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Japanese Journal of Radiology
Published in: Japanese Journal of Radiology 10/2017

01-10-2017 | Original Article

Whole-tumor histogram analysis of the cerebral blood volume map: tumor volume defined by 11C-methionine positron emission tomography image improves the diagnostic accuracy of cerebral glioma grading

Authors: Rongli Wu, Yoshiyuki Watanabe, Atsuko Arisawa, Hiroto Takahashi, Hisashi Tanaka, Yasunori Fujimoto, Tadashi Watabe, Kayako Isohashi, Jun Hatazawa, Noriyuki Tomiyama

Published in: Japanese Journal of Radiology | Issue 10/2017

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Abstract

Purpose

This study aimed to compare the tumor volume definition using conventional magnetic resonance (MR) and 11C-methionine positron emission tomography (MET/PET) images in the differentiation of the pre-operative glioma grade by using whole-tumor histogram analysis of normalized cerebral blood volume (nCBV) maps.

Materials and methods

Thirty-four patients with histopathologically proven primary brain low-grade gliomas (n = 15) and high-grade gliomas (n = 19) underwent pre-operative or pre-biopsy MET/PET, fluid-attenuated inversion recovery, dynamic susceptibility contrast perfusion-weighted magnetic resonance imaging, and contrast-enhanced T1-weighted at 3.0 T. The histogram distribution derived from the nCBV maps was obtained by co-registering the whole tumor volume delineated on conventional MR or MET/PET images, and eight histogram parameters were assessed.

Results

The mean nCBV value had the highest AUC value (0.906) based on MET/PET images. Diagnostic accuracy significantly improved when the tumor volume was measured from MET/PET images compared with conventional MR images for the parameters of mean, 50th, and 75th percentile nCBV value (p = 0.0246, 0.0223, and 0.0150, respectively).

Conclusion

Whole-tumor histogram analysis of CBV map provides more valuable histogram parameters and increases diagnostic accuracy in the differentiation of pre-operative cerebral gliomas when the tumor volume is derived from MET/PET images.
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Metadata
Title
Whole-tumor histogram analysis of the cerebral blood volume map: tumor volume defined by 11C-methionine positron emission tomography image improves the diagnostic accuracy of cerebral glioma grading
Authors
Rongli Wu
Yoshiyuki Watanabe
Atsuko Arisawa
Hiroto Takahashi
Hisashi Tanaka
Yasunori Fujimoto
Tadashi Watabe
Kayako Isohashi
Jun Hatazawa
Noriyuki Tomiyama
Publication date
01-10-2017
Publisher
Springer Japan
Published in
Japanese Journal of Radiology / Issue 10/2017
Print ISSN: 1867-1071
Electronic ISSN: 1867-108X
DOI
https://doi.org/10.1007/s11604-017-0675-2

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