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Chinese Medicine
Published in: Chinese Medicine 1/2022

Open Access 01-12-2022 | Acute Promyelocytic Leukemia | Review

Mineral medicine: from traditional drugs to multifunctional delivery systems

Authors: Xiaoqing Zhong, Zhenning Di, Yuanxin Xu, Qifan Liang, Kuanhan Feng, Yuting Zhang, Liuqing Di, Ruoning Wang

Published in: Chinese Medicine | Issue 1/2022

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Abstract

Mineral drugs are an important constituent of traditional Chinese medicine (TCM). Taking minerals that contain heavy metals as drugs is a very national characteristic part of TCM. However, the safety and scientific nature of mineral drugs are controversial owing to their heavy metals and strong toxicity. In 2000, the Food and Drug Administration (FDA) authorized arsenic trioxide (ATO) as first-line therapy for acute promyelocytic leukemia. This makes the development and utilization of mineral drugs become a research hotspot. The development of nanomedicine has found a great prospect of mineral drugs in nano-delivery carriers. And that will hold promise to address the numerous biological barriers facing mineral drug formulations. However, the studies on mineral drugs in the delivery system are few at present. There is also a lack of a detailed description of mineral drug delivery systems. In this review, the advanced strategies of mineral drug delivery systems in tumor therapy are summarized. In addition, the therapeutic advantages and research progress of novel mineral drug delivery systems are also discussed. Here, we hope that this will provide a useful reference for the design and application of new mineral drug delivery systems.

