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Pediatric Nephrology

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21-11-2023 | Acute Kidney Injury | Original Article

A reappraisal of risk factors for hypertension after pediatric acute kidney injury

Authors: Mital Patel, Christoph Hornik, Clarissa Diamantidis, David T. Selewski, Rasheed Gbadegesin

Published in: Pediatric Nephrology | Issue 5/2024

Abstract

Background

Acute kidney injury (AKI) is common in hospitalized children and increases the risk of chronic kidney disease (CKD) and hypertension, but little is known about the patient level risk factors for pediatric hypertension after AKI. The aims of this study are to evaluate the prevalence and risk factors for new onset hypertension in hospitalized children with AKI and to better understand the role of acute kidney disease (AKD) in the development of hypertension.

Methods

This study was an observational cohort of all children ≤ 18 years old admitted to a single tertiary care children’s hospital from 2015 to 2019 with a diagnosis of AKI. Hypertension was defined as blood pressure > 95th percentile for sex, age, height, diagnosis of hypertension on the problem list, or prescription of antihypertensive medication for > 90 days after AKI.

Results

A total of 410 children were included in the cohort. Of these, 78 (19%) developed hypertension > 90 days after AKI. A multivariable logistic regression model identified AKD, need for kidney replacement therapy, congenital heart disease, and non-kidney solid organ transplantation as risk factors for hypertension after AKI.

Conclusions

Incident hypertension after 3 months is common among hospitalized children with AKI, and AKD, need for dialysis, congenital heart disease, and non-kidney solid organ transplant are significant risk factors for hypertension after AKI. Monitoring for hypertension development in these high-risk children is critical to mitigate long-term adverse kidney and cardiovascular outcomes.

Graphical abstract

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Title: A reappraisal of risk factors for hypertension after pediatric acute kidney injury
Authors: Mital Patel
Christoph Hornik
Clarissa Diamantidis
David T. Selewski
Rasheed Gbadegesin
Publication date: 21-11-2023
Publisher: Springer Berlin Heidelberg
Keywords: Acute Kidney Injury
Acute Kidney Injury
Hypertension
Hypertension
Chronic Kidney Disease
Published in: Pediatric Nephrology / Issue 5/2024
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-023-06222-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

A reappraisal of risk factors for hypertension after pediatric acute kidney injury

Abstract

Background

Methods

Results

Conclusions

Graphical abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Graphical abstract

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