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BMC Infectious Diseases
Published in: BMC Infectious Diseases 1/2015

Open Access 01-12-2015 | Research article

Why are people with dengue dying? A scoping review of determinants for dengue mortality

Authors: Mabel Carabali, Libia Milena Hernandez, Maria Jose Arauz, Luis Angel Villar, Valéry Ridde

Published in: BMC Infectious Diseases | Issue 1/2015

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Abstract

Background

Dengue is a viral disease whose clinical spectrum ranges from unapparent to severe forms and fatal outcomes. Although dengue death is 99 % avoidable, every year around 20,000 deaths are estimated to occur in more than 100 countries. We consider that, along with biological factors, social determinants of health (SDHs) are related to dengue deaths as well.

Methods

A scoping review was conducted to explore what has been written about the role of SDHs in dengue mortality. The inclusion criteria were that documents (grey or peer-reviewed) had to include information about dengue fatal cases in humans and be published between 1997 and 2013 and written in English, Spanish, Portuguese or French. The search was conducted using a set of key words related to dengue mortality in several electronic databases: PubMed, LILACS, COCHRANE, Scielo, Science Direct, WHOLIS, OpenGrey, OpenSingle and Google Scholar. Information on SDHs was categorized under individual, social and environmental, and health systems dimensions. A summative content analysis using QDA Miner was conducted to assess the frequency of information on SDHs and its contextual meaning in the reviewed literature. The role of each SDH in dengue mortality was assessed using content analysis results.

Results

From a total of 971 documents retrieved, 78 met the criteria. Those documents were published in the Americas region (50.0 %), Asia (38.4 %), Europe (9.0 %) and Africa (2.6 %). The described SDHs related to dengue deaths included, in the individual dimension: age, ethnicity, education, type of infection and immunological status; and in the social dimension: poverty and care-seeking behavior. The health systems dimension included access, opportunity, and quality of care, as well as health staff knowledge. Ethnicity was considered a determinant that depends on cultural and socioeconomic conditions.

