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BMC Oral Health

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Open Access 01-12-2023 | Wound Debridement | Research

A retrospective analysis for the management of oromaxillofacial invasive mucormycosis and systematic literature review

Authors: Chen-xi Li, Zhong-cheng Gong, Parekejiang Pataer, Bo Shao, Chang Fang

Published in: BMC Oral Health | Issue 1/2023

Abstract

Purpose

Mucormycosis is a type of fatal infectious disease, rarely involved in the oromaxillofacial region. This study aimed to describe a series of 7 cases with oromaxillofacial mucormycosis and to discuss the epidemiology, clinical features, and treatment algorithm thereof.

Methodology

Seven patients in the author’s affiliation have been treated. They were assessed and presented as per their diagnostic criteria, surgical approach, and mortality rates. Reported cases of mucormycosis originally happened in craniomaxillofacial region were synthesized through a systematic review so as to better discuss its pathogenesis, epidemiology, and management.

Results

Six patients had a primary metabolic disorder, and one immunocompromised patient had a history of aplastic anemia. The criteria for a positive diagnosis of invasive mucormycosis were based on clinical presentation of signs and symptoms, and a biopsy for microbiological culture and histopathologic analysis. Each patient used antifungal drugs and five of them also underwent surgical resection at the same time. Four patients died due to the unregulated spread of mucormycosis, and one patient died owing to her main disease.

Conclusions

Although uncommon in clinical practice setting, mucormycosis should be of great concern in oral and maxillofacial surgery, due to the life-threatening possibility of this disease. The knowledge of early diagnosis and prompt treatment is of utmost importance for saving lives.

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Title: A retrospective analysis for the management of oromaxillofacial invasive mucormycosis and systematic literature review
Authors: Chen-xi Li
Zhong-cheng Gong
Parekejiang Pataer
Bo Shao
Chang Fang
Publication date: 01-12-2023
Publisher: BioMed Central
Keyword: Wound Debridement
Published in: BMC Oral Health / Issue 1/2023
Electronic ISSN: 1472-6831
DOI: https://doi.org/10.1186/s12903-023-02823-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

A retrospective analysis for the management of oromaxillofacial invasive mucormycosis and systematic literature review

Abstract

Purpose

Methodology

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methodology

Results

Conclusions

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