Graphical Abstract

Literature
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
Hildebrand S, Löwa N, Paysen H, Fratila RM, Reverte-Salisa L, Trakoolwilaiwan T, Niu Z, Kasparis G, Preuss SF, Kosch O, de la Fuente MJ, Thanh NTK, Wiekhorst F, Pfeifer A. Quantification of lipoprotein uptake in vivo using magnetic particle imaging and spectroscopy. ACS Nano. 2021;15(1):434–46. https://​doi.​org/​10.​1021/​acsnano.​0c03229 (Epub 2020 Dec 11).CrossRefPubMed
13.
14.
15.
16.
17.
18.
19.
20.
Lü P, Li X, Chen JW. Study on the speciation of calcium in Baihu decoction. Guang Pu Xue Yu Guang Pu Fen Xi. 2010;30(10):2824–6 (Chinese).PubMed
21.
22.
23.
24.
25.
26.
27.
Liu G, Liu F, Xiao L, Kuang Q, He X, Wang Y, Yu Y. Treatment of hyperlipidemic acute pancreatitis with modified Dachengqi decoction combining with conventional therapy based on “six-hollow-organs to be unblocked” theory. Ann Palliat Med. 2020;9(4):2045–53. https://​doi.​org/​10.​21037/​apm-20-1106 (Epub 2020 Jul 20).CrossRefPubMed
28.
29.
30.
31.
32.
33.
34.
35.
36.
37.
38.
39.
40.
41.
42.
43.
44.
45.
46.
47.
48.
49.
50.
51.
52.
53.
54.
55.
56.
57.
58.
59.
60.
61.
62.
63.
64.
65.
66.
67.
68.
69.
70.
71.
72.
73.
74.
75.
76.
77.
78.
79.
80.
Lee J, Kim H, Kim S, Lee H, Kim J, Kim N, et al. A multifunctional mesoporous nanocontainer with an iron oxide core and a cyclodextrin gatekeeper for an efficient theranostic platform. J Mater Chem. 2012;22(28):14061–7.CrossRef
81.
82.
83.
84.
85.
86.
87.
88.
89.
90.
91.
92.
93.
94.
95.
96.
97.
98.
99.
100.
Ma X, Jin T, Han C, Shi N, Liang G, Wen Y, Yang J, Fu X, Lan T, Jiang K, Nunes QM, Chvanov M, Criddle DN, Philips AR, Deng L, Liu T, Windsor JA, Sutton R, Du D, Huang W, Xia Q. Aqueous extraction from dachengqi formula granules reduces the severity of mouse acute pancreatitis via inhibition of pancreatic pro-inflammatory signalling pathways. J Ethnopharmacol. 2020;257:112861. https://​doi.​org/​10.​1016/​j.​jep.​2020.​112861 (Epub 2020 Apr 18).CrossRefPubMed
101.
102.
103.
Lee O, Ivancic D, Allu S, Shidfar A, Kenney K, Helenowski I, Sullivan ME, Muzzio M, Scholtens D, Chatterton RT Jr, Bethke KP, Hansen NM, Khan SA. Local transdermal therapy to the breast for breast cancer prevention and DCIS therapy: preclinical and clinical evaluation. Cancer Chemother Pharmacol. 2015;76(6):1235–46. https://​doi.​org/​10.​1007/​s00280-015-2848-y.CrossRefPubMed
104.
105.
106.
107.
108.
109.
110.
111.
112.
113.
Chai Y, Yin Z, Fan Q, Zhang Z, Ye K, Xu Y, Xiao W, Chai X, Zhu T, Nie H. Protective effects of angong niuhuang pill on early atherosclerosis in ApoE−/− mice by reducing the inflammatory response. Evid Based Complement Alternat Med. 2019;20(2019):9747212. https://​doi.​org/​10.​1155/​2019/​9747212.CrossRef
114.
115.
116.
117.
118.
119.
120.
121.
122.
123.
124.
125.
Zhang Y, Shen L, Wang P, Xi W, Yu Z, Huang X, Wang X, Shou D. Treatment with vancomycin loaded calcium sulphate and autogenous bone in an improved rabbit model of bone infection. J Vis Exp. 2019;(145). https://​doi.​org/​10.​3791/​57294
126.
127.
128.
129.
130.
131.
Rajiv S, Jerobin J, Saranya V, Nainawat M, Sharma A, Makwana P, Gayathri C, Bharath L, Singh M, Kumar M, Mukherjee A, Chandrasekaran N. Comparative cytotoxicity and genotoxicity of cobalt (II, III) oxide, iron (III) oxide, silicon dioxide, and aluminum oxide nanoparticles on human lymphocytes in vitro. Hum Exp Toxicol. 2016;35(2):170–83. https://​doi.​org/​10.​1177/​0960327115579208​ (Epub 2015 Mar 31).CrossRefPubMed
132.
133.
Han Z, Song L, Qi K, Ding Y, Wei M, Jia Y. Deciphering the key pharmacological pathways and targets of yisui qinghuang powder that acts on myelodysplastic syndromes using a network pharmacology-based strategy. Evid Based Complement Alternat Med. 2020;8(2020):8877295. https://​doi.​org/​10.​1155/​2020/​8877295.CrossRef
134.
135.
136.
Song P, Chen P, Wang D, Wu Z, Gao Q, Wang A, Zhu R, Wang Y, Wang X, Zhao L, Duan Z, Zhu S, Cui P, Li Y, Li H. Realgar transforming solution displays anticancer potential against human hepatocellular carcinoma HepG2 cells by inducing ROS. Int J Oncol. 2017;50(2):660–70. https://​doi.​org/​10.​3892/​ijo.​2016.​3831 (Epub 2016 Dec 30).CrossRefPubMed
137.
138.
139.
140.
141.
Zhao Y, Yuan B, Onda K, Sugiyama K, Tanaka S, Takagi N, Hirano T. Anticancer efficacies of arsenic disulfide through apoptosis induction, cell cycle arrest, and pro-survival signal inhibition in human breast cancer cells. Am J Cancer Res. 2018;8(3):366–86.PubMedPubMedCentral
142.
Yousefi B, Semnani V, Mokhtari T, Zarbakhsh S, Amjad MHT, Barati M, Doustmohammadi H. Co-administration of aluminum sulfate and propolis regulates matrix metalloproteinases-2/9 expression and improves the uterine leiomyoma in adult rat model. Biol Trace Elem Res. 2021;199(3):1002–12. https://​doi.​org/​10.​1007/​s12011-020-02200-0 (Epub 2020 Jun 27).CrossRefPubMed
143.
Pan W, Cai S, Latour JM, Zhong M, Lv M, Li J, Zhang X, Zhang Y. External use of Mirabilite combined with Lactulose improves postoperative gastrointestinal mobility among older patients undergoing abdominal surgery. J Adv Nurs. 2021;77(2):755–62. https://​doi.​org/​10.​1111/​jan.​14640 (Epub 2020 Nov 24).CrossRefPubMed
144.
Metadata
Title
Mineral medicine: from traditional drugs to multifunctional delivery systems
Authors
Xiaoqing Zhong
Zhenning Di
Yuanxin Xu
Qifan Liang
Kuanhan Feng
Yuting Zhang
Liuqing Di
Ruoning Wang
Publication date
01-12-2022
Publisher
BioMed Central
Published in
Chinese Medicine / Issue 1/2022
Electronic ISSN: 1749-8546
DOI
https://doi.org/10.1186/s13020-022-00577-9

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