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Published in: Intensive Care Medicine 6/2009

01-06-2009 | Physiological and Technical Notes

Bedside estimation of recruitable alveolar collapse and hyperdistension by electrical impedance tomography

Authors: Eduardo L. V. Costa, João Batista Borges, Alexandre Melo, Fernando Suarez-Sipmann, Carlos Toufen Jr, Stephan H. Bohm, Marcelo B. P. Amato

Published in: Intensive Care Medicine | Issue 6/2009

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Abstract

Objective

To present a novel algorithm for estimating recruitable alveolar collapse and hyperdistension based on electrical impedance tomography (EIT) during a decremental positive end-expiratory pressure (PEEP) titration.

Design

Technical note with illustrative case reports.

Setting

Respiratory intensive care unit.

Patient

Patients with acute respiratory distress syndrome.

Interventions

Lung recruitment and PEEP titration maneuver.

Measurements and results

Simultaneous acquisition of EIT and X-ray computerized tomography (CT) data. We found good agreement (in terms of amount and spatial location) between the collapse estimated by EIT and CT for all levels of PEEP. The optimal PEEP values detected by EIT for patients 1 and 2 (keeping lung collapse <10%) were 19 and 17 cmH2O, respectively. Although pointing to the same non-dependent lung regions, EIT estimates of hyperdistension represent the functional deterioration of lung units, instead of their anatomical changes, and could not be compared directly with static CT estimates for hyperinflation.