Conclusions

Along with biological factors, there are several SDHs related to dengue mortality. However, only a few of these have been systematically analyzed, suggesting the need for more studies on this subject to inform the design and implementation of sustainable interventions to decrease dengue mortality. These findings nevertheless provide a better understanding of the non-biological factors involved in dengue mortality.
Appendix
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Literature
1.
WHO. Global strategy for dengue prevention and control 2012–2020. Geneva: WHO. World Health Organization; 2012.
2.
Gubler DJ. Dengue/dengue haemorrhagic fever: history and current status. Novartis Found Symp. 2006;277:3–16. discussion 16–22, 71–13, 251–253.PubMed
3.
Murray NEA, Quam MB, Wilder-Smith A. Epidemiology of dengue: past, present and future prospects. Clin Epidemiol. 2013;5:299.PubMedPubMedCentral
4.
Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, et al. The global distribution and burden of dengue. Nature. 2013;496:504–7.PubMedPubMedCentral
5.
Messina JP, Brady OJ, Scott TW, Zou C, Pigott DM, Duda KA, et al. Global spread of dengue virus types: mapping the 70 year history. Trends Microbiol. 2014;22(3):138–46.PubMedPubMedCentral
6.
Guzman MG, Halstead SB, Artsob H, Buchy P, Farrar J, Gubler DJ, et al. Dengue: a continuing global threat. Nat Rev Microbiol. 2010;8:S7–16.PubMedPubMedCentral
7.
Gubler DJ. Epidemic dengue/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century. Trends Microbiol. 2002;10(2):100–3.PubMed
8.
Tuiskunen Bäck A, Lundkvist Å. Dengue viruses -- an overview. Infect Ecology Epidemiol. 2013;3(2013):18839.
9.
Rodriguez-Roche R, Gould EA. Understanding the dengue viruses and progress towards their control. Bio Med Res Int. 2013;2013:20.
10.
Huy NT, Van Giang T, Thuy DHD, Kikuchi M, Hien TT, Zamora J, et al. Factors associated with dengue shock syndrome: a systematic review and meta-analysis. PLoS Negl Trop Dis. 2013;7(9), e2412.PubMedPubMedCentral
11.
Cafferata ML, Bardach A, Rey-Ares L, Alcaraz A, Cormick G, Gibbons L, et al. Dengue epidemiology and burden of disease in Latin America and the Caribbean: a systematic review of the literature and meta-analysis. Value in Health Regional Issues. 2013;2(3):347–56.
12.
13.
WHO. Dengue and severe dengue/Global burden of dengue. Fact sheet N°117. Geneva: World Health Organization; 2012.
14.
Guzmán MG, Kouri G. Dengue: an update. Lancet Infect Dis. 2002;2(1):33–42.PubMed
15.
San Martín JL, Brathwaite O, Zambrano B, Solórzano JO, Bouckenooghe A, Dayan GH, et al. The epidemiology of dengue in the Americas over the last three decades: a worrisome reality. Am J Trop Med Hyg. 2010;82(1):128–35.PubMedPubMedCentral
16.
Solar O, Irwin A. A conceptual framework for action on the social determinants of health. In: Discussion Paper Series on Social Determinants of Health, No 2. Geneva: World Health Organization; 2010.
17.
Marmot M, Wilkinson R. Social determinants of health: the solid facts. 2nd ed. Copenhagen: World Health Organization; 2003.
18.
Commission on Social Determinants of Health-CSDH. Closing the gap in a generation: health equity through action on the social determinants of health. Final report of the Commission on Social Determinants of Health. Geneva: World Health Organization; 2008. p. 256.
19.
Blas E, Kurup AS. Equity, social determinants and public health programmes. Geneva: World Health Organization; 2010.
20.
Carabalí JM, Hendrickx D. Dengue and health care access: the role of social determinants of health in dengue surveillance in Colombia. Glob Health Promot. 2012;19(4):45–50.PubMed
21.
Khun S, Manderson L. Poverty, user fees and ability to pay for health care for children with suspected dengue in rural Cambodia. Int J Equity in Health. 2008;7(1):10.
22.
Arksey H, O'Malley L. Scoping studies: towards a methodological framework. Int J Social Res Methodol. 2005;8(1):19–32.
