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Archives of Gynecology and Obstetrics

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Open Access 01-03-2020 | Vulvar Cancer | Gynecologic Oncology

The impact of p16^ink4a positivity in invasive vulvar cancer on disease-free and disease-specific survival, a retrospective study

Authors: Lisa Gensthaler, Elmar A. Joura, Laia Alemany, Reinhard Horvat, Silvia de Sanjosé, Sophie Pils

Published in: Archives of Gynecology and Obstetrics | Issue 3/2020

Abstract

Purpose

To evaluate HPV and p16^ink4a status as prognostic factors in patients with invasive vulvar cancer.

Methods

Retrospective analysis of disease-free (DFS) and disease-specific survival (DSS) of patients with invasive vulvar cancer at a single tertiary care center. Histology, HPV and p16^ink4a status were evaluated in the context of a global multicenter trial. Logistic regression models were performed to identify the impact of p16^ink4a positivity.

Results

135 patients were included in the analysis. 32 (23.7%) showed a p16^ink4a expression of over 25%. Disease-free and disease-specific survival was longer in p16^ink4a positive patients (23 vs. 10 months, p = 0.004, respectively, 29 vs. 21 months, p = 0.016). In multivariate analysis, p16^ink4a positivity was an independent parameter for DFS (p = 0.025, HR: 2.120 (1.100–4.085)), but not for DSS (p = 0.926, HR: 1.029 (0.558–1.901), in contrast to age and tumor stage.

Conclusions

Age and tumor stage negatively affect survival. However, disease-free survival is significantly longer in patients with p16^ink4a positive invasive vulvar cancer.

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Title: The impact of p16ink4a positivity in invasive vulvar cancer on disease-free and disease-specific survival, a retrospective study
Authors: Lisa Gensthaler
Elmar A. Joura
Laia Alemany
Reinhard Horvat
Silvia de Sanjosé
Sophie Pils
Publication date: 01-03-2020
Publisher: Springer Berlin Heidelberg
Keywords: Vulvar Cancer
Vulvar Cancer
Published in: Archives of Gynecology and Obstetrics / Issue 3/2020
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-020-05431-7

At a glance: The STEP trials

Springer Medicine

The impact of p16^ink4a positivity in invasive vulvar cancer on disease-free and disease-specific survival, a retrospective study

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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