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Journal of Nuclear Cardiology
Published in: Journal of Nuclear Cardiology 1/2018

01-02-2018 | WHAT IS THIS IMAGE?

What is this image? 2017: Image 4 result

Improvement of ischemia with statin therapy

Author: Ronald G. Schwartz, MD, MS

Published in: Journal of Nuclear Cardiology | Issue 1/2018

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Excerpt

The patient in Figure 1 has a history of recently diagnosed coronary artery disease. Which description of the following list best characterizes the changes in the stress radionuclide SPECT myocardial perfusion defect scores documented at 6 weeks and 6 months following the baseline scan?
(a)
Rapid healing of myocardial infarction associated with neovascularization.
 
(b)
Improved stress perfusion following bypass graft surgery.
 
(c)
Reduction of infarction size with urgent PCI.
 
(d)
Therapeutic reduction of stress-induced perfusion abnormalities are associated with statin therapy best visualized by SPECT or PET MPI.
 
(e)
Improvement of myocardial perfusion with medication is documented and can also be observed with stress echocardiography.
 
Answer:
(d)
Therapeutic reduction of stress-induced perfusion abnormalities are associated with statin therapy best visualized by SPECT or PET MPI.
 
…
Literature
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Schwartz RG, Pearson TA, Kalaria VG Mackin ML, Williford DJ, Awasthi A, Shah A. Prospective serial evaluation of myocardial perfusion and lipids during the first six months of pravastatin therapy: Coronary artery disease regression single photon emission computed tomography monitoring trial. J Am Coll Cardiol 2003;42:600-10. (Accompanying editorial: Blumenthal RS, Gluckman TJ. New insights into the relationship between myocardial perfusion and lipid-lowering. J Am Coll Cardiol 2003;42:611-13).
2.
Schwartz RG, Pearson TA. Can single photon emission computed tomography myocardial perfusion imaging monitor the potential benefit of aggressive treatment of hyperlipidemia? (editorial point of view). J Nucl Cardiol 1997;4:555-68.CrossRefPubMed
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Schwartz RG, Kudes M. Monitoring effectiveness of medical therapy in 2006. J Nucl Cardiol 2006;13(2):184-90.CrossRefPubMed
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Shaw LJ, Berman DS, Maron DJ, et al. Optimal medical therapy with or without percutaneous coronary intervention to reduce ischemic burden results from the clinical outcomes utilizing revascularization and aggressive drug evaluation (COURAGE) trial nuclear substudy. Circulation 2008;117:1283-91.CrossRefPubMed
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Huggins GS, Pasternak RC, Alpert NM, et al. Effects of short-term treatment of hyperlipidemia on coronary vasodilator function and myocardial perfusion in regions having substantial impairment of baseline dilator reverse. Circulation 1998;98:1291-6.CrossRefPubMed
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Gould KL, Ornish D, Scherwitz L, et al. Changes in myocardial perfusion abnormalities by positron emission tomography after longterm, intense risk factor modification. JAMA 1995;274:894-901.CrossRefPubMed
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Gould KL, Martucci JP, Goldberg DI, et al. Short-term cholesterol lowering decreases size and severity of perfusion abnormalities by positron emission tomography after dipyridamole in patients with coronary artery disease. A potential noninvasive marker of healing coronary endothelium. Circulation 1994;89:1530-8.CrossRefPubMed
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Treasure CB, Klein JL, Weintraub WS, et al. Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease. N Engl J Med 1995;332:481-7.CrossRefPubMed
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Brown BG, Zhao XQ, Chait A, Fisher LD, Cheung MC, Morse JS, Dowdy AA, Marino EK, Bolson EL, Alaupovic P, Frohlich J, Albers JJ. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001;345(22):1583-92.CrossRefPubMed
Metadata
Title
What is this image? 2017: Image 4 result
Improvement of ischemia with statin therapy
Author
Ronald G. Schwartz, MD, MS
Publication date
01-02-2018
Publisher
Springer US
Published in
Journal of Nuclear Cardiology / Issue 1/2018
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI
https://doi.org/10.1007/s12350-017-1143-1

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