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Published in: Current Treatment Options in Gastroenterology 4/2018

01-12-2018 | Endoscopy (P Siersema, Section Editor)

What Is the Best Endoscopic Strategy in Acute Non-variceal Gastrointestinal Bleeding?

Authors: Livio Cipolletta, MD, Fabio Cipolletta, MD, Antonino Granata, MD, Dario Ligresti, MD, Luca Barresi, MD, Ilaria Tarantino, MD, Mario Traina, MD

Published in: Current Treatment Options in Gastroenterology | Issue 4/2018

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Opinion statement

Purpose of review

Upper non-variceal gastrointestinal bleeding (UNVGIB) remains an important clinical challenge for endoscopists, requiring skill and expertise for correct management. In this paper, we suggest the best strategy for an effective treatment of this complex category of patients.

Recent findings

Early endoscopic examination, the increasingly widespread use of endoscopic hemostasis methods, and the most powerful antisecretory agents that induce clot stabilization have radically modified the clinical scenario for treating this pathology. While hospitalization for digestive hemorrhage is decreasing, the incidence of bleeding seems to be increasing, especially in the elderly for whom a greater use of gastrolesive drugs and the presence of comorbidities are more common.

Summary

A multidisciplinary approach for initial patient evaluation and hemodynamic resuscitation prior to endoscopic treatment is crucial for correct management, prevention of rebleeding, and reduction of morbidity and mortality rates and hospital stays. Appropriate operator technical expertise, together with the availability of a wide range of endoscopes and devices, is mandatory. Newer endoscopic techniques may improve patient outcomes for difficult-to-treat lesions. Today, endoscopic hemostasis can be achieved in over 95% of patients.
Literature
1.
go back to reference Bardou M, Benhaberou-Brun D, Le Ray I, Barkun AN. Diagnosis and management of nonvariceal upper gastrointestinal bleeding. Nat Rev Gastroenterol Hepatol. 2012;9(2):97–104.CrossRef Bardou M, Benhaberou-Brun D, Le Ray I, Barkun AN. Diagnosis and management of nonvariceal upper gastrointestinal bleeding. Nat Rev Gastroenterol Hepatol. 2012;9(2):97–104.CrossRef
2.
go back to reference Marmo R, Del Piano M, Rotondano G, Koch M, Bianco MA, Zambelli A, et al. Mortality from nonulcer bleeding is similar to that of ulcer bleeding in high-risk patients with nonvariceal hemorrhage: a prospective database study in Italy. Gastrointest Endosc. 2012;75(2):263–72. 72.e1CrossRef Marmo R, Del Piano M, Rotondano G, Koch M, Bianco MA, Zambelli A, et al. Mortality from nonulcer bleeding is similar to that of ulcer bleeding in high-risk patients with nonvariceal hemorrhage: a prospective database study in Italy. Gastrointest Endosc. 2012;75(2):263–72. 72.e1CrossRef
3.
go back to reference Hearnshaw SA, Logan RF, Lowe D, Travis SP, Murphy MF, Palmer KR. Acute upper gastrointestinal bleeding in the UK: patient characteristics, diagnoses and outcomes in the 2007 UK audit. Gut. 2011;60(10):1327–35.CrossRef Hearnshaw SA, Logan RF, Lowe D, Travis SP, Murphy MF, Palmer KR. Acute upper gastrointestinal bleeding in the UK: patient characteristics, diagnoses and outcomes in the 2007 UK audit. Gut. 2011;60(10):1327–35.CrossRef
4.
go back to reference Gralnek IM, Dumonceau JM, Kuipers EJ, Lanas A, Sanders DS, Kurien M, et al. Diagnosis and management of nonvariceal upper gastrointestinal hemorrhage: European Society of Gastrointestinal Endoscopy (ESGE) Guideline. Endoscopy. 2015;47(10):a1–46.CrossRef Gralnek IM, Dumonceau JM, Kuipers EJ, Lanas A, Sanders DS, Kurien M, et al. Diagnosis and management of nonvariceal upper gastrointestinal hemorrhage: European Society of Gastrointestinal Endoscopy (ESGE) Guideline. Endoscopy. 2015;47(10):a1–46.CrossRef
5.