23.
WHO. Dengue guidelines for diagnosis, treatment, prevention and control - New edition. Geneva: World Health Organization; 2009.
24.
von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: Guidelines for reporting observational studies. Prev Med. 2007;45(4):247–51.
25.
Hsieh H-F, Shannon SE. Three approaches to qualitative content analysis. Qual Health Res. 2005;15(9):1277–88.PubMed
26.
World Health Organization. Dengue: guidelines for diagnosis, treatment, prevention and control. 2nd Edition, WHO Library Cataloguing-in-Publication Data Geneva: World Health Organization; 1997.
27.
Cardoso IM, Cabidelle ASA, Borges PCL, Lang CF, Calenti FG, Nogueira LO, et al. Dengue: clinical forms and risk groups in a high incidence city in the southeastern region of Brazil. Rev Soc Bras Med Trop. 2011;44(4):430–5.PubMed
28.
Corwin AL, Larasati RP, Bangs MJ, Wuryadi S, Arjoso S, Sukri N, et al. Epidemic dengue transmission in southern Sumatra, Indonesia. Trans R Soc Trop Med Hyg. 2001;95(3):257–65.PubMed
29.
Guzmán MG, Alvarez M, Rodriguez R, Rosario D, Vázquez S, Valdés L, et al. Fatal dengue hemorrhagic fever in Cuba, 1997. Int J Infect Dis. 1999;3(3):130–5.PubMed
30.
Sam SS, Omar SF, Teoh BT, Abd-Jamil J, AbuBakar S. Review of Dengue hemorrhagic fever fatal cases seen among adults: a retrospective study. PLoS Negl Trop Dis. 2013;7(5), e2194.PubMedPubMedCentral
31.
Bunnag T, Kalayanarooj S. Dengue shock syndrome at the emergency room of Queen Sirikit National Institute of Child Health, Bangkok, Thailand. J Med Assoc Thai. 2011;94 Suppl 3:S57–63.PubMed
32.
Fajardo-Dolci G, Meljem-Moctezuma J, Vicente-González E, Venegas-Páez FV, Villalba-Espinoza I, Pérez-Cardoso AL, et al. Defunciones por dengue en México Análisis del año 2009. Rev Med Inst Mex Seguro Soc. 2012;50(6):589–98.PubMed
33.
Sharp TM, Hunsperger E, Santiago GA, Muñoz-Jordan JL, Santiago LM, Rivera A, et al. Virus-specific differences in rates of disease during the 2010 dengue epidemic in Puerto Rico. PLoS Negl Trop Dis. 2013;7(4), e2159.PubMedPubMedCentral
34.
Wang C-C, Lee I-K, Su M-C, Lin H-I, Huang Y-C, Liu S-F, et al. Differences in clinical and laboratory characteristics and disease severity between children and adults with dengue virus infection in Taiwan, 2002. Trans R Soc Trop Med Hyg. 2009;103(9):871–7.PubMed
35.
Md P, Figueiredo M. Mortalidade por dengue no estado da Bahia. Revista Baiana de Saúde Pública. 2011;35(3):687–94.
36.
Cordeiro MT, Schatzmayr HG, Nogueira RMR, Oliveira VF, Melo WT, Carvalho EF. Dengue and dengue hemorrhagic fever in the State of Pernambuco, 1995–2006. Rev Soc Bras Med Trop. 2007;40(6):605–11.PubMed
37.
González D, Castro OE, Kourí G, Perez J, Martinez E, Vazquez S, et al. Classical dengue hemorrhagic fever resulting from two dengue infections spaced 20 years or more apart: Havana, Dengue 3 epidemic, 2001–2002. Int J Infect Dis. 2005;9(5):280–5.PubMed
38.
Salgado DM, Panqueba CA, Vega MR, Garzón M, Castro D, Rodríguez JA. Mortalidad por dengue hemorrágico en niños en Colombia: más allá del choque / Dengue hemorrhagic fever mortality in children: beyond shock. Infectio. 2008;12(1):21–7.
39.
Contreras-Arita A, Villatoro-Godoy G. Perfil Clínico-epidemiológico del dengue hemorrágico en niños atendidos en el Hospital Materno Infantil. Rev Med Post Unah. 1999;4(2):122–8.
40.
Tomashek KM, Gregory CJ, Rivera Sanchez A, Bartek MA, Garcia Rivera EJ, Hunsperger E, et al. Dengue deaths in Puerto Rico: lessons learned from the 2007 epidemic. PLoS Negl Trop Dis. 2012;6(4), e1614.PubMedPubMedCentral
41.
Raghupathy R, Chaturvedi UC, Al-Sayer H, Elbishbishi EA, Agarwal R, Nagar R, et al. Elevated levels of IL-8 in dengue hemorrhagic fever. J Med Virol. 1998;56(3):280–5.PubMed
42.
Ahmed S, Mohammad WW, Hamid F, Akhter A, Afzal RK, Mahmood A. The 2011 dengue haemorrhagic fever outbreak in Lahore -- an account of clinical parameters and pattern of haemorrhagic complications. J College Physicians and Surgeons--Pakistan: JCPSP. 2013;23(7):463–7.
