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Published in: Malaria Journal 1/2008

Open Access 01-12-2008 | Research

Willingness and ability to pay for artemisinin-based combination therapy in rural Tanzania

Authors: Eleonor C Saulo, Birger C Forsberg, Zul Premji, Scott M Montgomery, Anders Björkman

Published in: Malaria Journal | Issue 1/2008

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Abstract

Background

The aim of this study was to analyse willingness to pay (WTP) and ability to pay (ATP) for ACT for children below five years of age in a rural setting in Tanzania before the introduction of artemisinin-based combination therapy (ACT) as first-line treatment for uncomplicated malaria. Socio-economic factors associated with WTP and expectations on anti-malaria drugs, including ACT, were also explored.

Methods

Structured interviews and focus group discussions were held with mothers, household heads, health-care workers and village leaders in Ishozi, Gera and Ishunju wards in north-west Tanzania in 2004. Contingent valuation method (CVM) was used with "take-it-or-leave-it" as the eliciting method, expressed as WTP for a full course of ACT for a child and households' opportunity cost of ACT was used to assess ATP. The study included descriptive analyses with multivariate adjustment for potential confounding factors.

Results

Among 265 mothers and household heads, 244 (92%, CI = 88%–95%) were willing to pay Tanzanian Shillings (TSh) 500 (US$ 0.46) for a child's dose of ACT, but only 55% (49%–61%) were willing to pay more than TSh 500. Mothers were more often willing to pay than male household heads (adjusted odds ratio = 2.1, CI = 1.2–3.6). Socio-economic status had no significant effect on WTP. The median annual non-subsidized ACT cost for clinical malaria episodes in an average household was calculated as US$ 6.0, which would represent 0.9% of the average total consumption expenditures as estimated from official data in 2001. The cost of non-subsidized ACT represented 7.0% of reported total annual expenditure on food and 33.0% of total annual expenditure on health care.
"Rapid effect," "no adverse effect" and "inexpensive" were the most desired features of an anti-malarial drug.