go back to reference •• Leontiadis GI, Molloy-Bland M, Moayyedi P, Howden CW. Effect of comorbidity on mortality in patients with peptic ulcer bleeding: systematic review and meta-analysis. Am J Gastroenterol. 2013;108(3):331–45. Systematic review and meta-analysis strongly emphasize the role of correct comorbidities management to improve the outcome in patients with UNVGIB.CrossRef •• Leontiadis GI, Molloy-Bland M, Moayyedi P, Howden CW. Effect of comorbidity on mortality in patients with peptic ulcer bleeding: systematic review and meta-analysis. Am J Gastroenterol. 2013;108(3):331–45. Systematic review and meta-analysis strongly emphasize the role of correct comorbidities management to improve the outcome in patients with UNVGIB.CrossRef
6.
go back to reference Marmo R, Koch M, Cipolletta L, Capurso L, Pera A, Bianco MA, et al. Predictive factors of mortality from nonvariceal upper gastrointestinal hemorrhage: a multicenter study. Am J Gastroenterol. 2008;103(7):1639–47.CrossRef Marmo R, Koch M, Cipolletta L, Capurso L, Pera A, Bianco MA, et al. Predictive factors of mortality from nonvariceal upper gastrointestinal hemorrhage: a multicenter study. Am J Gastroenterol. 2008;103(7):1639–47.CrossRef
7.
go back to reference Rockall TA, Logan RF, Devlin HB, Northfield TC. Risk assessment after acute upper gastrointestinal haemorrhage. Gut. 1996;38(3):316–21.CrossRef Rockall TA, Logan RF, Devlin HB, Northfield TC. Risk assessment after acute upper gastrointestinal haemorrhage. Gut. 1996;38(3):316–21.CrossRef
8.
go back to reference Blatchford O, Murray WR, Blatchford M. A risk score to predict need for treatment for upper-gastrointestinal haemorrhage. Lancet. 2000;356(9238):1318–21.CrossRef Blatchford O, Murray WR, Blatchford M. A risk score to predict need for treatment for upper-gastrointestinal haemorrhage. Lancet. 2000;356(9238):1318–21.CrossRef
9.
go back to reference de Groot NL, Bosman JH, Siersema PD, van Oijen MG. Prediction scores in gastrointestinal bleeding: a systematic review and quantitative appraisal. Endoscopy. 2012;44(8):731–9.CrossRef de Groot NL, Bosman JH, Siersema PD, van Oijen MG. Prediction scores in gastrointestinal bleeding: a systematic review and quantitative appraisal. Endoscopy. 2012;44(8):731–9.CrossRef
10.
go back to reference Hébert PC, Wells G, Blajchman MA, Marshall J, Martin C, Pagliarello G, et al. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med. 1999;340(6):409–17.CrossRef Hébert PC, Wells G, Blajchman MA, Marshall J, Martin C, Pagliarello G, et al. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med. 1999;340(6):409–17.CrossRef
11.
go back to reference Baradarian R, Ramdhaney S, Chapalamadugu R, Skoczylas L, Wang K, Rivilis S, et al. Early intensive resuscitation of patients with upper gastrointestinal bleeding decreases mortality. Am J Gastroenterol. 2004;99(4):619–22.CrossRef Baradarian R, Ramdhaney S, Chapalamadugu R, Skoczylas L, Wang K, Rivilis S, et al. Early intensive resuscitation of patients with upper gastrointestinal bleeding decreases mortality. Am J Gastroenterol. 2004;99(4):619–22.CrossRef
12.
go back to reference Sung JJ, Tsoi KK, Ma TK, Yung MY, Lau JY, Chiu PW. Causes of mortality in patients with peptic ulcer bleeding: a prospective cohort study of 10,428 cases. Am J Gastroenterol. 2010;105(1):84–9.CrossRef Sung JJ, Tsoi KK, Ma TK, Yung MY, Lau JY, Chiu PW. Causes of mortality in patients with peptic ulcer bleeding: a prospective cohort study of 10,428 cases. Am J Gastroenterol. 2010;105(1):84–9.CrossRef
13.
go back to reference Sreedharan A, Martin J, Leontiadis GI, Dorward S, Howden CW, Forman D, et al. Proton pump inhibitor treatment initiated prior to endoscopic diagnosis in upper gastrointestinal bleeding. Cochrane Database Syst Rev. 2010;7:CD005415. Sreedharan A, Martin J, Leontiadis GI, Dorward S, Howden CW, Forman D, et al. Proton pump inhibitor treatment initiated prior to endoscopic diagnosis in upper gastrointestinal bleeding. Cochrane Database Syst Rev. 2010;7:CD005415.