Conclusions

We described an EIT-based method for estimating recruitable alveolar collapse at the bedside, pointing out its regional distribution. Additionally, we proposed a measure of lung hyperdistension based on regional lung mechanics.
Literature
1.
go back to reference Tremblay LN, Slutsky AS (1998) Ventilator-induced injury: from barotrauma to biotrauma. Proc Assoc Am Physicians 110:482–488PubMed Tremblay LN, Slutsky AS (1998) Ventilator-induced injury: from barotrauma to biotrauma. Proc Assoc Am Physicians 110:482–488PubMed
2.
go back to reference Plötz FB, Slutsky AS, van Vught AJ, Heijnen CJ (2004) Ventilator-induced lung injury and multiple system organ failure: a critical review of facts and hypotheses. Intensive Care Med 30:1865–1872PubMedCrossRef Plötz FB, Slutsky AS, van Vught AJ, Heijnen CJ (2004) Ventilator-induced lung injury and multiple system organ failure: a critical review of facts and hypotheses. Intensive Care Med 30:1865–1872PubMedCrossRef
3.
go back to reference ARDSNet (2000) Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The acute respiratory distress syndrome network. N Engl J Med 342:1301–1308CrossRef ARDSNet (2000) Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The acute respiratory distress syndrome network. N Engl J Med 342:1301–1308CrossRef
4.
go back to reference Amato MBP, Barbas CS, Medeiros DM, Magaldi RB, Schettino GP, Lorenzi-Filho G, Kairalla RA, Deheinzelin D, Munoz C, Oliveira R, Takagaki TY, Carvalho CR (1998) Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome. N Engl J Med 338:347–354PubMedCrossRef Amato MBP, Barbas CS, Medeiros DM, Magaldi RB, Schettino GP, Lorenzi-Filho G, Kairalla RA, Deheinzelin D, Munoz C, Oliveira R, Takagaki TY, Carvalho CR (1998) Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome. N Engl J Med 338:347–354PubMedCrossRef
5.
go back to reference Villar J, Kacmarek RM, Pérez-Méndez L, Aguirre-Jaime A (2006) A high positive end-expiratory pressure, low tidal volume ventilatory strategy improves outcome in persistent acute respiratory distress syndrome: a randomized, controlled trial. Crit Care Med 34:1311–1318PubMedCrossRef Villar J, Kacmarek RM, Pérez-Méndez L, Aguirre-Jaime A (2006) A high positive end-expiratory pressure, low tidal volume ventilatory strategy improves outcome in persistent acute respiratory distress syndrome: a randomized, controlled trial. Crit Care Med 34:1311–1318PubMedCrossRef
6.
go back to reference Ranieri VM, Suter PM, Tortorella C, De Tullio R, Dayer JM, Brienza A, Bruno F, Slutsky AS (1999) Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial. JAMA 282:54–61PubMedCrossRef Ranieri VM, Suter PM, Tortorella C, De Tullio R, Dayer JM, Brienza A, Bruno F, Slutsky AS (1999) Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial. JAMA 282:54–61PubMedCrossRef
7.
go back to reference Suarez-Sipmann F, Böhm SH, Tusman G, Pesch T, Thamm O, Reissmann H, Reske A, Magnusson A, Hedenstierna G (2007) Use of dynamic compliance for open lung positive end-expiratory pressure titration in an experimental study. Crit Care Med 35:214–221PubMedCrossRef Suarez-Sipmann F, Böhm SH, Tusman G, Pesch T, Thamm O, Reissmann H, Reske A, Magnusson A, Hedenstierna G (2007) Use of dynamic compliance for open lung positive end-expiratory pressure titration in an experimental study. Crit Care Med 35:214–221PubMedCrossRef
8.
go back to reference Borges JB, Carvalho CRR, Amato MBP (2006) Lung recruitment in patients with ards. N Engl J Med 355:319–320 (author reply 321–322)PubMedCrossRef Borges JB, Carvalho CRR, Amato MBP (2006) Lung recruitment in patients with ards. N Engl J Med 355:319–320 (author reply 321–322)PubMedCrossRef
9.
go back to reference Borges JB, Okamoto VN, Matos GFJ, Caramez MPR, Arantes PR, Barros F, Souza CE, Victorino JA, Kacmarek RM, Barbas CSV, Carvalho CRR, Amato MBP (2006) Reversibility of lung collapse and hypoxemia in early acute respiratory distress syndrome. Am J Respir Crit Care Med 174:268–278PubMedCrossRef Borges JB, Okamoto VN, Matos GFJ, Caramez MPR, Arantes PR, Barros F, Souza CE, Victorino JA, Kacmarek RM, Barbas CSV, Carvalho CRR, Amato MBP (2006) Reversibility of lung collapse and hypoxemia in early acute respiratory distress syndrome. Am J Respir Crit Care Med 174:268–278PubMedCrossRef
10.