Conclusion

WTP for ACT in this study was less than its real cost and a subsidy is, therefore, needed to enable its equitable affordability. The decision taken in Tanzania to subsidize Coartem® fully at governmental health care facilities and at a consumer price of TSh 300–500 (US$ 0.28–0.46) at special designated shops through the programme of Accredited Drug Dispensing Outlets (ADDOs) appears to be well founded.
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Literature
1.
go back to reference Jowett M, Miller NJ: The financial burden of malaria in Tanzania: implications for future government policy. Int J Health Plann Manage. 2005, 20: 67-84. 10.1002/hpm.796.CrossRef Jowett M, Miller NJ: The financial burden of malaria in Tanzania: implications for future government policy. Int J Health Plann Manage. 2005, 20: 67-84. 10.1002/hpm.796.CrossRef
2.
go back to reference Trape JF, Pison G, Preziosi MP, Enel C, Desgrees du Lou A, Delaunay V, Samb B, Lagarde E, Molez JF, Simondon F: Impact of chloroquine resistance on malaria mortality. C R Acad Sciences III. 1998, 321: 689-697. 10.1016/S0764-4469(98)80009-7.CrossRef Trape JF, Pison G, Preziosi MP, Enel C, Desgrees du Lou A, Delaunay V, Samb B, Lagarde E, Molez JF, Simondon F: Impact of chloroquine resistance on malaria mortality. C R Acad Sciences III. 1998, 321: 689-697. 10.1016/S0764-4469(98)80009-7.CrossRef
3.
go back to reference Bjorkman A: Malaria associated anaemia, drug resistance and anti-malarial combination therapy. Int J Parasitol. 2002, 32: 1637-1643. 10.1016/S0020-7519(02)00192-3.CrossRefPubMed Bjorkman A: Malaria associated anaemia, drug resistance and anti-malarial combination therapy. Int J Parasitol. 2002, 32: 1637-1643. 10.1016/S0020-7519(02)00192-3.CrossRefPubMed
4.
go back to reference WHO: Guidelines for treatment of malaria. 2006, Geneva: World Health Organization WHO: Guidelines for treatment of malaria. 2006, Geneva: World Health Organization
5.
go back to reference Adjuik M, Agnamey P, Babiker A, Borrmann S, Brasseur P, Cisse M, Cobelens F, Diallo S, Faucher JF, Garner P, Gikunda S, Kremsner PG, Krishna S, Lell B, Loolpapit M, Matsiegui PB, Missinou MA, Mwanza J, Ntoumi F, Olliaro P, Osimbo P, Rezbach P, Some E, Taylor WRJ: Amodiaquine-artesunate versus amodiaquine for uncomplicated Plasmodium falciparum malaria in African children: a randomized, multicentre trial. Lancet. 2002, 359: 1365-1372. 10.1016/S0140-6736(02)08348-4.CrossRefPubMed Adjuik M, Agnamey P, Babiker A, Borrmann S, Brasseur P, Cisse M, Cobelens F, Diallo S, Faucher JF, Garner P, Gikunda S, Kremsner PG, Krishna S, Lell B, Loolpapit M, Matsiegui PB, Missinou MA, Mwanza J, Ntoumi F, Olliaro P, Osimbo P, Rezbach P, Some E, Taylor WRJ: Amodiaquine-artesunate versus amodiaquine for uncomplicated Plasmodium falciparum malaria in African children: a randomized, multicentre trial. Lancet. 2002, 359: 1365-1372. 10.1016/S0140-6736(02)08348-4.CrossRefPubMed
6.
go back to reference Hien TT, Dolecek C, Mai PP, Dung NT, Truong NT, Thai LH, An DTH, Thanh TT, Stepniewska K, White NJ, Farrar J: Dihydroartemisinin-piperaquine against multidrug-resistant Plasmodium falciparum malaria in Vietnam: randomised clinical trial. Lancet. 2004, 363: 18-22. 10.1016/S0140-6736(03)15163-X.CrossRef Hien TT, Dolecek C, Mai PP, Dung NT, Truong NT, Thai LH, An DTH, Thanh TT, Stepniewska K, White NJ, Farrar J: Dihydroartemisinin-piperaquine against multidrug-resistant Plasmodium falciparum malaria in Vietnam: randomised clinical trial. Lancet. 2004, 363: 18-22. 10.1016/S0140-6736(03)15163-X.CrossRef
7.
go back to reference Martensson A, Stromberg J, Sisowath C, Msellem MI, Gil JP, Montgomery SM, Olliaro P, Ali AS, Björkman A: Efficacy of artesunate plus amodiaquine versus that of artemether-lumefantrine for the treatment of uncomplicated childhood Plasmodium falciparum malaria in Zanzibar, Tanzania. Clin Infect Dis. 2005, 41: 1079-1086. 10.1086/444460.CrossRefPubMed Martensson A, Stromberg J, Sisowath C, Msellem MI, Gil JP, Montgomery SM, Olliaro P, Ali AS, Björkman A: Efficacy of artesunate plus amodiaquine versus that of artemether-lumefantrine for the treatment of uncomplicated childhood Plasmodium falciparum malaria in Zanzibar, Tanzania. Clin Infect Dis. 2005, 41: 1079-1086. 10.1086/444460.CrossRefPubMed
