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Current Osteoporosis Reports
Published in: Current Osteoporosis Reports 6/2015

01-12-2015 | Bone and Joint Pain (PW Mantyh and TJ Schnitzer, Section Editors)

A Mechanism-Based Approach to the Management of Osteoarthritis Pain

Authors: Ezra Cohen, Yvonne C. Lee

Published in: Current Osteoporosis Reports | Issue 6/2015

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Abstract

Pain from osteoarthritis (OA) affects millions of people worldwide, yet treatments are limited to acetaminophen, NSAIDs, physical therapy, and ultimately, surgery when there is significant disability. In recent years, our understanding of pain pathways in OA has developed considerably. Though joint damage and inflammation play a significant role in pain generation, it is now understood that both central and peripheral nervous system mechanisms exacerbate symptoms. Evolving management strategies for OA address central factors (e.g., sleep difficulties, catastrophizing, and depression) with treatments such as cognitive behavioral therapy and exercise. In addition, emerging data suggest that antibodies against peripheral signaling neuropeptides, such as nerve growth factor-1 (NGF-1), may significantly alleviate pain. However, concerns regarding potential adverse effects, such as rapidly progressive OA, still remain. A nuanced understanding is essential if we are to make headway in developing more effective treatments for OA.
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Metadata
Title
A Mechanism-Based Approach to the Management of Osteoarthritis Pain
Authors
Ezra Cohen
Yvonne C. Lee
Publication date
01-12-2015
Publisher
Springer US
Published in
Current Osteoporosis Reports / Issue 6/2015
Print ISSN: 1544-1873
Electronic ISSN: 1544-2241
DOI
https://doi.org/10.1007/s11914-015-0291-y

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