubMedPubMedCentral
15.
Hinduan ZR, Suherman H, Pinxten WJ, Alisjahbana B, Hospers HJ. HIV-related knowledge and attitudes among Indonesian prison officers. Int J Prison Health. 2013;9(2):92–102.CrossRefPubMed
16.
17.
Shalihu N, Pretorius L, van Dyk A, Vander Stoep A, Hagopian A. Namibian prisoners describe barriers to HIV antiretroviral therapy adherence. AIDS Care. 2014;26(8):968–75.CrossRefPubMed
18.
Culbert GJ, Waluyo A, Iriyanti M, Muchransyah AP, Kamarulzaman A, Altice FL. Within-prison drug injection among HIV-infected male prisoners in Indonesia: a highly constrained choice. Drug Alcohol Depend. 2015;149:71–9.CrossRefPubMedPubMedCentral
19.
Izenberg JM, Bachireddy C, Wickersham JA, Soule M, Kiriazova T, Dvoriak S, et al. Within-prison drug injection among HIV-infected Ukrainian prisoners: prevalence and correlates of an extremely high-risk behaviour. Int J Drug Policy. 2014;25(5):845–52.CrossRefPubMedPubMedCentral
20.
Milloy MJ, Kerr T, Buxton J, Rhodes T, Guillemi S, Hogg R, et al. Dose-response effect of incarceration events on nonadherence to HIV antiretroviral therapy among injection drug users. J Infect Dis. 2011;203(9):1215–21.CrossRefPubMedPubMedCentral
21.
Loeliger KB, Altice FL, Desai MM, Ciarleglio MM, Gallagher C, Meyer JP. Predictors of linkage to HIV care and viral suppression after release from jails and prisons: a retrospective cohort study. Lancet HIV. 2018;5(2):e96–106.CrossRefPubMed
22.
Joint United Nations Programme on HIV/AIDS. The Gap Report. Geneva: UNAIDS, 2014.
23.
Morineau G, Bollen LJ, Syafitri RI, Nurjannah N, Mustikawati DE, Magnani R. HIV prevalence and risk behaviours among injecting drug users in six indonesian cities implications for future HIV prevention programs. Harm Reduct J. 2012;9(1):37.CrossRefPubMedPubMedCentral
24.
25.
Nelwan EJ, Van Crevel R, Alisjahbana B, Indrati AK, Dwiyana RF, Nuralam N, et al. Human immunodeficiency virus, hepatitis B and hepatitis C in an Indonesian prison: prevalence, risk factors and implications of HIV screening. Trop Med Int Health. 2010;15(12):1491–8.CrossRefPubMed
26.
Nelwan EJ, Isa A, Alisjahbana B, Triani N, Djamaris I, Djaja I, et al. Routine or targeted HIV screening of Indonesian prisoners. Int J Prison Health. 2016;12(1):17–26.CrossRefPubMed
27.
Nelwan EJ, Indrati AK, Isa A, Triani N, Alam NN, Herlan MS, et al. Effect of HIV prevention and treatment program on HIV and HCV transmission and HIV mortality at an Indonesian narcotic prison. Southeast Asian J Trop Med Public Health. 2015;46(5):880–91.PubMed
28.
Gelberg L, Andersen RM, Leake BD. The behavioral model for vulnerable populations: application to medical care use and outcomes for homeless people. Health Serv Res. 2000;34(6):1273–302.PubMedPubMedCentral
29.
Rhodes T. The ‘risk environment’: a framework for understanding and reducing drug-related harm. Int J Drug Policy. 2002;13(2):85–94.CrossRef
30.
Altice FL, Azbel L, Stone J, Brooks-Pollock E, Smyrnov P, Dvoriak S, et al. The perfect storm: incarceration and the high-risk environment perpetuating transmission of HIV, hepatitis C virus, and tuberculosis in Eastern Europe and Central Asia. Lancet. 2016;388(10050):1228–48.CrossRefPubMedPubMedCentral
31.
