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Annals of Intensive Care

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Open Access 01-12-2021 | Acute Respiratory Distress-Syndrome | Research

Individualization of PEEP and tidal volume in ARDS patients with electrical impedance tomography: a pilot feasibility study

Authors: Tobias Becher, Valerie Buchholz, Daniel Hassel, Timo Meinel, Dirk Schädler, Inéz Frerichs, Norbert Weiler

Published in: Annals of Intensive Care | Issue 1/2021

Abstract

Background

In mechanically ventilated patients with acute respiratory distress syndrome (ARDS), electrical impedance tomography (EIT) provides information on alveolar cycling and overdistension as well as assessment of recruitability at the bedside. We developed a protocol for individualization of positive end-expiratory pressure (PEEP) and tidal volume (V_T) utilizing EIT-derived information on recruitability, overdistension and alveolar cycling. The aim of this study was to assess whether the EIT-based protocol allows individualization of ventilator settings without causing lung overdistension, and to evaluate its effects on respiratory system compliance, oxygenation and alveolar cycling.

Methods

20 patients with ARDS were included. Initially, patients were ventilated according to the recommendations of the ARDS Network with a V_T of 6 ml per kg predicted body weight and PEEP adjusted according to the lower PEEP/FiO₂ table. Subsequently, ventilator settings were adjusted according to the EIT-based protocol once every 30 min for a duration of 4 h. To assess global overdistension, we determined whether lung stress and strain remained below 27 mbar and 2.0, respectively.

Results

Prospective optimization of mechanical ventilation with EIT led to higher PEEP levels (16.5 [14–18] mbar vs. 10 [8–10] mbar before optimization; p = 0.0001) and similar V_T (5.7 ± 0.92 ml/kg vs. 5.8 ± 0.47 ml/kg before optimization; p = 0.96). Global lung stress remained below 27 mbar in all patients and global strain below 2.0 in 19 out of 20 patients. Compliance remained similar, while oxygenation was significantly improved and alveolar cycling was reduced after EIT-based optimization.

Conclusions

Adjustment of PEEP and V_T using the EIT-based protocol led to individualization of ventilator settings with improved oxygenation and reduced alveolar cycling without promoting global overdistension.

Trial registrationThis study was registered at clinicaltrials.gov (NCT02703012) on March 9, 2016 before including the first patient.

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Title: Individualization of PEEP and tidal volume in ARDS patients with electrical impedance tomography: a pilot feasibility study
Authors: Tobias Becher
Valerie Buchholz
Daniel Hassel
Timo Meinel
Dirk Schädler
Inéz Frerichs
Norbert Weiler
Publication date: 01-12-2021
Publisher: Springer International Publishing
Keyword: Acute Respiratory Distress-Syndrome
Published in: Annals of Intensive Care / Issue 1/2021
Electronic ISSN: 2110-5820
DOI: https://doi.org/10.1186/s13613-021-00877-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Individualization of PEEP and tidal volume in ARDS patients with electrical impedance tomography: a pilot feasibility study

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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