go back to reference Terragni PP, Rosboch G, Tealdi A, Corno E, Menaldo E, Davini O, Gandini G, Herrmann P, Mascia L, Quintel M, Slutsky AS, Gattinoni L, Ranieri VM (2007) Tidal hyperinflation during low tidal volume ventilation in acute respiratory distress syndrome. Am J Respir Crit Care Med 175:160–166PubMedCrossRef Terragni PP, Rosboch G, Tealdi A, Corno E, Menaldo E, Davini O, Gandini G, Herrmann P, Mascia L, Quintel M, Slutsky AS, Gattinoni L, Ranieri VM (2007) Tidal hyperinflation during low tidal volume ventilation in acute respiratory distress syndrome. Am J Respir Crit Care Med 175:160–166PubMedCrossRef
11.
go back to reference Grasso S, Stripoli T, De Michele M, Bruno F, Moschetta M, Angelelli G, Munno I, Ruggiero V, Anaclerio R, Cafarelli A, Driessen B, Fiore T (2007) Ardsnet ventilatory protocol and alveolar hyperinflation: role of positive end-expiratory pressure. Am J Respir Crit Care Med 176:761–767PubMedCrossRef Grasso S, Stripoli T, De Michele M, Bruno F, Moschetta M, Angelelli G, Munno I, Ruggiero V, Anaclerio R, Cafarelli A, Driessen B, Fiore T (2007) Ardsnet ventilatory protocol and alveolar hyperinflation: role of positive end-expiratory pressure. Am J Respir Crit Care Med 176:761–767PubMedCrossRef
12.
go back to reference Victorino JA, Borges JB, Okamoto VN, Matos GFJ, Tucci MR, Caramez MPR, Tanaka H, Sipmann FS, Santos DCB, Barbas CSV, Carvalho CRR, Amato MBP (2004) Imbalances in regional lung ventilation: a validation study on electrical impedance tomography. Am J Respir Crit Care Med 169:791–800PubMedCrossRef Victorino JA, Borges JB, Okamoto VN, Matos GFJ, Tucci MR, Caramez MPR, Tanaka H, Sipmann FS, Santos DCB, Barbas CSV, Carvalho CRR, Amato MBP (2004) Imbalances in regional lung ventilation: a validation study on electrical impedance tomography. Am J Respir Crit Care Med 169:791–800PubMedCrossRef
13.
go back to reference Frerichs I, Hinz J, Herrmann P, Weisser G, Hahn G, Dudykevych T, Quintel M, Hellige G (2002) Detection of local lung air content by electrical impedance tomography compared with electron beam ct. J Appl Physiol 93:660–666PubMed Frerichs I, Hinz J, Herrmann P, Weisser G, Hahn G, Dudykevych T, Quintel M, Hellige G (2002) Detection of local lung air content by electrical impedance tomography compared with electron beam ct. J Appl Physiol 93:660–666PubMed
14.
go back to reference Frerichs I, Hahn G, Schiffmann H, Berger C, Hellige G (1999) Monitoring regional lung ventilation by functional electrical impedance tomography during assisted ventilation. Ann NY Acad Sci 873:493–505PubMedCrossRef Frerichs I, Hahn G, Schiffmann H, Berger C, Hellige G (1999) Monitoring regional lung ventilation by functional electrical impedance tomography during assisted ventilation. Ann NY Acad Sci 873:493–505PubMedCrossRef
15.
go back to reference Adler A, Amyot R, Guardo R, Bates JH, Berthiaume Y (1997) Monitoring changes in lung air and liquid volumes with electrical impedance tomography. J Appl Physiol 83:1762–1767PubMed Adler A, Amyot R, Guardo R, Bates JH, Berthiaume Y (1997) Monitoring changes in lung air and liquid volumes with electrical impedance tomography. J Appl Physiol 83:1762–1767PubMed
16.
go back to reference Hickling KG (2001) Best compliance during a decremental, but not incremental, positive end-expiratory pressure trial is related to open-lung positive end-expiratory pressure: a mathematical model of acute respiratory distress syndrome lungs. Am J Respir Crit Care Med 163:69–78PubMed Hickling KG (2001) Best compliance during a decremental, but not incremental, positive end-expiratory pressure trial is related to open-lung positive end-expiratory pressure: a mathematical model of acute respiratory distress syndrome lungs. Am J Respir Crit Care Med 163:69–78PubMed
17.
go back to reference Frazer DG, Weber KC, Franz GN (1985) Evidence of sequential opening and closing of lung units during inflation-deflation of excised rat lungs. Respir Physiol 61:277–288PubMedCrossRef Frazer DG, Weber KC, Franz GN (1985) Evidence of sequential opening and closing of lung units during inflation-deflation of excised rat lungs. Respir Physiol 61:277–288PubMedCrossRef
18.
go back to reference Bersten AD (1998) Measurement of overinflation by multiple linear regression analysis in patients with acute lung injury. Eur Respir J 12:526–532PubMedCrossRef Bersten AD (1998) Measurement of overinflation by multiple linear regression analysis in patients with acute lung injury. Eur Respir J 12:526–532PubMedCrossRef
19.
