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Published in: Sleep and Biological Rhythms 1/2024

22-09-2023 | Original Article

Assessment of cognitive function and sleep–wake rhythms in community-dwelling older adults

Authors: Masato Okuda, Akiko Noda, Kunihiro Iwamoto, Nozomi Hishikawa, Seiko Miyata, Fumihiko Yasuma, Toshiaki Taoka, Norio Ozaki, Julie A. Suhr, Soichiro Miyazaki

Published in: Sleep and Biological Rhythms | Issue 1/2024

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Abstract

Disruption of the circadian rhythm and sleep–wake cycles is a consequence of aging and is associated with the cognitive decline and many neurodegenerative conditions. We investigated the bedtime, wake-up time, sleep timing (midpoint between bedtime and wake-up time), and sleep timing standard deviation (SD) using the actigraphy among 80 consecutive volunteers aged ≥ 60 years. Global cognitive function and executive function of detailed cognitive domains were evaluated using the mini-mental state examination (MMSE) and Wisconsin card sorting test (WCST) and subjective daytime sleepiness was assessed using the Epworth Sleepiness Scale (ESS). The category achievement (CA), total errors (TE), perseverative errors of Nelson (PEN), non-perseverative errors (NPE), and difficulties in maintaining set (DMS) on the WCST were significantly correlated with sleep timing SD (CA: r = − 0.276, p = 0.013, TE: r = 0.311, p = 0.005, PEN: r = 0.241, p = 0.032, NPE: r = 0.250, p = 0.025, DMS: r = 0.235, p = 0.036), but not with the MMSE score. Multiple regression analyses with the stepwise forward selection method including age, ESS score, bedtime, sleep timing, and sleep timing SD, revealed that the ESS score, and sleep timing SD were significant factors related to CA on the WCST (ESS score: β = − 0.322, p = 0.004; sleep timing SD: β = − 0.250, p = 0.022). Assessment of sleep–wake rhythms, daytime sleepiness, and cognitive function using the MMSE and WCST is valuable for the prediction of cognitive decline in the geriatric population.
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Metadata
Title
Assessment of cognitive function and sleep–wake rhythms in community-dwelling older adults
Authors
Masato Okuda
Akiko Noda
Kunihiro Iwamoto
Nozomi Hishikawa
Seiko Miyata
Fumihiko Yasuma
Toshiaki Taoka
Norio Ozaki
Julie A. Suhr
Soichiro Miyazaki
Publication date
22-09-2023
Publisher
Springer Nature Singapore
Published in
Sleep and Biological Rhythms / Issue 1/2024
Print ISSN: 1446-9235
Electronic ISSN: 1479-8425
DOI
https://doi.org/10.1007/s41105-023-00491-z

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