14.
go back to reference Theivanayagam S, Lim RG, Cobell WJ, Gowda JT, Matteson ML, Choudhary A, et al. Administration of erythromycin before endoscopy in upper gastrointestinal bleeding: a meta-analysis of randomized controlled trials. Saudi J Gastroenterol. 2013;19(5):205–10.CrossRef Theivanayagam S, Lim RG, Cobell WJ, Gowda JT, Matteson ML, Choudhary A, et al. Administration of erythromycin before endoscopy in upper gastrointestinal bleeding: a meta-analysis of randomized controlled trials. Saudi J Gastroenterol. 2013;19(5):205–10.CrossRef
15.
go back to reference Barkun AN, Bardou M, Martel M, Gralnek IM, Sung JJ. Prokinetics in acute upper GI bleeding: a meta-analysis. Gastrointest Endosc. 2010;72(6):1138–45.CrossRef Barkun AN, Bardou M, Martel M, Gralnek IM, Sung JJ. Prokinetics in acute upper GI bleeding: a meta-analysis. Gastrointest Endosc. 2010;72(6):1138–45.CrossRef
16.
go back to reference Altraif I, Handoo FA, Aljumah A, Alalwan A, Dafalla M, Saeed AM, et al. Effect of erythromycin before endoscopy in patients presenting with variceal bleeding: a prospective, randomized, double-blind, placebo-controlled trial. Gastrointest Endosc. 2011;73(2):245–50.CrossRef Altraif I, Handoo FA, Aljumah A, Alalwan A, Dafalla M, Saeed AM, et al. Effect of erythromycin before endoscopy in patients presenting with variceal bleeding: a prospective, randomized, double-blind, placebo-controlled trial. Gastrointest Endosc. 2011;73(2):245–50.CrossRef
17.
go back to reference Laine L, McQuaid KR. Endoscopic therapy for bleeding ulcers: an evidence-based approach based on meta-analyses of randomized controlled trials. Clin Gastroenterol Hepatol. 2009;7(1):33–47.CrossRef Laine L, McQuaid KR. Endoscopic therapy for bleeding ulcers: an evidence-based approach based on meta-analyses of randomized controlled trials. Clin Gastroenterol Hepatol. 2009;7(1):33–47.CrossRef
18.
go back to reference Barkun AN, Martel M, Toubouti Y, Rahme E, Bardou M. Endoscopic hemostasis in peptic ulcer bleeding for patients with high-risk lesions: a series of meta-analyses. Gastrointest Endosc. 2009;69(4):786–99.CrossRef Barkun AN, Martel M, Toubouti Y, Rahme E, Bardou M. Endoscopic hemostasis in peptic ulcer bleeding for patients with high-risk lesions: a series of meta-analyses. Gastrointest Endosc. 2009;69(4):786–99.CrossRef
19.
go back to reference Church NI, Palmer KR. Injection therapy for endoscopic haemostasis. Baillieres Best Pract Res Clin Gastroenterol. 2000;14(3):427–41.CrossRef Church NI, Palmer KR. Injection therapy for endoscopic haemostasis. Baillieres Best Pract Res Clin Gastroenterol. 2000;14(3):427–41.CrossRef
20.
go back to reference Lau JY, Leung JW. Injection therapy for bleeding peptic ulcers. Gastrointest Endosc Clin N Am. 1997;7(4):575–91.CrossRef Lau JY, Leung JW. Injection therapy for bleeding peptic ulcers. Gastrointest Endosc Clin N Am. 1997;7(4):575–91.CrossRef
21.
go back to reference Marmo R, Rotondano G, Piscopo R, Bianco MA, D’Angella R, Cipolletta L. Dual therapy versus monotherapy in the endoscopic treatment of high-risk bleeding ulcers: a meta-analysis of controlled trials. Am J Gastroenterol. 2007;102(2):279–89.CrossRef Marmo R, Rotondano G, Piscopo R, Bianco MA, D’Angella R, Cipolletta L. Dual therapy versus monotherapy in the endoscopic treatment of high-risk bleeding ulcers: a meta-analysis of controlled trials. Am J Gastroenterol. 2007;102(2):279–89.CrossRef
22.
