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Published in: Intensive Care Medicine 7/2004

01-07-2004 | Special Article

Year in review in intensive care medicine: 2003. II. Brain injury, hemodynamics, gastrointestinal tract, renal failure, metabolism, trauma, and postoperative

Authors: Edward Abraham, Peter Andrews, Massimo Antonelli, Laurent Brochard, Christian Brun-Buisson, Geoffrey Dobb, Jean-Yves Fagon, Johan Groeneveld, Jordi Mancebo, Philipp Metnitz, Stefano Nava, Michael Pinsky, Peter Radermacher, Marco Ranieri, Christian Richard, Robert Tasker, Benoit Vallet

Published in: Intensive Care Medicine | Issue 7/2004

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Excerpt

Considerable interest remains in measuring cerebral blood flow and in ascertaining the adequacy of cerebral blood flow, cerebral perfusion pressure, and substrate delivery/metabolism after acute brain injury. Researchers today are dogged by the same problem that faced pioneers many decades ago: that the brain is inaccessible within the skull. The combined technologies of magnetic resonance imaging, positron emission tomography, transcranial Doppler ultrasound, near infrared reflectance spectroscopy (NIRS), and cerebral microdialysis offer the prospect of better understanding the basic regulatory mechanisms that remain to be elucidated in neurophysiology. Cross-sectional imaging/signals offer the potential for spatial resolution but cannot provide the vigilance desirable in critical care monitoring, and bedside monitors measure either indirect variables or regional variables that may not accurately reflect other brain subregions. What is required is a “bottom-up” modeling exercise, which generates a model of cerebral autoregulation, from cellular metabolism to global cerebral perfusion. …
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Metadata
Title
Year in review in intensive care medicine: 2003. II. Brain injury, hemodynamics, gastrointestinal tract, renal failure, metabolism, trauma, and postoperative
Authors
Edward Abraham
Peter Andrews
Massimo Antonelli
Laurent Brochard
Christian Brun-Buisson
Geoffrey Dobb
Jean-Yves Fagon
Johan Groeneveld
Jordi Mancebo
Philipp Metnitz
Stefano Nava
Michael Pinsky
Peter Radermacher
Marco Ranieri
Christian Richard
Robert Tasker
Benoit Vallet
Publication date
01-07-2004
Publisher
Springer-Verlag
Published in
Intensive Care Medicine / Issue 7/2004
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI
https://doi.org/10.1007/s00134-004-2339-9

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