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Diabetes Therapy
Published in: Diabetes Therapy 1/2019

Open Access 01-02-2019 | Review

A Review of Practical Issues on the Use of Glucagon-Like Peptide-1 Receptor Agonists for the Management of Type 2 Diabetes

Authors: Irene Romera, Ana Cebrián-Cuenca, Fernando Álvarez-Guisasola, Fernando Gomez-Peralta, Jesús Reviriego

Published in: Diabetes Therapy | Issue 1/2019

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Abstract

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are well established as effective treatments for patients with type 2 diabetes. GLP-1 RAs augment insulin secretion and suppress glucagon release via the stimulation of GLP-1 receptors. Although all GLP-1 RAs share the same underlying mechanism of action, they differ in terms of formulations, administration, injection devices and dosages. With six GLP-1 RAs currently available in Europe (namely, immediate-release exenatide, lixisenatide, liraglutide; prolonged-release exenatide, dulaglutide and semaglutide), each with its own characteristics and administration requirements, physicians caring for patients in their routine practice face the challenge of being cognizant of all this information so they are able to select the agent that is most suitable for their patient and use it in an efficient and optimal way. The objective of this review is to bring together practical information on the use of these GLP-1 RAs that reflects their approved use.
Funding: Eli Lilly and Company.
Plain Language Summary: Plain language summary available for this article.
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Metadata
Title
A Review of Practical Issues on the Use of Glucagon-Like Peptide-1 Receptor Agonists for the Management of Type 2 Diabetes
Authors
Irene Romera
Ana Cebrián-Cuenca
Fernando Álvarez-Guisasola
Fernando Gomez-Peralta
Jesús Reviriego
Publication date
01-02-2019
Publisher
Springer Healthcare
Published in
Diabetes Therapy / Issue 1/2019
Print ISSN: 1869-6953
Electronic ISSN: 1869-6961
DOI
https://doi.org/10.1007/s13300-018-0535-9

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