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Breast Cancer Research
Published in: Breast Cancer Research 6/2014

Open Access 01-12-2014 | Viewpoint

A novel mechanism of regulation of the anti-metastatic miR-31 by EMSY in breast cancer

Authors: Laoighse Mulrane, William M Gallagher, Darran P O’Connor

Published in: Breast Cancer Research | Issue 6/2014

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Abstract

miR-31 is well known as an anti-metastatic microRNA (miRNA) in the context of breast cancer. However, to date the mechanism of regulation of this miRNA has yet to be elucidated. The recent publication by Viré et al. in Molecular Cell [1] demonstrates for the first time that one mechanism of regulation of miR-31 is through the putative oncogene EMSY, whose amplification in breast cancer patients correlates with reduced expression of the miRNA. This regulation is dependent on the DNA-binding transcription factor ETS-1 which recruits EMSY and the histone demethylase KDM5B to the miR-31 promoter, thus repressing its transcription.
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Literature
1.
Valastyan S, Reinhardt F, Benaich N, Calogrias D, Szasz AM, Wang ZC, Brock JE, Richardson AL, Weinberg RA: A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Cell. 2009, 137: 1032-1046. 10.1016/j.cell.2009.03.047.CrossRefPubMedPubMedCentral
2.
Valastyan S, Benaich N, Chang A, Reinhardt F, Weinberg RA: Concomitant suppression of three target genes can explain the impact of a microRNA on metastasis. Genes Dev. 2009, 23: 2592-2597. 10.1101/gad.1832709.CrossRefPubMedPubMedCentral
3.
Sossey-Alaoui K, Downs-Kelly E, Das M, Izem L, Tubbs R, Plow EF: WAVE3, an actin remodeling protein, is regulated by the metastasis suppressor microRNA, miR-31, during the invasion-metastasis cascade. Int J Cancer. 2011, 129: 1331-1343. 10.1002/ijc.25793.CrossRefPubMedPubMedCentral
4.
Valastyan S, Chang A, Benaich N, Reinhardt F, Weinberg RA: Concurrent suppression of integrin alpha5, radixin, and RhoA phenocopies the effects of miR-31 on metastasis. Cancer Res. 2010, 70: 5147-5154. 10.1158/0008-5472.CAN-10-0410.CrossRefPubMedPubMedCentral
5.
Valastyan S, Chang A, Benaich N, Reinhardt F, Weinberg RA: Activation of miR-31 function in already-established metastases elicits metastatic regression. Genes Dev. 2011, 25: 646-659. 10.1101/gad.2004211.CrossRefPubMedPubMedCentral
6.
Hughes-Davies L, Huntsman D, Ruas M, Fuks F, Bye J, Chin SF, Milner J, Brown LA, Hsu F, Gilks B, Nielsen T, Schulzer M, Chia S, Ragaz J, Cahn A, Linger L, Ozdag H, Cattaneo E, Jordanova ES, Schuuring E, Yu DS, Venkitaraman A, Ponder B, Doherty A, Aparicio S, Bentley D, Theillet C, Ponting CP, Caldas C, Kouzarides T: EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer. Cell. 2003, 115: 523-535. 10.1016/S0092-8674(03)00930-9.CrossRefPubMed
7.
Vire E, Curtis C, Davalos V, Git A, Robson S, Villanueva A, Vidal A, Barbieri I, Aparicio S, Esteller M, Caldas C, Kouzarides T: The Breast Cancer Oncogene EMSY Represses Transcription of Antimetastatic microRNA miR-31. Mol Cell. 2014, 53: 806-818. 10.1016/j.molcel.2014.01.029.CrossRefPubMedPubMedCentral
8.
Curtis C, Shah SP, Chin SF, Turashvili G, Rueda OM, Dunning MJ, Speed D, Lynch AG, Samarajiwa S, Yuan Y, Gräf S, Ha G, Haffari G, Bashashati A, Russell R, McKinney S, METABRIC Group, Langerød A, Green A, Provenzano E, Wishart G, Pinder S, Watson P, Markowetz F, Murphy L, Ellis I, Purushotham A, Børresen-Dale AL, Brenton JD, Tavaré S, Caldas C, Aparicio S: The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups. Nature. 2012, 486: 346-352.PubMedPubMedCentral
9.
Dvinge H, Git A, Graf S, Salmon-Divon M, Curtis C, Sottoriva A, Zhao Y, Hirst M, Armisen J, Miska EA, Chin SF, Provenzano E, Turashvili G, Green A, Ellis I, Aparicio S, Caldas C: The shaping and functional consequences of the microRNA landscape in breast cancer. Nature. 2013, 497: 378-382. 10.1038/nature12108.CrossRefPubMed
10.
Melo SA, Esteller M: Dysregulation of microRNAs in cancer: playing with fire. FEBS Lett. 2011, 585: 2087-2099. 10.1016/j.febslet.2010.08.009.CrossRefPubMed
11.
12.
Mulrane L, McGee SF, Gallagher WM, O'Connor DP: miRNA dysregulation in breast cancer. Cancer Res. 2013, 73: 6554-6562. 10.1158/0008-5472.CAN-13-1841.CrossRefPubMed
13.
Augoff K, McCue B, Plow EF, Sossey-Alaoui K: miR-31 and its host gene lncRNA LOC554202 are regulated by promoter hypermethylation in triple-negative breast cancer. Mol Cancer. 2012, 11: 5-10.1186/1476-4598-11-5.CrossRefPubMedPubMedCentral
14.
Vrba L, Munoz-Rodriguez JL, Stampfer MR, Futscher BW: miRNA gene promoters are frequent targets of aberrant DNA methylation in human breast cancer. PLoS One. 2013, 8: e54398-10.1371/journal.pone.0054398.CrossRefPubMedPubMedCentral
15.
Bracken CP, Gregory PA, Kolesnikoff N, Bert AG, Wang J, Shannon MF, Goodall GJ: A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. Cancer Res. 2008, 68: 7846-7854. 10.1158/0008-5472.CAN-08-1942.CrossRefPubMed
Metadata
Title
A novel mechanism of regulation of the anti-metastatic miR-31 by EMSY in breast cancer
Authors
Laoighse Mulrane
William M Gallagher
Darran P O’Connor
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 6/2014
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/s13058-014-0467-x

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