go back to reference Hedenstierna G, Tokics L, Strandberg A, Lundquist H, Brismar B (1986) Correlation of gas exchange impairment to development of atelectasis during anaesthesia and muscle paralysis. Acta Anaesthesiol Scand 30:183–191PubMedCrossRef Hedenstierna G, Tokics L, Strandberg A, Lundquist H, Brismar B (1986) Correlation of gas exchange impairment to development of atelectasis during anaesthesia and muscle paralysis. Acta Anaesthesiol Scand 30:183–191PubMedCrossRef
20.
go back to reference Frerichs I, Hahn G, Hellige G (1996) Gravity-dependent phenomena in lung ventilation determined by functional EIT. Physiol Meas 17(Suppl 4A):A149–A157PubMedCrossRef Frerichs I, Hahn G, Hellige G (1996) Gravity-dependent phenomena in lung ventilation determined by functional EIT. Physiol Meas 17(Suppl 4A):A149–A157PubMedCrossRef
21.
go back to reference Simon BA, Christensen GE, Low DA, Reinhardt JM (2005) Computed tomography studies of lung mechanics. Proc Am Thorac Soc 2(517–521):506–507 Simon BA, Christensen GE, Low DA, Reinhardt JM (2005) Computed tomography studies of lung mechanics. Proc Am Thorac Soc 2(517–521):506–507
22.
go back to reference Gattinoni L, Pelosi P, Vitale G, Pesenti A, D’Andrea L, Mascheroni D (1991) Body position changes redistribute lung computed-tomographic density in patients with acute respiratory failure. Anesthesiology 74:15–23PubMedCrossRef Gattinoni L, Pelosi P, Vitale G, Pesenti A, D’Andrea L, Mascheroni D (1991) Body position changes redistribute lung computed-tomographic density in patients with acute respiratory failure. Anesthesiology 74:15–23PubMedCrossRef
23.
go back to reference Frerichs I, Dargaville PA, Dudykevych T, Rimensberger PC (2003) Electrical impedance tomography: a method for monitoring regional lung aeration and tidal volume distribution? Intensive Care Med 29:2312–2316PubMedCrossRef Frerichs I, Dargaville PA, Dudykevych T, Rimensberger PC (2003) Electrical impedance tomography: a method for monitoring regional lung aeration and tidal volume distribution? Intensive Care Med 29:2312–2316PubMedCrossRef
24.
go back to reference Meier T, Luepschen H, Karsten J, Leibecke T, Großherr M, Gehring H, Leonhardt S (2008) Assessment of regional lung recruitment and derecruitment during a peep trial based on electrical impedance tomography. Intensive Care Med 34:543–550PubMedCrossRef Meier T, Luepschen H, Karsten J, Leibecke T, Großherr M, Gehring H, Leonhardt S (2008) Assessment of regional lung recruitment and derecruitment during a peep trial based on electrical impedance tomography. Intensive Care Med 34:543–550PubMedCrossRef
25.
go back to reference Lindgren S, Odenstedt H, Olegård C, Söndergaard S, Lundin S, Stenqvist O (2007) Regional lung derecruitment after endotracheal suction during volume- or pressure-controlled ventilation: a study using electric impedance tomography. Intensive Care Med 33:172–180PubMedCrossRef Lindgren S, Odenstedt H, Olegård C, Söndergaard S, Lundin S, Stenqvist O (2007) Regional lung derecruitment after endotracheal suction during volume- or pressure-controlled ventilation: a study using electric impedance tomography. Intensive Care Med 33:172–180PubMedCrossRef
26.
go back to reference Erlandsson K, Odenstedt H, Lundin S, Stenqvist O (2006) Positive end-expiratory pressure optimization using electric impedance tomography in morbidly obese patients during laparoscopic gastric bypass surgery. Acta Anaesthesiol Scand 50:833–839PubMedCrossRef Erlandsson K, Odenstedt H, Lundin S, Stenqvist O (2006) Positive end-expiratory pressure optimization using electric impedance tomography in morbidly obese patients during laparoscopic gastric bypass surgery. Acta Anaesthesiol Scand 50:833–839PubMedCrossRef
27.
go back to reference Hinz J, Gehoff A, Moerer O, Frerichs I, Hahn G, Hellige G, Quintel M (2007) Regional filling characteristics of the lungs in mechanically ventilated patients with acute lung injury. Eur J Anaesthesiol 24:414–424PubMedCrossRef Hinz J, Gehoff A, Moerer O, Frerichs I, Hahn G, Hellige G, Quintel M (2007) Regional filling characteristics of the lungs in mechanically ventilated patients with acute lung injury. Eur J Anaesthesiol 24:414–424PubMedCrossRef
Metadata
Title
Bedside estimation of recruitable alveolar collapse and hyperdistension by electrical impedance tomography
Authors
Eduardo L. V. Costa
João Batista Borges
Alexandre Melo
Fernando Suarez-Sipmann
Carlos Toufen Jr
Stephan H. Bohm
Marcelo B. P. Amato
Publication date
01-06-2009
Publisher
Springer-Verlag
Published in
Intensive Care Medicine / Issue 6/2009
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-009-1447-y

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