43.
Arismendi-Morillo G, Mauriello-Rivas C, Maldonado-Reverol M, Fernández-Abreu M, Larreal M, Torres-Nava G, et al. Correlación clínico-patológica en casos fatales de dengue en Maracaibo. Venezuela Revista Cubana de Medicina Tropical. 2011;63(1):44–51.PubMed
44.
Carod-Artal FJ, Wichmann O, Farrar J, Gascón J. Neurological complications of dengue virus infection. The Lancet Neurology. 2013;12(9):906–19.PubMed
45.
Mohamed NA, El-Raoof EA, Ibraheem HA. Respiratory manifestations of dengue fever in Taiz-Yemen. Egyptian Journal of Chest Diseases and Tuberculosis. 2013;62(2):319–23.
46.
Azevedo LS, Carvalho DB, Matuck T, Alvarenga MF, Morgado L, Magalhaes I, et al. Dengue in renal transplant patients: a retrospective analysis. Transplantation. 2007;84(6):792–4.PubMed
47.
Karunakaran A, Ilyas WM, Sheen SF, Jose NK, Nujum ZT. Risk factors of mortality among dengue patients admitted to a tertiary care setting in Kerala, India. J Infect Public Health. 2013;7(2):114–20.PubMed
48.
Chesneau P, Mehdaoui H, Drault JN, de Heaulmes O, Flament F, Elisabeth L. Dengue hémorragique chez un patient traité au long cours par un antiagrégant plaquettaire : à propos d’un cas mortel en Martinique. Réanimation Urgences. 1998;7(6, Part 1):665–7.
49.
Adam I, Jumaa AM, Elbashir HM, Karsany MS. Maternal and perinatal outcomes of dengue in PortSudan, Eastern Sudan. Virol J. 2010;7:153.PubMedPubMedCentral
50.
Pouliot SH, Xiong X, Harville E, Paz-Soldan V, Tomashek KM, Breart G, et al. Maternal dengue and pregnancy outcomes: a systematic review. Obstet Gynecol Surv. 2010;65(2):107–18.PubMed
51.
Mota AKM, Miranda Filho AL, Saraceni V, Koifman S. Mortalidade materna e incidência de dengue na Região Sudeste do Brasil: estudo ecológico no período 2001–2005. Cad Saude Publica. 2012;28(6):1057–66.PubMed
52.
Jackson ST, Mullings A, Bennett F, Khan C, Gordon-Strachan G, Rhoden T. Dengue infection in patients presenting with neurological manifestations in a dengue endemic population. West Indian Med J. 2008;57(4):373–6.PubMed
53.
Verma R, Varatharaj A. Epilepsia partialis continua as a manifestation of dengue encephalitis. Epilepsy Behav. 2011;20(2):395–7.PubMed
54.
Tsai J-J, Hsieh M-H, Liu L-T, Hsiao H-M, Perng GC. Mortality from septic shock in a dengue infected patient: a case report. Southeast Asian J Trop Med Public Health. 2013;44(4):623–9.PubMed
55.
Lee IK, Liu JW, Yang KD. Fatal dengue hemorrhagic fever in adults: emphasizing the evolutionary pre-fatal clinical and laboratory manifestations. PLoS Negl Trop Dis. 2012;6(2), e1532.PubMedPubMedCentral
56.
Arboleda M, Campuzano M, Restrepo BN, Cartagena G. Caracterización clínica de los casos de dengue hospitalizados en la E.S.E. Hospital “Antonio Roldán Betancur”, Apartadó, Antioquia, Colombia, 2000. Biomedica. 2006;26(2):286–94.PubMed
57.
Vita WP, Nicolai CCA, Azevedo MB, Souza MF, Baran M. Dengue: alertas clínicos e laboratoriais da evolução grave da doença. Rev Soc Bras Med Trop. 2009;7(1):11–4.
58.
Ron-Guerrero CS, Ron-Magaña AL. Dengue fatal: reporte de cuatro casos en Nayarit, México. Medicina Interna de México. 2011;27(4):386.
59.
Casali CG, Pereira MRR, Santos LMJG, Passos MNP, Fortes BDPMD, Ortiz Valencia LI, et al. A epidemia de dengue/dengue hemorrágico no município do Rio de Janeiro, 2001/2002. Rev Soc Bras Med Trop. 2004;37(4):296–9.PubMed
60.
Alejandria MM: Dengue haemorrhagic fever or dengue shock syndrome in children. Clinical Evidence 2009; published online 12 January 2009.
61.
Wichmann O, Hongsiriwon S, Bowonwatanuwong C, Chotivanich K, Sukthana Y, Pukrittayakamee S. Risk factors and clinical features associated with severe dengue infection in adults and children during the 2001 epidemic in Chonburi, Thailand. Trop Med Int Health. 2004;9(9):1022–9.PubMed
62.
