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Current Allergy and Asthma Reports
Published in: Current Allergy and Asthma Reports 8/2016

01-08-2016 | Asthma (WJ Calhoun and V Ortega, Section Editors)

What Ancestry Can Tell Us About the Genetic Origins of Inter-Ethnic Differences in Asthma Expression

Authors: Natalia Hernandez-Pacheco, Carlos Flores, Sam S. Oh, Esteban G. Burchard, Maria Pino-Yanes

Published in: Current Allergy and Asthma Reports | Issue 8/2016

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Abstract

Differences in asthma prevalence have been described across different populations, suggesting that genetic ancestry can play an important role in this disease. In fact, several studies have demonstrated an association between African ancestry with increased asthma susceptibility and severity, higher immunoglobulin E levels, and lower lung function. In contrast, Native American ancestry has been shown to have a protective role for this disease. Genome-wide association studies have allowed the identification of population-specific genetic variants with varying allele frequency among populations. Additionally, the correlation of genetic ancestry at the chromosomal level with asthma and related traits by means of admixture mapping has revealed regions of the genome where ancestry is correlated with the disease. In this review, we discuss the evidence supporting the association of genetic ancestry with asthma susceptibility and asthma-related traits, and highlight the regions of the genome harboring ancestry-specific genetic risk factors.
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Metadata
Title
What Ancestry Can Tell Us About the Genetic Origins of Inter-Ethnic Differences in Asthma Expression
Authors
Natalia Hernandez-Pacheco
Carlos Flores
Sam S. Oh
Esteban G. Burchard
Maria Pino-Yanes
Publication date
01-08-2016
Publisher
Springer US
Published in
Current Allergy and Asthma Reports / Issue 8/2016
Print ISSN: 1529-7322
Electronic ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-016-0635-4

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