8.
go back to reference WHO: Anti-malarial drug combination therapy. 2001, Report of a WHO technical consultation. Geneva WHO: Anti-malarial drug combination therapy. 2001, Report of a WHO technical consultation. Geneva
9.
go back to reference Adjuik M, Agnamey P, Babiker A, Baptista J, Borrmann S, Brasseur P, Carnevale P, Cisse M, Collins R, Alessandro UD, Day N, Boom W de, Doherty T, Dorsey G, Garner P, Gikunda S, Gil V, Greenwood B, Guthmann JP, Henry MC, Kamya MR, Kremsner PG, Konaté E, Krishna S, Lalloo D, Lange P, Loolpapit M: Artesunate combinations for treatment of malaria: meta-analysis. Lancet. 2004, 363: 9-17. 10.1016/S0140-6736(03)15162-8.CrossRefPubMed Adjuik M, Agnamey P, Babiker A, Baptista J, Borrmann S, Brasseur P, Carnevale P, Cisse M, Collins R, Alessandro UD, Day N, Boom W de, Doherty T, Dorsey G, Garner P, Gikunda S, Gil V, Greenwood B, Guthmann JP, Henry MC, Kamya MR, Kremsner PG, Konaté E, Krishna S, Lalloo D, Lange P, Loolpapit M: Artesunate combinations for treatment of malaria: meta-analysis. Lancet. 2004, 363: 9-17. 10.1016/S0140-6736(03)15162-8.CrossRefPubMed
10.
go back to reference Novartis : Novartis announces initiative to improve access to state-of-the-art anti-malarial treatment Coartem®. Basel. 2006 Novartis : Novartis announces initiative to improve access to state-of-the-art anti-malarial treatment Coartem®. Basel. 2006
11.
go back to reference Sanofi-Aventis : Collaborative agreement between the DNDi foundation and Sanofi-aventis to develop a new, easy-to-use malaria drug at target price below one dollar. Paris. 2005 Sanofi-Aventis : Collaborative agreement between the DNDi foundation and Sanofi-aventis to develop a new, easy-to-use malaria drug at target price below one dollar. Paris. 2005
12.
go back to reference Onwujekwe O, Uzochukwu B, Shu E, Ibeh C, Okonkwo P: Is combination therapy for malaria based on user-fees worthwhile and equitable to consumers? Assessment of costs and willingness to pay in Southeast Nigeria. Acta Trop. 2004, 91: 101-115. 10.1016/j.actatropica.2004.03.005.CrossRefPubMed Onwujekwe O, Uzochukwu B, Shu E, Ibeh C, Okonkwo P: Is combination therapy for malaria based on user-fees worthwhile and equitable to consumers? Assessment of costs and willingness to pay in Southeast Nigeria. Acta Trop. 2004, 91: 101-115. 10.1016/j.actatropica.2004.03.005.CrossRefPubMed
13.
go back to reference Wiseman V, Onwujekwe O, Matovu F, Mutabingwa TK, Whitty CJ: Differences in willingness to pay for artemisinin-based combinations or monotherapy: experiences from the United Republic of Tanzania. Bull World Health Organ. 2005, 83: 845-852.PubMedCentralPubMed Wiseman V, Onwujekwe O, Matovu F, Mutabingwa TK, Whitty CJ: Differences in willingness to pay for artemisinin-based combinations or monotherapy: experiences from the United Republic of Tanzania. Bull World Health Organ. 2005, 83: 845-852.PubMedCentralPubMed
14.
go back to reference MARA: Tanzania: Distribution of Endemic Malaria. 2005, Durban: Mapping Malaria Risk in Africa MARA: Tanzania: Distribution of Endemic Malaria. 2005, Durban: Mapping Malaria Risk in Africa
15.
go back to reference Diener A, O'Brien B, Gafni A: Health care contingent valuation studies: a review and classification of the literature. Health Econ. 1998, 7: 313-326. 10.1002/(SICI)1099-1050(199806)7:4<313::AID-HEC350>3.0.CO;2-B.CrossRefPubMed Diener A, O'Brien B, Gafni A: Health care contingent valuation studies: a review and classification of the literature. Health Econ. 1998, 7: 313-326. 10.1002/(SICI)1099-1050(199806)7:4<313::AID-HEC350>3.0.CO;2-B.CrossRefPubMed
16.
