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Indian Journal of Gastroenterology
Published in: Indian Journal of Gastroenterology 2/2024

26-04-2024 | Acute Liver Failure | Research letter

Difficult transplant decisions in acute liver failure —Benefit versus futility, where to draw a line

Authors: Shweta A. Singh, Shekhar Jadaun, Avijit Gain, Sanjiv Saigal, Subhash Gupta

Published in: Indian Journal of Gastroenterology | Issue 2/2024

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Excerpt

Acute liver failure (ALF) is a condition characterized by severe liver injury with jaundice, altered coagulation and encephalopathy in patients without pre-existing liver disease. Patients with ALF often have the potential for spontaneous recovery with supportive management [1]. However, sometimes they deteriorate rapidly, either neurologically with intra-cranial hypertension or with fulminant sepsis, hence missing the optimal window for liver transplant (LT). …
Literature
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Bernuau J, Rueff B, Benhamou JP. Fulminant and subfulminant liver failure: definitions and causes. Semin Liver Dis. 1986;6:97–106.CrossRefPubMed
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Germani G, Theocharidou E, Adam R, et al. Liver transplantation for acute liver failure in Europe: outcomes over 20 years from the ELTR database. J Hepatol. 2012;57:288–96.CrossRefPubMed
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McPhail MJW, Wendon JA, Bernal W. Meta-analysis of performance of King’s College Hospital Criteria in prediction of outcome in non-paracetamol-induced acute liver failure. J Hepatol. 2010;53:492–9.CrossRefPubMed
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Bernuau J, Goudeau A, Poynard T, et al. Multivariate analysis of prognostic factors in fulminant hepatitis B. Hepatology. 1986;6:648–51.CrossRefPubMed
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Kumar R, Shalimar, Sharma H, et al. Prospective derivation and validation of early dynamic model for predicting outcome in patients with acute liver failure. Gut. 2012;61:1068–75.CrossRefPubMed
Metadata
Title
Difficult transplant decisions in acute liver failure —Benefit versus futility, where to draw a line
Authors
Shweta A. Singh
Shekhar Jadaun
Avijit Gain
Sanjiv Saigal
Subhash Gupta
Publication date
26-04-2024
Publisher
Springer India
Published in
Indian Journal of Gastroenterology / Issue 2/2024
Print ISSN: 0254-8860
Electronic ISSN: 0975-0711
DOI
https://doi.org/10.1007/s12664-024-01579-1

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Keynote webinar | Spotlight on medication adherence

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