Althoff AL, Zelenev A, Meyer JP, Fu J, Brown SE, Vagenas P, et al. Correlates of retention in HIV care after release from jail: results from a multi-site study. AIDS Behav. 2013;17(Suppl 2):S156–70.CrossRefPubMed
32.
Strathdee SA, Beletsky L, Kerr T. HIV, drugs and the legal environment. Int J Drug Policy. 2015;26:S27–32.CrossRefPubMed
33.
Booth RE, Dvoryak S, Sung-Joon M, Brewster JT, Wendt WW, Corsi KF, et al. Law enforcement practices associated with HIV infection among injection drug users in Odessa, Ukraine. AIDS Behav. 2013;17(8):2604–14.CrossRefPubMedPubMedCentral
34.
Strathdee SA, Hallett TB, Bobrova N, Rhodes T, Booth R, Abdool R, et al. HIV and risk environment for injecting drug users: the past, present, and future. Lancet. 2010;376(9737):268–84.CrossRefPubMedPubMedCentral
35.
Rhodes T. Risk environments and drug harms: a social science for harm reduction approach. Int J Drug Policy. 2009;20(3):193–201.CrossRefPubMed
36.
Culbert GJ, Williams AB. Cultural adaptation of a medication adherence intervention with prisoners living with HIV in Indonesia: a pragmatic approach to intervention development. J Assoc Nurses AIDS Care. 2018;29(3):454–65.CrossRefPubMed
37.
Williams AB, Burgess JD, Danvers K, Malone J, Winfield SD, Saunders L. Kitchen table wisdom: a Freirian approach to medication adherence. J Assoc Nurses AIDS Care. 2005;16(1):3–12.CrossRefPubMed
38.
Degroot AM, Dannenburg L, Vanhell JG. Forward and backward word translation by bilinguals. J Mem Lang. 1994;33(5):600–29.CrossRef
39.
Chatfield A, Javetski G, Lesh N. CommCare Evidence Base. Dimagi; 2013.
40.
Flaming A, Canty M, Javetski G, Lesh N. The CommCare evidence base for frontline workers. 2015.
41.
Feldman BJ, Fredericksen RJ, Crane PK, Safren SA, Mugavero MJ, Willig JH, et al. Evaluation of the single-item self-rating adherence scale for use in routine clinical care of people living with HIV. AIDS Behav. 2013;17(1):307–18.CrossRefPubMedPubMedCentral
42.
Culbert GJ, Earnshaw VA, Swasti Wulanyani NM, Wegman MP, Waluyo A, Altice FL. Correlates and experiences of HIV stigma in prisoners living with HIV in Indonesia: a mixed-method analysis. J Assoc Nurses AIDS Care. 2015;26(6):743–57.CrossRefPubMedPubMedCentral
43.
Wallston KA, Strudler Wallston B, DeVellis R. Development of the multidimensional health locus of control (MHLC) scales. Health Educ Monogr. 1978;6(1):160–70.CrossRefPubMed
44.
Wallston KA. The validity of the multidimensional health locus of control scales. J Health Psychol. 2005;10(5):623–31.CrossRefPubMed
45.
Institute of Behavioral Research. Texas Christian University Drug Screen V. Fort Worth: Texas Christian University, Institute of Behavioral Research; 2014.
46.
Cortes A, Hunt N, McHale S. Development of the scale of perceived social support in HIV (PSS-HIV). AIDS Behav. 2014;18(12):2274–84.CrossRefPubMed
47.
Holzemer WL, Henry SB, Nokes KM, Corless IB, Brown MA, Powell-Cope GM, et al. Validation of the sign and symptom check-list for persons with HIV disease (SSC-HIV). J Adv Nurs. 1999;30(5):1041–9.CrossRefPubMed
48.
Wickersham JA, Azar MM, Cannon CM, Altice FL, Springer SA. Validation of a brief measure of opioid dependence: the rapid opioid dependence screen (RODS). J Correct Health Care. 2015;21(1):12–26.CrossRefPubMedPubMedCentral
49.
