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Open Access 01-12-2022 | Acute Pancreatitis | Review

New challenges for microRNAs in acute pancreatitis: progress and treatment

Authors: Wence Zhou, Shi Dong, Zhou Chen, Xin Li, Wenkai Jiang

Published in: Journal of Translational Medicine | Issue 1/2022

Abstract

Acute pancreatitis (AP) is a common clinical abdominal emergency, with a high and increasing incidence each year. Severe AP can easily cause systemic inflammatory response syndrome, multiple organ dysfunction and other complications, leading to higher hospitalization rates and mortality. Currently, there is no specific treatment for AP. Thus, we still need to understand the exact AP pathogenesis to effectively cure AP. With the rise of transcriptomics, RNA molecules, such as microRNAs (miRNAs) transcribed from nonprotein-coding regions of biological genomes, have been found to be of great significance in the regulation of gene expression and to be involved in the occurrence and development of many diseases. Increasing evidence has shown that miRNAs, as regulatory RNAs, can regulate pancreatic acinar necrosis and apoptosis and local and systemic inflammation and play an important role in the development and thus potentially the diagnosis and treatment of AP. Therefore, here, the current research on the relationship between miRNAs and AP is reviewed.

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Title: New challenges for microRNAs in acute pancreatitis: progress and treatment
Authors: Wence Zhou
Shi Dong
Zhou Chen
Xin Li
Wenkai Jiang
Publication date: 01-12-2022
Publisher: BioMed Central
Keyword: Acute Pancreatitis
Published in: Journal of Translational Medicine / Issue 1/2022
Electronic ISSN: 1479-5876
DOI: https://doi.org/10.1186/s12967-022-03338-2

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