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BMC Pediatrics
Published in: BMC Pediatrics 1/2019

Open Access 01-12-2019 | Zika Virus | Research article

Clinical findings in congenital infection by Zika virus: a retrospective study in a reference hospital in Central-West Brazil

Authors: Cláudia de Paula Guimarães, Myrella Silveira Macedo, Maria Alves Barbosa, Solomar Martins Marques, Paulo Sucasas Costa, Ênio Chaves de Oliveira

Published in: BMC Pediatrics | Issue 1/2019

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Background

An increased number of congenital Zika virus infections with neurological and musculoskeletal malformations have been diagnosed worldwide, however, there are still several gaps in the knowledge about this infection, its associated mechanism, timing of transmission, and description of throughout findings of signs and symptoms, which is described in this paper. The purpose of this study is to describe aspects of congenital Zika syndrome (CZS) beyond the central nervous system comprising detailed delineation of all the other clinical findings.

Methods

A retrospective research developed using electronic medical records. We analyzed the files of 69 children with an initial diagnosis of microcephaly by Zika vírus who were born in 2015, 2016 and 2017, treated during the period from 2016 to 2017.

Results

The newborns presented several neurological and musculoskeletal malformations, eye damage, hearing impairment and other malformations.

Conclusions

The present study has significant impact for health care teams following lactents with Congenital Zika Syndrome.
Literature
1.
2.
Icheky V. A review of the evidence linking Zika virus to the developmental abnormalities that Lead to microcephaly in view of recent Casees of birth defects in Africa. Journal of MPE Molecular Pathological Epidemiologçy, Vol. 2 N. S1:01, 2017.
3.
Blohm, et al., Evidence for Mother-to-Child Transmission of Zika Virus Through Breast Milk. Clinical Infections Diseases, Vol. 66 Issue 7, 19 March 2018, Pages 1120–1121.CrossRef
4.
Seferovic M, Martín CS, Tardif SD. Experimental Zika Virus Infection in the Pregnant Common Marmoset Induces Spontaneous Fetal Loss and Neurodevelopmental Abnormalities. Sci Rep. 2018 May 1;8(1):6851.CrossRef
5.
Santa Rita TH, Barra RB, Peixoto GP, Mesquita PG, Barra GB. Association between suspected Zika virus disease during pregnancy and giving birth to a newborn with congenital microcephaly: a matched case-control study. BMC Res Notes. 2017;10(1):457.CrossRef
6.
de Araujo TVB, Ximenes RAA, Miranda-Filho DB, Souza WV, Montarroyos UR, de Melo APL, et al. Association between microcephaly, Zika virus infection, and other risk factors in Brazil: final report of a case-control study. Lancet Infect Dis. 2018;18(3):328–36.CrossRef
7.
Brasil P, Pereira JP Jr, Moreira ME, Ribeiro Nogueira RM, Damasceno L, Wakimoto M, et al. Zika virus infection in pregnant women in Rio de Janeiro. N Engl J Med. 2016;375(24):2321–34.CrossRef
8.
Subissi L, Dub T, Besnard M, Mariteragi-Helle T, Nhan T, Lutringer-Magnin D, et al. Zika virus infection during pregnancy and effects on early childhood development, French Polynesia, 2013-2016. Emerg Infect Dis. 2018;24(10):1850–8.CrossRef
9.
Meaney-Delman et al. Zika Virus and Pregnancy What Obstretic Health Care Providers Need to Know. OBSTETRICS&GYNECOLOGY Vol. 0, No. 0, MONTH 2016.
10.
Ticconi C, PietropollI A, Rezza G. Zika Virus Infection in Pregnancy: what we do and do not know. Pathogens and Global Health, 2016, vol 110, NOS. 7&8.
11.
van der Linden et al. Epilepsy Profile in Infants with Congenital Zika Virus Infection. N ENGL J MED 379;9 NEJM.ORG AUGUST 30, 2018.
12.
Ribeiro, et al. Microcefalia no Piaui, Brasil: estudo descritivo durante a epidemia do virus Zika, 2015–2016. Epidemiol. Serv. Saude, Brasília. 2018;27(1):e 20163692).
13.
Caires-Júnior LC, et al. Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells. Nature communications. 2018;9:475.CrossRef
14.
Alvarado MG, Schwartz, DA. Zika virus infection in pregnancy, microcephaly, and maternal and fetal health what we think, what we know, and what we think we know. Arch Pathol Lab Med-Vol 141, January 2017.
15.
16.
17.
18.
Krow-Lucal ER, de Andrade MR, Cananéa JNA, Moore CA, Leite PL, Biggerstaff BJ, et al. Association and birth prevalence of microcephaly attributable to Zika virus infection among infants in Paraíba, Brazil, in 2015-16: a case-control study. The Lancet Child & Adolescent Health. 2018;2(3):205–13.CrossRef
Metadata
Title
Clinical findings in congenital infection by Zika virus: a retrospective study in a reference hospital in Central-West Brazil
Authors
Cláudia de Paula Guimarães
Myrella Silveira Macedo
Maria Alves Barbosa
Solomar Martins Marques
Paulo Sucasas Costa
Ênio Chaves de Oliveira
Publication date
01-12-2019
Publisher
BioMed Central
Keyword
Zika Virus
Published in
BMC Pediatrics / Issue 1/2019
Electronic ISSN: 1471-2431
DOI
https://doi.org/10.1186/s12887-019-1762-6

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