go back to reference Savides TJ, Jensen DM. Therapeutic endoscopy for nonvariceal gastrointestinal bleeding. Gastroenterol Clin N Am. 2000;29(2):465–87.CrossRef Savides TJ, Jensen DM. Therapeutic endoscopy for nonvariceal gastrointestinal bleeding. Gastroenterol Clin N Am. 2000;29(2):465–87.CrossRef
23.
go back to reference Liu JJ, Saltzman JR. Endoscopic hemostasis treatment: how should you perform it? Can J Gastroenterol. 2009;23(7):481–3.CrossRef Liu JJ, Saltzman JR. Endoscopic hemostasis treatment: how should you perform it? Can J Gastroenterol. 2009;23(7):481–3.CrossRef
24.
go back to reference Barkun AN, Bardou M, Kuipers EJ, Sung J, Hunt RH, Martel M, et al. International consensus recommendations on the management of patients with nonvariceal upper gastrointestinal bleeding. Ann Intern Med. 2010;152(2):101–13.CrossRef Barkun AN, Bardou M, Kuipers EJ, Sung J, Hunt RH, Martel M, et al. International consensus recommendations on the management of patients with nonvariceal upper gastrointestinal bleeding. Ann Intern Med. 2010;152(2):101–13.CrossRef
25.
go back to reference Vergara M, Bennett C, Calvet X, Gisbert JP. Epinephrine injection versus epinephrine injection and a second endoscopic method in high-risk bleeding ulcers. Cochrane Database Syst Rev. 2014;10:CD005584. Vergara M, Bennett C, Calvet X, Gisbert JP. Epinephrine injection versus epinephrine injection and a second endoscopic method in high-risk bleeding ulcers. Cochrane Database Syst Rev. 2014;10:CD005584.
26.
go back to reference Walia SS, Sachdeva A, Kim JJ, Portocarrero DJ, Lewis TD, Zhao YS. Cyanoacrylate spray for treatment of difficult-to-control GI bleeding. Gastrointest Endosc. 2013;78(3):536–9.CrossRef Walia SS, Sachdeva A, Kim JJ, Portocarrero DJ, Lewis TD, Zhao YS. Cyanoacrylate spray for treatment of difficult-to-control GI bleeding. Gastrointest Endosc. 2013;78(3):536–9.CrossRef
27.
go back to reference D’Imperio N, Papadia C, Baroncini D, Piemontese A, Billi P, Dal Monte PP. N-butyl-2-cyanoacrylate in the endoscopic treatment of Dieulafoy ulcer. Endoscopy. 1995;27(2):216.CrossRef D’Imperio N, Papadia C, Baroncini D, Piemontese A, Billi P, Dal Monte PP. N-butyl-2-cyanoacrylate in the endoscopic treatment of Dieulafoy ulcer. Endoscopy. 1995;27(2):216.CrossRef
28.
go back to reference Bianco MA, Rotondano G, Marmo R, Piscopo R, Orsini L, Cipolletta L. Combined epinephrine and bipolar probe coagulation vs. bipolar probe coagulation alone for bleeding peptic ulcer: a randomized, controlled trial. Gastrointest Endosc. 2004;60(6):910–5.CrossRef Bianco MA, Rotondano G, Marmo R, Piscopo R, Orsini L, Cipolletta L. Combined epinephrine and bipolar probe coagulation vs. bipolar probe coagulation alone for bleeding peptic ulcer: a randomized, controlled trial. Gastrointest Endosc. 2004;60(6):910–5.CrossRef
29.
go back to reference Chau CH, Siu WT, Law BK, Tang CN, Kwok SY, Luk YW, et al. Randomized controlled trial comparing epinephrine injection plus heat probe coagulation versus epinephrine injection plus argon plasma coagulation for bleeding peptic ulcers. Gastrointest Endosc. 2003;57(4):455–61.CrossRef Chau CH, Siu WT, Law BK, Tang CN, Kwok SY, Luk YW, et al. Randomized controlled trial comparing epinephrine injection plus heat probe coagulation versus epinephrine injection plus argon plasma coagulation for bleeding peptic ulcers. Gastrointest Endosc. 2003;57(4):455–61.CrossRef
30.
go back to reference Wang HM, Hsu PI, Lo GH, Chen TA, Cheng LC, Chen WC, et al. Comparison of hemostatic efficacy for argon plasma coagulation and distilled water injection in treating high-risk bleeding ulcers. J Clin Gastroenterol. 2009;43(10):941–5.CrossRef Wang HM, Hsu PI, Lo GH, Chen TA, Cheng LC, Chen WC, et al. Comparison of hemostatic efficacy for argon plasma coagulation and distilled water injection in treating high-risk bleeding ulcers. J Clin Gastroenterol. 2009;43(10):941–5.CrossRef
31.
