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At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
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BMC Medical Research Methodology
Published in: BMC Medical Research Methodology 1/2012

Open Access 01-12-2012 | Research article

Weight change in control group participants in behavioural weight loss interventions: a systematic review and meta-regression study

Authors: Lauren Waters, Alexis St George, Tien Chey, Adrian Bauman

Published in: BMC Medical Research Methodology | Issue 1/2012

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Abstract

Background

Unanticipated control group improvements have been observed in intervention trials targeting various health behaviours. This phenomenon has not been studied in the context of behavioural weight loss intervention trials. The purpose of this study is to conduct a systematic review and meta-regression of behavioural weight loss interventions to quantify control group weight change, and relate the size of this effect to specific trial and sample characteristics.

Methods

Database searches identified reports of intervention trials meeting the inclusion criteria. Data on control group weight change and possible explanatory factors were abstracted and analysed descriptively and quantitatively.

Results

85 trials were reviewed and 72 were included in the meta-regression. While there was no change in control group weight, control groups receiving usual care lost 1 kg more than control groups that received no intervention, beyond measurement.

Conclusions

There are several possible explanations why control group changes occur in intervention trials targeting other behaviours, but not for weight loss. Control group participation may prevent weight gain, although more research is needed to confirm this hypothesis.
Appendix
Available only for authorised users
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Metadata
Title
Weight change in control group participants in behavioural weight loss interventions: a systematic review and meta-regression study
Authors
Lauren Waters
Alexis St George
Tien Chey
Adrian Bauman
Publication date
01-12-2012
Publisher
BioMed Central
Published in
BMC Medical Research Methodology / Issue 1/2012
Electronic ISSN: 1471-2288
DOI
https://doi.org/10.1186/1471-2288-12-120

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