go back to reference Klose T: Review: The contingent valuation method in health care. Health Policy. 1999, 47: 97-123. 10.1016/S0168-8510(99)00010-X.CrossRefPubMed Klose T: Review: The contingent valuation method in health care. Health Policy. 1999, 47: 97-123. 10.1016/S0168-8510(99)00010-X.CrossRefPubMed
17.
go back to reference Bhatia MR, Fox-Rushby JA: Willingness to pay for treated mosquito nets in Surat, India: the design and descriptive analysis of a household survey. Health Policy Plan. 2002, 17: 402-411. 10.1093/heapol/17.4.402.CrossRefPubMed Bhatia MR, Fox-Rushby JA: Willingness to pay for treated mosquito nets in Surat, India: the design and descriptive analysis of a household survey. Health Policy Plan. 2002, 17: 402-411. 10.1093/heapol/17.4.402.CrossRefPubMed
18.
go back to reference Deaton A, Zaidi S: Adjusting for household composition. Guidelines for constructing consumption aggregates for welfare analysis. 2002, Washington DC: World Bank Publication Deaton A, Zaidi S: Adjusting for household composition. Guidelines for constructing consumption aggregates for welfare analysis. 2002, Washington DC: World Bank Publication
19.
go back to reference Premji Z, Lubega P, Hamisi Y, Mchopa E, Minjas J, Checkley W, Shiff C: Changes in malaria associated morbidity in children using insecticide treated mosquito nets in the Bagamoyo district of coastal Tanzania. Trop Med Parasitol. 1995, 46: 147-153.PubMed Premji Z, Lubega P, Hamisi Y, Mchopa E, Minjas J, Checkley W, Shiff C: Changes in malaria associated morbidity in children using insecticide treated mosquito nets in the Bagamoyo district of coastal Tanzania. Trop Med Parasitol. 1995, 46: 147-153.PubMed
20.
go back to reference Alilio M, Kitua A, Njunwa K, Medina M, Ronn AM, Mhina J, Msuya F, Mahundi J, Depinay JM, Whyte S, Krasnik A, Bygbjerg IBC: Malaria control at the district level in Tanzania: The case of the Muheza district in northeastern Tanzania. Am J Trop Med Hyg. 2004, 71: 205-213. Alilio M, Kitua A, Njunwa K, Medina M, Ronn AM, Mhina J, Msuya F, Mahundi J, Depinay JM, Whyte S, Krasnik A, Bygbjerg IBC: Malaria control at the district level in Tanzania: The case of the Muheza district in northeastern Tanzania. Am J Trop Med Hyg. 2004, 71: 205-213.
21.
go back to reference NBS: Household Budget Survey 2000/2001. 2003, Dar es Salaam: National Bureau of Statistics Tanzania NBS: Household Budget Survey 2000/2001. 2003, Dar es Salaam: National Bureau of Statistics Tanzania
22.
go back to reference CIA: The World Factbook. 2006, Central Intelligence Agency CIA: The World Factbook. 2006, Central Intelligence Agency
23.
go back to reference Morel CM, Lauer JA, Evans DB: Cost effectiveness analysis of strategies to combat malaria in developing countries. Br Med J. 2005, 331: 1299-1302. 10.1136/bmj.38639.702384.AE.CrossRef Morel CM, Lauer JA, Evans DB: Cost effectiveness analysis of strategies to combat malaria in developing countries. Br Med J. 2005, 331: 1299-1302. 10.1136/bmj.38639.702384.AE.CrossRef
24.
go back to reference Foster V, Bateman IJ, Harley D: Real and hypothetical willingness to pay for environmental preservation: A non-experimental comparison. J Agric Econ. 1997, 48: 123-138. 10.1111/j.1477-9552.1997.tb01140.x.CrossRef Foster V, Bateman IJ, Harley D: Real and hypothetical willingness to pay for environmental preservation: A non-experimental comparison. J Agric Econ. 1997, 48: 123-138. 10.1111/j.1477-9552.1997.tb01140.x.CrossRef
25.
go back to reference Blumenschein K, Blomquist GC, Liljas B, Conor RM: Experimental results on expressed certainty and hypothetical bias in contingent valuation. South Econ J. 1998, 65: 169-177. 10.2307/1061360.CrossRef Blumenschein K, Blomquist GC, Liljas B, Conor RM: Experimental results on expressed certainty and hypothetical bias in contingent valuation. South Econ J. 1998, 65: 169-177. 10.2307/1061360.CrossRef
26.