Lazzarini Z, Altice FL. A review of the legal and ethical issues for the conduct of HIV-related research in prisons. AIDS Public Policy J. 2000;15(3–4):105–35.PubMed
50.
Degenhardt L, Mathers BM, Wirtz AL, Wolfe D, Kamarulzaman A, Carrieri MP, et al. What has been achieved in HIV prevention, treatment and care for people who inject drugs, 2010–2012? A review of the six highest burden countries. Int J Drug Policy. 2014;25(1):53–60.CrossRefPubMed
51.
Levi J, Raymond A, Pozniak A, Vernazza P, Kohler P, Hill A. Can the UNAIDS 90-90-90 target be achieved? A systematic analysis of national HIV treatment cascades. BMJ Glob Health. 2016;1(2):e000010.CrossRefPubMedPubMedCentral
52.
Joint United Nations Programme on HIV/AIDS. Country Snapshot 2018: Indonesia. UNAIDS Regional Support Team for Asia and the Pacific and AIDS Data Hub: 2018.
53.
Gardner EM, Burman WJ, Steiner JF, Anderson PL, Bangsberg DR. Antiretroviral medication adherence and the development of class-specific antiretroviral resistance. AIDS (Lond, Engl). 2009;23(9):1035.CrossRef
54.
Culbert GJ, Bazazi AR, Waluyo A, Murni A, Muchransyah AP, Iriyanti M, et al. The influence of medication attitudes on utilization of antiretroviral therapy (ART) in Indonesian prisons. AIDS Behav. 2016;20(5):1026–38.CrossRefPubMedPubMedCentral
55.
Altice FL, Mostashari F, Friedland GH. Trust and the acceptance of and adherence to antiretroviral therapy. J Acquir Immune Defic Syndr. 2001;28(1):47–58.CrossRefPubMed
56.
Low AJ, Mburu G, Welton NJ, May MT, Davies CF, French C, et al. Impact of opioid substitution therapy on antiretroviral therapy outcomes: a systematic review and meta-analysis. Clin Infect Dis. 2016;26:1094.CrossRef
57.
Larney S, Dolan K. A literature review of international implementation of opioid substitution treatment in prisons: equivalence of care? Eur Addict Res. 2009;15(2):107–12.CrossRefPubMed
58.
White BL, Golin CE, Grodensky CA, Kiziah CN, Richardson A, Hudgens MG, et al. Effect of directly observed antiretroviral therapy compared to self-administered antiretroviral therapy on adherence and virological outcomes among HIV-infected prisoners: a randomized controlled pilot study. AIDS Behav. 2015;19(1):128–36.CrossRefPubMedPubMedCentral
59.
Roberts T, Cohn J, Bonner K, Hargreaves S. Scale-up of routine viral load testing in resource-poor settings: current and future implementation challenges. Clin Infect Dis. 2016;62(8):1043–8.CrossRefPubMedPubMedCentral
60.
Gray RT, Reyes J, Nadjib M, Harimurti P, Wilson DP. Assessment of the allocation of HIV funding in Indonesia. World Bank; 2012.
61.
Kouyoumdjian FG, McIsaac KE, Liauw J, Green S, Karachiwalla F, Siu W, et al. A systematic review of randomized controlled trials of interventions to improve the health of persons during imprisonment and in the year after release. Am J Public Health. 2015;105(4):e13–33.CrossRefPubMedPubMedCentral
62.
Metadata
Title
Adherence to Antiretroviral Therapy Among Incarcerated Persons with HIV: Associations with Methadone and Perceived Safety
Authors
Gabriel J. Culbert
Agung Waluyo
Melinda Wang
Tissa Aulia Putri
Alexander R. Bazazi
Frederick L. Altice
Publication date
01-08-2019
Publisher
Springer US
Published in
AIDS and Behavior / Issue 8/2019
Print ISSN: 1090-7165
Electronic ISSN: 1573-3254
DOI
https://doi.org/10.1007/s10461-018-2344-6

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Keynote webinar | Spotlight on medication adherence

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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