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European Radiology
Published in: European Radiology 9/2016

01-09-2016 | Neuro

Whole brain functional connectivity in clinically isolated syndrome without conventional brain MRI lesions

Authors: Yaou Liu, Zhengjia Dai, Yunyun Duan, Jing Huang, Zhuoqiong Ren, Zheng Liu, Huiqing Dong, Ni Shu, Hugo Vrenken, Mike P. Wattjes, Frederik Barkhof, Yong He, Kuncheng Li

Published in: European Radiology | Issue 9/2016

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Abstract

Objective

To investigate brain functional connectivity (FC) alterations in patients with clinically isolated syndromes (CIS) presenting without conventional brain MRI lesions, and to identify the FC differences between the CIS patients who converted to multiple sclerosis (MS) and those not converted during a 5-year follow-up.

Methods

We recruited 20 CIS patients without conventional brain lesions, 28 patients with MS and 28 healthy controls (HC). Normalized voxel-based functional connectivity strength (nFCS) was determined using resting-state fMRI (R-fMRI) and compared among groups. Furthermore, 5-years clinical follow-up of the CIS patients was performed to examine the differences in nFCS between converters and non-converters.

Results

Compared to HC, CIS patients showed significantly decreased nFCS in the visual areas and increased nFCS in several brain regions predominately in the temporal lobes. MS patients revealed more widespread higher nFCS especially in deep grey matter (DGM), compared to CIS and HC. In the four CIS patients converting to MS, significantly higher nFCS was found in right anterior cingulate gyrus (ACC) and fusiform gyrus (FG), compared to non-converted patients.

Conclusion

We demonstrated both functional impairment and compensation in CIS by R-fMRI. nFCS alteration in ACC and FG seems to occur in CIS patients at risk of developing MS.

Key Points

• Both functional impairment and compensation occur in CIS without conventional brain lesions.
• MS patients revealed more widespread higher nFCS especially in deep grey matter.
• nFCS alteration may help stratifying CIS at risk of developing MS.
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Metadata
Title
Whole brain functional connectivity in clinically isolated syndrome without conventional brain MRI lesions
Authors
Yaou Liu
Zhengjia Dai
Yunyun Duan
Jing Huang
Zhuoqiong Ren
Zheng Liu
Huiqing Dong
Ni Shu
Hugo Vrenken
Mike P. Wattjes
Frederik Barkhof
Yong He
Kuncheng Li
Publication date
01-09-2016
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 9/2016
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-015-4147-8

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