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Medical Oncology
Published in: Medical Oncology 2/2012

01-06-2012 | Case Report

A case report of a 33-year chronic phase survivor of chronic myeloid leukemia

Authors: Ou Ji, Qun Shen, Ya-Cheng Zhang, Jian-Min Ji, Guang-Rong Zhu, Lin Lin, Xiang-Tu Kong, Wen Xia, Peng-Jun Jiang

Published in: Medical Oncology | Issue 2/2012

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Abstract

Here, we report a Philadelphia chromosome-positive chronic myeloid leukemia case with the longest chronic phase and overall survival to our knowledge ever reported in the medical literature. During the 33-year chronic phase, he was asymptomatic without any treatment and had normal blood cell values. BCR–ABL silencing might be referred to the uncommon long-term survivor.
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Busuttil DP. Prolonged imatinib-induced myelosuppression in chronic myeloid leukaemia with an unusually long survival. Int J Lab Hematol. 2008;30:68–70.PubMed
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Rangatia J, Bonnet D. Transient or long-term silencing of BCR-ABL alone induces cell cycle and proliferation arrest, apoptosis and differentiation. Leukemia. 2006;20:68–76.PubMedCrossRef
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Bedi A, Zehnbauer BA, Collector MI, Barber JP, Zicha MS, Sharkis SJ, Jones RJ. BCR-ABL gene rearrangement and expression of primitive hematopoietic progenitors in chronic myeloid leukemia. Blood. 1993;81:2898–902.PubMed
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Metadata
Title
A case report of a 33-year chronic phase survivor of chronic myeloid leukemia
Authors
Ou Ji
Qun Shen
Ya-Cheng Zhang
Jian-Min Ji
Guang-Rong Zhu
Lin Lin
Xiang-Tu Kong
Wen Xia
Peng-Jun Jiang
Publication date
01-06-2012
Publisher
Springer US
Published in
Medical Oncology / Issue 2/2012
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-011-9874-3

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Keynote webinar | Spotlight on medication adherence

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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