go back to reference Blumenschein K, Johannesson M, Yokoyama KK, Freeman PR: Hypothetical versus real willingness to pay in the health care sector: results from a field experiment. J Health Econ. 2001, 20: 441-457. 10.1016/S0167-6296(01)00075-3.CrossRefPubMed Blumenschein K, Johannesson M, Yokoyama KK, Freeman PR: Hypothetical versus real willingness to pay in the health care sector: results from a field experiment. J Health Econ. 2001, 20: 441-457. 10.1016/S0167-6296(01)00075-3.CrossRefPubMed
27.
go back to reference Onwujekwe O, Hanson K, Fox-Rushby J: Do divergences between stated and actual willingness to pay signify the existence of bias in contingent valuation surveys?. Soc Sci Med. 2005, 60: 525-536. 10.1016/j.socscimed.2004.05.023.CrossRefPubMed Onwujekwe O, Hanson K, Fox-Rushby J: Do divergences between stated and actual willingness to pay signify the existence of bias in contingent valuation surveys?. Soc Sci Med. 2005, 60: 525-536. 10.1016/j.socscimed.2004.05.023.CrossRefPubMed
28.
go back to reference Whitehead JC, Hoban TJ: Testing for temporal reliability in contingent valuation with time for changes in factors affecting demand. Land Econ. 1999, 75: 453-465. 10.2307/3147190.CrossRef Whitehead JC, Hoban TJ: Testing for temporal reliability in contingent valuation with time for changes in factors affecting demand. Land Econ. 1999, 75: 453-465. 10.2307/3147190.CrossRef
29.
go back to reference Kealy MJ, Dovidio JF, Rockel ML: Accuracy in valuation is a matter of degree. Land Econ. 1988, 64: 158-171. 10.2307/3146821.CrossRef Kealy MJ, Dovidio JF, Rockel ML: Accuracy in valuation is a matter of degree. Land Econ. 1988, 64: 158-171. 10.2307/3146821.CrossRef
30.
go back to reference Donaldson C, Farrar S, Mapp T, Walker A, Macphee S: Assessing community values in health care: is the "willingness to pay" method feasible?. Health Care Anal. 1997, 5: 7-29. 10.1007/BF02678452.CrossRefPubMed Donaldson C, Farrar S, Mapp T, Walker A, Macphee S: Assessing community values in health care: is the "willingness to pay" method feasible?. Health Care Anal. 1997, 5: 7-29. 10.1007/BF02678452.CrossRefPubMed
31.
go back to reference Russel S: Ability to pay for health care: concepts and evidence. Health Policy Plan. 1996, 11: 219-237. 10.1093/heapol/11.3.219.CrossRef Russel S: Ability to pay for health care: concepts and evidence. Health Policy Plan. 1996, 11: 219-237. 10.1093/heapol/11.3.219.CrossRef
32.
go back to reference Bayoumi AM: The measurement of contingent valuation for health economics. Pharmacoeconomics. 2004, 22: 691-700. 10.2165/00019053-200422110-00001.CrossRefPubMed Bayoumi AM: The measurement of contingent valuation for health economics. Pharmacoeconomics. 2004, 22: 691-700. 10.2165/00019053-200422110-00001.CrossRefPubMed
33.
go back to reference Mitchell RC, Carson RT: Strategic behavior and contingent valuation studies. Using surveys to value public goods: the contingent valuation method. 1989, Washington DC: Resources for the future/Johns Hopkins University Press Mitchell RC, Carson RT: Strategic behavior and contingent valuation studies. Using surveys to value public goods: the contingent valuation method. 1989, Washington DC: Resources for the future/Johns Hopkins University Press
35.
go back to reference Goodman CA, Coleman PG, Mills AJ: Cost-effectiveness of malaria control in sub-Saharan Africa. Lancet. 1999, 354: 378-385. 10.1016/S0140-6736(99)02141-8.CrossRef Goodman CA, Coleman PG, Mills AJ: Cost-effectiveness of malaria control in sub-Saharan Africa. Lancet. 1999, 354: 378-385. 10.1016/S0140-6736(99)02141-8.CrossRef
Metadata
Title
Willingness and ability to pay for artemisinin-based combination therapy in rural Tanzania
Authors
Eleonor C Saulo
Birger C Forsberg
Zul Premji
Scott M Montgomery
Anders Björkman
Publication date
01-12-2008
Publisher
BioMed Central
Published in
Malaria Journal / Issue 1/2008
Electronic ISSN: 1475-2875
DOI
https://doi.org/10.1186/1475-2875-7-227

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