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01-05-2019 | Neuro

Wavelet-based reconstruction of dynamic susceptibility MR-perfusion: a new method to visualize hypervascular brain tumors

Authors: Thomas Huber, Lukas Rotkopf, Benedikt Wiestler, Wolfgang G. Kunz, Stefanie Bette, Jens Gempt, Christine Preibisch, Jens Ricke, Claus Zimmer, Jan S. Kirschke, Wieland H. Sommer, Kolja M. Thierfelder

Published in: European Radiology | Issue 5/2019

Abstract

Objectives

Parameter maps based on wavelet-transform post-processing of dynamic perfusion data offer an innovative way of visualizing blood vessels in a fully automated, user-independent way. The aims of this study were (i) a proof of concept regarding wavelet-based analysis of dynamic susceptibility contrast (DSC) MRI data and (ii) to demonstrate advantages of wavelet-based measures compared to standard cerebral blood volume (CBV) maps in patients with the initial diagnosis of glioblastoma (GBM).

Methods

Consecutive 3-T DSC MRI datasets of 46 subjects with GBM (mean age 63.0 ± 13.1 years, 28 m) were retrospectively included in this feasibility study. Vessel-specific wavelet magnetic resonance perfusion (wavelet-MRP) maps were calculated using the wavelet transform (Paul wavelet, order 1) of each voxel time course. Five different aspects of image quality and tumor delineation were each qualitatively rated on a 5-point Likert scale. Quantitative analysis included image contrast and contrast-to-noise ratio.

Results

Vessel-specific wavelet-MRP maps could be calculated within a mean time of 2:27 min. Wavelet-MRP achieved higher scores compared to CBV in all qualitative ratings: tumor depiction (4.02 vs. 2.33), contrast enhancement (3.93 vs. 2.23), central necrosis (3.86 vs. 2.40), morphologic correlation (3.87 vs. 2.24), and overall impression (4.00 vs. 2.41); all p < .001. Quantitative image analysis showed a better image contrast and higher contrast-to-noise ratios for wavelet-MRP compared to conventional perfusion maps (all p < .001).

Conclusions

wavelet-MRP is a fast and fully automated post-processing technique that yields reproducible perfusion maps with a clearer vascular depiction of GBM compared to standard CBV maps.

Key Points

• Wavelet-MRP offers high-contrast perfusion maps with a clear delineation of focal perfusion alterations.

• Both image contrast and visual image quality were beneficial for wavelet-MRP compared to standard perfusion maps like CBV.

• Wavelet-MRP can be automatically calculated from existing dynamic susceptibility contrast (DSC) perfusion data.

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Title: Wavelet-based reconstruction of dynamic susceptibility MR-perfusion: a new method to visualize hypervascular brain tumors
Authors: Thomas Huber
Lukas Rotkopf
Benedikt Wiestler
Wolfgang G. Kunz
Stefanie Bette
Jens Gempt
Christine Preibisch
Jens Ricke
Claus Zimmer
Jan S. Kirschke
Wieland H. Sommer
Kolja M. Thierfelder
Publication date: 01-05-2019
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 5/2019
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-018-5892-2

At a glance: The STEP trials

Springer Medicine

Wavelet-based reconstruction of dynamic susceptibility MR-perfusion: a new method to visualize hypervascular brain tumors

Abstract

Objectives

Methods

Results

Conclusions

Key Points

At a glance: The STEP trials

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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