Published in:
05-09-2023 | Zolpidem | Short Paper
Impact of zolpidem and lemborexant on sleep and morning symptoms when used as a single dose for polysomnography
Authors:
Hiroyuki Sawatari, Tomoko Yoshikawa, Shin-ichi Ando
Published in:
Sleep and Biological Rhythms
|
Issue 1/2024
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Abstract
This study evaluated the effect of zolpidem and lemborexant on sleep and morning symptoms in patients undergoing type-1 polysomnography for suspected sleep-disordered breathing based on questionnaires and polysomnography results. We enrolled 127 patients (lemborexant: N = 57, zolpidem: N = 25, without hypnotics: N = 45). Rapid eye movement sleep in patients on lemborexant was higher than that in patients without hypnotics (P = 0.02). Frequency of unsteadiness in the morning was higher in patients on zolpidem than that in patients without hypnotics (P = 0.04), which remained after adjustment for potential confounders (P = 0.03). Low-dose lemborexant might be suitable when administered as a single dose during polysomnography.