Ocazionez RE, Cortes FM, Villar LA, Gomez SY. Temporal distribution of dengue virus serotypes in Colombian endemic area and dengue incidence. Re-introduction of dengue-3 associated to mild febrile illness and primary infection. Mem Inst Oswaldo Cruz. 2006;101(7):725–31.PubMed
63.
Méndez Á, González G. Manifestaciones clínicas inusuales del dengue hemorrágico en niños. Biomedica. 2006;26(1):61–70.PubMed
64.
Misra UK, Kalita J, Syam UK, Dhole TN. Neurological manifestations of dengue virus infection. J Neurol Sci. 2006;244(1–2):117–22.PubMed
65.
Chaudhuri M, Pahari A. Dengue: clinical issues in management. Apollo Medicine. 2005;2(4):364–73.
66.
Ho T-S, Wang S-M, Lin Y-S, Liu C-C. Clinical and laboratory predictive markers for acute dengue infection. J Biomed Sci. 2013;20(1):75.PubMedPubMedCentral
67.
Kamath SR, Ranjit S. Clinical features, complications and atypical manifestations of children with severe forms of dengue hemorrhagic fever in South India. Indian J Pediatr. 2006;73(10):889–95.PubMed
68.
Lee VJ, Lye DCB, Sun Y, Fernandez G, Ong A, Leo YS. Predictive value of simple clinical and laboratory variables for dengue hemorrhagic fever in adults. J Clin Virol. 2008;42(1):34–9.PubMed
69.
Rigau-Pérez JG. Clinical manifestations of dengue hemorrhagic fever in Puerto Rico, 1990–1991. Rev Panam Salud Publica. 1997;1(6):435–43.
70.
Rocha LA, Tauil PL. Dengue em criança: aspectos clínicos e epidemiológicos, Manaus, Estado do Amazonas, no período de 2006 e 2007. Rev Soc Bras Med Trop. 2009;42(1):18–22.PubMed
71.
Shamim M. Frequency, pattern and management of acute abdomen in dengue fever in Karachi, Pakistan. Asian J Surg. 2010;33(3):107–13.PubMed
72.
Sukri NC, Laras K, Wandra T, Didi S, Larasati RP, Rachdyatmaka JR, et al. Transmission of epidemic dengue hemorrhagic fever in easternmost Indonesia. Am J Trop Med Hyg. 2003;68(5):529–35.PubMed
73.
Almas A, Parkash O, Akhter J. Clinical factors associated with mortality in dengue infection at a tertiary care center. Southeast Asian J Trop Med Public Health. 2010;41(2):333–40.PubMed
74.
Araújo FMC, Araújo MS, Nogueira RMR, Brilhante RSN, Oliveira DN, Rocha MFG, et al. Central nervous system involvement in dengue: A study in fatal cases from a dengue endemic area. Neurology. 2012;78(10):736–42.PubMed
75.
Juneja D, Nasa P, Singh O, Javeri Y, Uniyal B, Dang R. Clinical profile, intensive care unit course, and outcome of patients admitted in intensive care unit with dengue. J Crit Care. 2011;26(5):449–52.PubMed
76.
Malavige GN, Velathanthiri VGNS, Wijewickrama ES, Fernando S, Jayaratne SD, Aaskov J, et al. Patterns of disease among adults hospitalized with dengue infections. QJM. 2006;99(5):299–305.PubMed
77.
Montenegro D, Lacerda HR, Lira TM, Oliveira DSC, Lima AAF, Guimarães MJB, et al. Aspectos clínicos e epidemiológicos da epidemia de dengue no Recife, PE, em 2002. Revista da Sociedade Brasileira de Medicini Tropical. 2006;39(1):9–13.
78.
Navarrete-Espinosa J, Gómez-Dantés H, Germán Celis-Quintal J, Vázquez-Martínez JL. Clinical profile of dengue hemorrhagic fever cases in Mexico. Salud Publica Mex. 2005;47(3):193–200.PubMed
79.
Nisalak A, Endy TP, Nimmannitya S, Kalayanarooj S, Thisayakorn U, Scott RM, et al. Serotype-splecific dengue virus circulation and dengue disease in Bangkok, Thailand from 1973 to 1999. Am J Trop Med Hyg. 2003;68(2):191–202.PubMed
80.
Ong A, Sandar M, Chen MI, Sin LY. Fatal dengue hemorrhagic fever in adults during a dengue epidemic in Singapore. Int J Infect Dis. 2007;11(3):263–7.PubMed
81.
Schmitz L, Prayag S, Varghese S, Jog S, Bhargav-Patil P, Yadav A, et al. Nonhematological organ dysfunction and positive fluid balance are important determinants of outcome in adults with severe dengue infection: a multicenter study from India. J Crit Care. 2011;26(5):441–8.PubMed
82.
Janssen HLA, Bienfait HP, Jansen CL, van Duinen SG, Vriesendorp R, Schimsheimer RJ, et al. Fatal cerebral oedema associated with primary dengue infection. J Infect. 1998;36(3):344–6.PubMed
