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02-12-2023 | Chronic Kidney Disease | Original Article

Characteristics and predictors of chronic kidney disease in children with myelomeningocele: a nationwide cohort study

Authors: Çağla Serpil Doğan, Sevgin Taner, Betül Durucu Tiryaki, Demet Alaygut, Neşe Özkayın, Aslıhan Kara, Aylin Gençler, Ayşe Seda Pınarbaşı, Hülya Nalçacıoğlu, Selçuk Yüksel, Okan Akacı, Esra Karabağ Yılmaz, Sevgi Yavuz, Kenan Doğan, Rumeysa Yasemin Çiçek Gülşan, Gülşah Kaya Aksoy, Neslihan Çiçek, Bağdagül Aksu, Nuran Küçük, Fatma Şemsa Altugan, Şenay Zırhlı Selçuk, Funda Baştuğ, Gökçen Erfidan, Bahriye Atmış, Arife Uslu Gökçeoğlu, Esra Nagehan Akyol Önder, Ahmet Mithat Elmacı, Nurcan Cengiz, Kaan Gülleroğlu, Ebru Bekiroğlu Yılmaz, Aslı Çelebi Tayfur, Gülsün Gülay Yılmaz, Sİbel Yel, Cemile Pehlivanoğlu, Cihangir Akgün, Mehtap Akbalık Kara, Beltinge Demircioğlu Kılıç, Özgür Özdemir Şimşek, Melike Yucal, Buket Esen Ağar, Metin Kaya Gürgöze, İsmail Yağmur, Ömer Madsar, Demet Tekcan Karalı, İlknur Girişgen, Ece Demirci Bodur, Elif Çomak, İbrahim Gökçe, Mehtap Kaya, Yılmaz Tabel, Neslihan Günay, Rüveyda Gülmez, Salim Çalışkan

Published in: Pediatric Nephrology | Issue 5/2024

Abstract

Background

Myelomeningocele (MMC) is highly prevalent in developing countries, and MMC-related neurogenic bladder is an important cause of childhood chronic kidney disease (CKD). This nationwide study aimed to evaluate demographic and clinical features of pediatric patients with MMC in Turkey and risk factors associated with CKD stage 5.

Methods

Data from children aged 0–19 years old, living with MMC in 2022, were retrospectively collected from 27 pediatric nephrology centers. Patients > 1 year of age without pre-existing kidney abnormalities were divided into five groups according to eGFR; CKD stages 1–5. Patients on dialysis, kidney transplant recipients, and those with eGFR < 15 ml/min/1.73 m² but not on kidney replacement therapy at time of study constituted the CKD stage 5 group.

Results

A total of 911 (57.8% female) patients were enrolled, most of whom were expectantly managed. Stages 1–4 CKD were found in 34.3%, 4.2%, 4.1%, and 2.4%, respectively. CKD stage 5 was observed in 5.3% of patients at median 13 years old (range 2–18 years). Current age, age at first abnormal DMSA scan, moderate-to-severe trabeculated bladder on US and/or VCUG, and VUR history were independent risk factors for development of CKD stage 5 (OR 0.752; 95%; CI 0.658–0.859; p < 0.001; OR 1.187; 95% CI 1.031–1.367; p = 0.017; OR 10.031; 95% CI 2.210–45.544; p = 0.003; OR 2.722; 95% CI 1.215–6.102; p = 0.015, respectively). Only eight CKD stage 5 patients underwent surgery related to a hostile bladder between 1 and 15 years old.

Conclusion

MMC-related CKD is common in childhood in Turkey. A proactive approach to neurogenic bladder management and early protective surgery in selected cases where conservative treatment has failed should be implemented to prevent progressive kidney failure in the pediatric MMC population in our country.

Graphical abstract

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Title: Characteristics and predictors of chronic kidney disease in children with myelomeningocele: a nationwide cohort study
Authors: Çağla Serpil Doğan
Sevgin Taner
Betül Durucu Tiryaki
Demet Alaygut
Neşe Özkayın
Aslıhan Kara
Aylin Gençler
Ayşe Seda Pınarbaşı
Hülya Nalçacıoğlu
Selçuk Yüksel
Okan Akacı
Esra Karabağ Yılmaz
Sevgi Yavuz
Kenan Doğan
Rumeysa Yasemin Çiçek Gülşan
Gülşah Kaya Aksoy
Neslihan Çiçek
Bağdagül Aksu
Nuran Küçük
Fatma Şemsa Altugan
Şenay Zırhlı Selçuk
Funda Baştuğ
Gökçen Erfidan
Bahriye Atmış
Arife Uslu Gökçeoğlu
Esra Nagehan Akyol Önder
Ahmet Mithat Elmacı
Nurcan Cengiz
Kaan Gülleroğlu
Ebru Bekiroğlu Yılmaz
Aslı Çelebi Tayfur
Gülsün Gülay Yılmaz
Sİbel Yel
Cemile Pehlivanoğlu
Cihangir Akgün
Mehtap Akbalık Kara
Beltinge Demircioğlu Kılıç
Özgür Özdemir Şimşek
Melike Yucal
Buket Esen Ağar
Metin Kaya Gürgöze
İsmail Yağmur
Ömer Madsar
Demet Tekcan Karalı
İlknur Girişgen
Ece Demirci Bodur
Elif Çomak
İbrahim Gökçe
Mehtap Kaya
Yılmaz Tabel
Neslihan Günay
Rüveyda Gülmez
Salim Çalışkan
Publication date: 02-12-2023
Publisher: Springer Berlin Heidelberg
Keywords: Chronic Kidney Disease
Neurogenic Bladder
Vesicorenal Reflux
Spina Bifida
Spina Bifida
Published in: Pediatric Nephrology / Issue 5/2024
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-023-06212-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Characteristics and predictors of chronic kidney disease in children with myelomeningocele: a nationwide cohort study

Abstract

Background

Methods

Results

Conclusion

Graphical abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

Graphical abstract

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