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BMC Cardiovascular Disorders
Published in: BMC Cardiovascular Disorders 1/2024

Open Access 01-12-2024 | Acute Kidney Injury | Research

Preoperative serum selenium predicts acute kidney injury after adult cardiac surgery

Authors: Guowei Fu, Shuying Bai

Published in: BMC Cardiovascular Disorders | Issue 1/2024

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Abstract

Background

The relationship between serum selenium (Se) and acute kidney injury after adult cardiac surgery (CSA-AKI) remains controversial. This study aimed to investigate the association of preoperative Se level with incident CSA-AKI.

Method and Results

A retrospective cohort study was conducted on patients who underwent cardiac surgery. The primary outcome was incident CSA-AKI. Multivariable logistic regression models and natural cubic splines were used to estimate the association of Se levels and primary outcome. A total of 453 patient with a mean age of 62.97 years were included. Among all patients, 159 (35.1%) incident cases of CSA-AKI were identified. The level of preoperative Se concentration in patients with CSA-AKI was significant lower than that in patients without CSA-AKI. The higher preoperative Se level was significantly associated with decreased risk of CSA-AKI (adjusted OR 0.91, 95% CI: 0.87–0.99). Dose-response relationship curve revealed a nearly L-shape correlation between serum Se selenium levels and incident CSA-AKI.

Conclusion

Our study suggested that a higher level of serum Se was significantly associated with lower risk of CSA-AKI. Further prospective studies are needed to clarify the causal relationship between serum Se level and incident CSA-AKI.
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Metadata
Title
Preoperative serum selenium predicts acute kidney injury after adult cardiac surgery
Authors
Guowei Fu
Shuying Bai
Publication date
01-12-2024
Publisher
BioMed Central
Published in
BMC Cardiovascular Disorders / Issue 1/2024
Electronic ISSN: 1471-2261
DOI
https://doi.org/10.1186/s12872-024-03825-y

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