83.
Pontes RJS, Ruffino-Netto A. Vigilância e busca ativa de casos suspeitos de dengue hemorrágico em Ribeirão Preto, São Paulo / Surveillance and active search system for suspect cases of hemorrhagic dengue in Ribeirão Preto, São Paulo. Rev Panam Salud Publica. 1997;11(3):186–92.
84.
Lee C-H, Teo C, Low AF. Fulminant dengue myocarditis masquerading as acute myocardial infarction. Int J Cardiol. 2009;136(3):e69–71.PubMed
85.
Marques N, Gan V, Leo Y-S. Dengue myocarditis in Singapore: two case reports. Infection. 2013;41(3):709–14.PubMed
86.
Mok Y, Quah J, Siau C. A rare but potentially lethal complication of dengue. Asian Pacific J Tropical Med. 2013;6(6):500–1.
87.
Teixeira MG, Costa MCN, Barreto F, Barreto ML. Dengue: twenty-five years since reemergence in Brazil: [review] / Dengue: vinte e cinco anos da reemergência no Brasil: [revisão]. Cad Saude Publica. 2009;25(supl.1):S7–18.PubMed
88.
Moraes GH, de Fatima DE, Duarte EC. Determinants of mortality from severe dengue in Brazil: a population-based case–control study. Am J Trop Med Hyg. 2013;88(4):670–6.PubMed
89.
Jensenius M, Berild D, Ormaasen V, Mæhlen J, Lindegren G, Falk KI. Fatal subarachnoidal haemorrhage in a Norwegian traveller with dengue virus infection. Scand J Infect Dis. 2007;39(3):272–4.PubMed
90.
Huhtamo E, Vuorinen S, Uzcátegui NY, Vapalahti O, Haapasalo H, Lumio J. Fatal dengue virus infection in a Finnish traveler. J Clin Virol. 2006;37(4):323–6.PubMed
91.
Mia MS, Begum RA, Er AC, Abidin RDZRZ, Pereira JJ. Trends of dengue infections in Malaysia, 2000–2010. Asian Pacific J Tropical Med. 2013;6(6):462–6.
92.
Díaz-Quijano FA, Waldman EA. Factors associated with dengue mortality in Latin America and the Caribbean, 1995–2009: an ecological study. Am J Trop Med Hyg. 2012;86(2):328–34.PubMedPubMedCentral
93.
Figueiró AC, Hartz ZMA, Brito CAA, Samico I, Siqueira Filha NT, Cazarin G, et al. Óbito por dengue como evento sentinela para avaliação da qualidade da assistência: estudo de caso em dois municípios da Região Nordeste, Brasil, 2008. Cad Saude Publica. 2011;27(12):2373–85.PubMed
94.
Chakravarti A, Arora R, Luxemburger C. Fifty years of dengue in India. Trans R Soc Trop Med Hyg. 2012;106(5):273–82.PubMed
95.
Larrieu S, Cassadou S, Rosine J, Chappert JL, Blateau A, Ledrans M, et al. Lessons raised by the major 2010 dengue epidemics in the French West Indies. Acta Trop. 2014;131:37–40.PubMed
96.
Nogueira RMR, Araújo JMG, Schatzmayr HG. Dengue viruses in Brazil, 1986–2006. Rev Panam Salud Publica. 2007;22(5):358–63.PubMed
97.
Souza TBB, Dias JP. Perfil epidemiológico da dengue no Município de Itabuna (BA), 2000 jun. 2009. Revista Baiana de Saúde Pública. 2010;34:3.
98.
Guzmán MG, Kourí G, Valdés L, Bravo J, Vázquez S, Halstead S. Aumento de la gravedad de las infecciones secundarias por dengue-2: tasa de mortalidad en los brotes cubanos de 1981 y 1997. Revista Panamerica de Salud Pública. 2002;11(4):223–7.
99.
Nogueira R, Filippis A, Coelho J, Sequeira P, Schatzmayr H, Paiva F, et al. Dengue virus infection of the central nervous system (CNS): a case report from Brazil. Southeast Asian J Trop Med Public Health. 2002;33(1):68–71.PubMed
100.
Nogueira R, Schatzmayr H, de Filippis A, dos Santos F, da Cunha R, Coelho J, et al. Dengue virus type 3, Brazil, 2002. Emerg Infect Dis. 2005;11(9):6.
101.
Ramos C, Sánchez G, Pando RH, Baquera J, Hernández D, Mota J, et al. Dengue virus in the brain of a fatal case of hemorrhagic dengue fever. J Neurovirol. 1998;4(4):465–8.PubMed
102.
Chheng K, Carter MJ, Emary K, Chanpheaktra N, Moore CE, Stoesser N, et al. A prospective study of the causes of febrile illness requiring hospitalization in children in Cambodia. PLoS One. 2013;8(4), e60634.PubMedPubMedCentral
103.