go back to reference Cipolletta L, Bianco MA, Rotondano G, Piscopo R, Prisco A, Garofano ML. Prospective comparison of argon plasma coagulator and heater probe in the endoscopic treatment of major peptic ulcer bleeding. Gastrointest Endosc. 1998;48(2):191–5.CrossRef Cipolletta L, Bianco MA, Rotondano G, Piscopo R, Prisco A, Garofano ML. Prospective comparison of argon plasma coagulator and heater probe in the endoscopic treatment of major peptic ulcer bleeding. Gastrointest Endosc. 1998;48(2):191–5.CrossRef
32.
go back to reference Kirschniak A, Kratt T, Stüker D, Braun A, Schurr MO, Königsrainer A. A new endoscopic over-the-scope clip system for treatment of lesions and bleeding in the GI tract: first clinical experiences. Gastrointest Endosc. 2007;66(1):162–7.CrossRef Kirschniak A, Kratt T, Stüker D, Braun A, Schurr MO, Königsrainer A. A new endoscopic over-the-scope clip system for treatment of lesions and bleeding in the GI tract: first clinical experiences. Gastrointest Endosc. 2007;66(1):162–7.CrossRef
33.
go back to reference Chan SM, Chiu PW, Teoh AY, Lau JY. Use of the over-the-scope clip for treatment of refractory upper gastrointestinal bleeding: a case series. Endoscopy 2014;46(5):428–431.CrossRef Chan SM, Chiu PW, Teoh AY, Lau JY. Use of the over-the-scope clip for treatment of refractory upper gastrointestinal bleeding: a case series. Endoscopy 2014;46(5):428–431.CrossRef
34.
go back to reference Manta R, Galloro G, Mangiavillano B, Conigliaro R, Pasquale L, Arezzo A, et al. Over-the-scope clip (OTSC) represents an effective endoscopic treatment for acute GI bleeding after failure of conventional techniques. Surg Endosc. 2013;27(9):3162–4.CrossRef Manta R, Galloro G, Mangiavillano B, Conigliaro R, Pasquale L, Arezzo A, et al. Over-the-scope clip (OTSC) represents an effective endoscopic treatment for acute GI bleeding after failure of conventional techniques. Surg Endosc. 2013;27(9):3162–4.CrossRef
35.
go back to reference Repici A, Arezzo A, De Caro G, Morino M, Pagano N, Rando G, et al. Clinical experience with a new endoscopic over-the-scope clip system for use in the GI tract. Dig Liver Dis. 2009;41(6):406–10.CrossRef Repici A, Arezzo A, De Caro G, Morino M, Pagano N, Rando G, et al. Clinical experience with a new endoscopic over-the-scope clip system for use in the GI tract. Dig Liver Dis. 2009;41(6):406–10.CrossRef
36.
go back to reference Kirschniak A, Subotova N, Zieker D, Königsrainer A, Kratt T. The over-the-scope clip (OTSC) for the treatment of gastrointestinal bleeding, perforations, and fistulas. Surg Endosc. 2011;25(9):2901–5.CrossRef Kirschniak A, Subotova N, Zieker D, Königsrainer A, Kratt T. The over-the-scope clip (OTSC) for the treatment of gastrointestinal bleeding, perforations, and fistulas. Surg Endosc. 2011;25(9):2901–5.CrossRef
37.
go back to reference Holster IL, van Beusekom HM, Kuipers EJ, Leebeek FW, de Maat MP, Tjwa ET. Effects of a hemostatic powder hemospray on coagulation and clot formation. Endoscopy. 2015;47(7):638–45.CrossRef Holster IL, van Beusekom HM, Kuipers EJ, Leebeek FW, de Maat MP, Tjwa ET. Effects of a hemostatic powder hemospray on coagulation and clot formation. Endoscopy. 2015;47(7):638–45.CrossRef
38.
