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Breast Cancer Research
Published in: Breast Cancer Research 6/2014

Open Access 01-12-2014 | Viewpoint

An unexpected alliance between stress responses to drive oncogenesis

Authors: Melissa M Keenan, Chien-Kuang Cornelia Ding, Jen-Tsan Chi

Published in: Breast Cancer Research | Issue 6/2014

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Abstract

XBP1 is a well-characterized regulator of the unfolding protein response that is activated in response to unfolded or misfolded proteins or nutrient deprivation. The conventional wisdom is that XBP1 is activated to coordinate the unfolded protein response and promote cellular survival under stresses. A recent study provides intriguing evidence that, in triple-negative breast cancer, XBP1 plays a major role in promoting oncogenesis and cancer stem cell properties. Unexpectedly, XBP1 accomplishes this by recruiting hypoxia-inducible factor 1α and activating oncogenic transcriptional programs. This study reveals a surprising hierarchy and alliance between two stress regulators with distinct transcriptional outputs to promote an aggressive oncogenic state.
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Metadata
Title
An unexpected alliance between stress responses to drive oncogenesis
Authors
Melissa M Keenan
Chien-Kuang Cornelia Ding
Jen-Tsan Chi
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 6/2014
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/s13058-014-0471-1

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