Fiestas Solórzano V, Sihuincha Maldonado M, Donaires Toscano F. Características clínicas de pacientes internados en el Hospital de Apoyo de Iquitos“ César Garayar García” durante la epidemia de dengue, enero-febrero de 2011. Rev Peru Med Exp Salud Publica. 2011;28(1):78–82.PubMed
104.
Phelan JC, Link BG, Tehranifar P. Social conditions as fundamental causes of health inequalities: theory, evidence, and policy implications. J Health Soc Behav. 2010;51(1 suppl):S28–40.PubMed
105.
Pudrovska T. Early-life socioeconomic status and mortality at three life course stages: an increasing within-cohort inequality. J Health Soc Behav. 2014;55(2):181–95.PubMed
106.
Azoh Barry J. Social sciences research on infectious diseases of poverty: too little and too late? PLoS Negl Trop Dis. 2014;8(6), e2803.PubMedPubMedCentral
107.
Halstead SB. Dengue in the Americas and Southeast Asia: do they differ? Rev Panam Salud Publica. 2006;20(6):407–15.PubMed
108.
Amarasinghe A, Kuritsky J, Letson G, Margolis H. Dengue virus infection in Africa. Emerg Infect Dis. 2011;17(8):1349–54.PubMedPubMedCentral
109.
Blanton RE, Silva LK, Morato VG, Parrado AR, Dias JP, Melo PRS, et al. Genetic ancestry and income are associated with dengue hemorrhagic fever in a highly admixed population. Eur J Hum Genet. 2008;16(6):762–5.PubMed
110.
Guzman MG, Kouri G. Dengue and dengue hemorrhagic fever in the Americas: lessons and challenges. J Clin Virol. 2003;27(1):1–13.PubMed
111.
Restrepo BN, Arboleda M, Ramírez R, Alvarez G. Actividad sérica de la acetilhidrolasa del factor activador de plaquetas en pacientes afrodescendientes y mestizos con dengue, Colombia. Biomedica. 2011;31:4.
112.
Sierra BC, Kourí G, Guzmán MG. Race: a risk factor for dengue hemorrhagic fever. Arch Virol. 2007;152(3):533–42.
113.
Halstead S. Pathogenesis of dengue: challenges to molecular biology. Science. 1988;239(4839):476–81.PubMed
114.
Arauz MJ, Ridde V, Hernández LM, Charris Y, Carabali M, Villar LÁ. Developing a social autopsy tool for dengue mortality: a pilot study. PLoS One. 2015;10(2), e0117455.PubMedPubMedCentral
Metadata
Title
Why are people with dengue dying? A scoping review of determinants for dengue mortality
Authors
Mabel Carabali
Libia Milena Hernandez
Maria Jose Arauz
Luis Angel Villar
Valéry Ridde
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Infectious Diseases / Issue 1/2015
Electronic ISSN: 1471-2334
DOI
https://doi.org/10.1186/s12879-015-1058-x

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Research article

Rifampin resistance and diabetes mellitus in a cross-sectional study of adult patients in rural South India

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Non-tuberculous mycobacteria (NTM) in Zambia: prevalence, clinical, radiological and microbiological characteristics

Research article

Clinicopathologic study of intestinal spirochetosis in Japan with special reference to human immunodeficiency virus infection status and species types: analysis of 5265 consecutive colorectal biopsies

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Assessing the use of hospital staff influenza-like absence (ILA) for enhancing hospital preparedness and national surveillance

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The variations of IL-23R are associated with susceptibility and severe clinical forms of pulmonary tuberculosis in Chinese Uygurs

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Burden of bacterial resistance among neonatal infections in low income countries: how convincing is the epidemiological evidence?
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

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Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
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Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

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A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

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