go back to reference • Sung JJ, Luo D, Wu JC, Ching JY, Chan FK, Lau JY, et al. Early clinical experience of the safety and effectiveness of Hemospray in achieving hemostasis in patients with acute peptic ulcer bleeding. Endoscopy. 2011;43(4):291–5. Pilot study firstly described safety and effectiveness, in humans, of hemostatic procedure easy to apply endoscopically in challenging situations.CrossRef • Sung JJ, Luo D, Wu JC, Ching JY, Chan FK, Lau JY, et al. Early clinical experience of the safety and effectiveness of Hemospray in achieving hemostasis in patients with acute peptic ulcer bleeding. Endoscopy. 2011;43(4):291–5. Pilot study firstly described safety and effectiveness, in humans, of hemostatic procedure easy to apply endoscopically in challenging situations.CrossRef
39.
go back to reference Granata A, Ligresti D, Curcio G, Barresi L, Tarantino I, Orlando R, et al. Hemospray rescue treatment of gastroenteric anastomotic bleeding. Endoscopy. 2015;47:E327–E8.CrossRef Granata A, Ligresti D, Curcio G, Barresi L, Tarantino I, Orlando R, et al. Hemospray rescue treatment of gastroenteric anastomotic bleeding. Endoscopy. 2015;47:E327–E8.CrossRef
40.
go back to reference Granata A, Curcio G, Barresi L, Ligresti D, Tarantino I, Orlando R, et al. Hemospray rescue treatment of severe refractory bleeding associated with ischemic colitis: a case series. Int J Color Dis. 2016;31(3):719–20.CrossRef Granata A, Curcio G, Barresi L, Ligresti D, Tarantino I, Orlando R, et al. Hemospray rescue treatment of severe refractory bleeding associated with ischemic colitis: a case series. Int J Color Dis. 2016;31(3):719–20.CrossRef
41.
go back to reference Arena M, Masci E, Eusebi LH, Iabichino G, Mangiavillano B, Viaggi P, et al. Hemospray for treatment of acute bleeding due to upper gastrointestinal tumours. Dig Liver Dis. 2017;49(5):514–7.CrossRef Arena M, Masci E, Eusebi LH, Iabichino G, Mangiavillano B, Viaggi P, et al. Hemospray for treatment of acute bleeding due to upper gastrointestinal tumours. Dig Liver Dis. 2017;49(5):514–7.CrossRef
42.
go back to reference Smith LA, Stanley AJ, Bergman JJ, Kiesslich R, Hoffman A, Tjwa ET, et al. Hemospray application in nonvariceal upper gastrointestinal bleeding: results of the Survey to Evaluate the Application of Hemospray in the Luminal Tract. J Clin Gastroenterol. 2014;48(10):e89–92.PubMed Smith LA, Stanley AJ, Bergman JJ, Kiesslich R, Hoffman A, Tjwa ET, et al. Hemospray application in nonvariceal upper gastrointestinal bleeding: results of the Survey to Evaluate the Application of Hemospray in the Luminal Tract. J Clin Gastroenterol. 2014;48(10):e89–92.PubMed
43.
go back to reference Chen YI, Barkun AN, Soulellis C, Mayrand S, Ghali P. Use of the endoscopically applied hemostatic powder TC-325 in cancer-related upper GI hemorrhage: preliminary experience (with video). Gastrointest Endosc. 2012;75(6):1278–81.CrossRef Chen YI, Barkun AN, Soulellis C, Mayrand S, Ghali P. Use of the endoscopically applied hemostatic powder TC-325 in cancer-related upper GI hemorrhage: preliminary experience (with video). Gastrointest Endosc. 2012;75(6):1278–81.CrossRef
44.
go back to reference Yau AH, Ou G, Galorport C, Amar J, Bressler B, Donnellan F, et al. Safety and efficacy of Hemospray® in upper gastrointestinal bleeding. Can J Gastroenterol Hepatol. 2014;28(2):72–6.CrossRef Yau AH, Ou G, Galorport C, Amar J, Bressler B, Donnellan F, et al. Safety and efficacy of Hemospray® in upper gastrointestinal bleeding. Can J Gastroenterol Hepatol. 2014;28(2):72–6.CrossRef
45.
go back to reference Huang R, Pan Y, Hui N, Guo X, Zhang L, Wang X, et al. Polysaccharide hemostatic system for hemostasis management in colorectal endoscopic mucosal resection. Dig Endosc. 2014;26(1):63–8.CrossRef Huang R, Pan Y, Hui N, Guo X, Zhang L, Wang X, et al. Polysaccharide hemostatic system for hemostasis management in colorectal endoscopic mucosal resection. Dig Endosc. 2014;26(1):63–8.CrossRef
46.
go back to reference Park JC, Kim YJ, Kim EH, Lee J, Yang HS, Hahn KY, et al. Effectiveness of the polysaccharide hemostatic powder in non-variceal upper gastrointestinal bleeding: using propensity score matching. J Gastroenterol Hepatol. 2018; Park JC, Kim YJ, Kim EH, Lee J, Yang HS, Hahn KY, et al. Effectiveness of the polysaccharide hemostatic powder in non-variceal upper gastrointestinal bleeding: using propensity score matching. J Gastroenterol Hepatol. 2018;
47.
go back to reference Beg S, Al-Bakir I, Bhuva M, Patel J, Fullard M, Leahy A. Early clinical experience of the safety and efficacy of EndoClot in the management of non-variceal upper gastrointestinal bleeding. Endosc Int Open. 2015;3(6):E605–9.CrossRef Beg S, Al-Bakir I, Bhuva M, Patel J, Fullard M, Leahy A. Early clinical experience of the safety and efficacy of EndoClot in the management of non-variceal upper gastrointestinal bleeding. Endosc Int Open. 2015;3(6):E605–9.CrossRef
48.
go back to reference Banerjee S, Barth BA, Bhat YM, Desilets DJ, Gottlieb KT, Maple JT, et al. Endoscopic closure devices. Gastrointest Endosc. 2012;76(2):244–51.CrossRef Banerjee S, Barth BA, Bhat YM, Desilets DJ, Gottlieb KT, Maple JT, et al. Endoscopic closure devices. Gastrointest Endosc. 2012;76(2):244–51.CrossRef
49.
go back to reference Jirapinyo P, Watson RR, Thompson CC. Use of a novel endoscopic suturing device to treat recalcitrant marginal ulceration (with video). Gastrointest Endosc. 2012;76(2):435–9.CrossRef Jirapinyo P, Watson RR, Thompson CC. Use of a novel endoscopic suturing device to treat recalcitrant marginal ulceration (with video). Gastrointest Endosc. 2012;76(2):435–9.CrossRef
50.
go back to reference Chiu PW, Chan FK, Lau JY. Endoscopic suturing for ulcer exclusion in patients with massively bleeding large gastric ulcer. Gastroenterology. 2015;149(1):29–30.CrossRef Chiu PW, Chan FK, Lau JY. Endoscopic suturing for ulcer exclusion in patients with massively bleeding large gastric ulcer. Gastroenterology. 2015;149(1):29–30.CrossRef
51.
go back to reference Kantsevoy SV, Bitner M, Mitrakov AA, Thuluvath PJ. Endoscopic suturing closure of large mucosal defects after endoscopic submucosal dissection is technically feasible, fast, and eliminates the need for hospitalization (with videos). Gastrointest Endosc. 2014;79(3):503–7.CrossRef Kantsevoy SV, Bitner M, Mitrakov AA, Thuluvath PJ. Endoscopic suturing closure of large mucosal defects after endoscopic submucosal dissection is technically feasible, fast, and eliminates the need for hospitalization (with videos). Gastrointest Endosc. 2014;79(3):503–7.CrossRef
52.
go back to reference Laine L, Jensen DM. Management of patients with ulcer bleeding. Am J Gastroenterol. 2012;107(3):345–60.CrossRef Laine L, Jensen DM. Management of patients with ulcer bleeding. Am J Gastroenterol. 2012;107(3):345–60.CrossRef
53.
go back to reference Marmo R, Bucci C, Rea M, Rotondano G. Treat the patient, not just the source of bleeding. Am J Gastroenterol. 2013;108(9):1533–4.CrossRef Marmo R, Bucci C, Rea M, Rotondano G. Treat the patient, not just the source of bleeding. Am J Gastroenterol. 2013;108(9):1533–4.CrossRef
Metadata
Title
What Is the Best Endoscopic Strategy in Acute Non-variceal Gastrointestinal Bleeding?
Authors
Livio Cipolletta, MD
Fabio Cipolletta, MD
Antonino Granata, MD
Dario Ligresti, MD
Luca Barresi, MD
Ilaria Tarantino, MD
Mario Traina, MD
Publication date
01-12-2018
Publisher
Springer US
Published in
Current Treatment Options in Gastroenterology / Issue 4/2018
Print ISSN: 1092-8472
Electronic ISSN: 1534-309X
DOI
https://doi.org/10.1007/s11938-018-0192-0

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