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European Journal of Nuclear Medicine and Molecular Imaging

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01-09-2021 | Vulvar Cancer | Editorial

Is it time to include [¹⁸F]FDG-PET/CT in the diagnostic work-up for lymph node staging in cN0 vulvar cancer patients?

Authors: Nicolas Aide, Stephanie Markovina, Annamaria Ferrero

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 10/2021

Excerpt

The study from Rufini et al. [1] published in this issue of the EJNMMI is the largest series of vulvar cancer patients pre-operatively staged with [¹⁸F]FDG-PET/CT. Given the scarcity of this disease and the importance of nodal staging, this study brings important insights to the nuclear medicine and oncology communities. …

Rufini V, Garganese G, Ieria FP, Pasciuto T, Fragomeni SM, Gui B, et al. Diagnostic performance of preoperative [(18)F]FDG-PET/CT for lymph node staging in vulvar cancer: a large single-centre study. Eur J Nucl Med Mol Imaging. 2021. https://doi.org/10.1007/s00259-021-05257-8.

National Comprehensive Cancer Network (NCCN) guidelines for vulvar cancer (squamous cell carcinoma) version 2.2021.

Oonk MHM, Planchamp F, Baldwin P, Bidzinski M, Brännström M, Landoni F, et al. European Society of Gynaecological Oncology guidelines for the management of patients with vulvar cancer. International Journal of Gynecological Cancer. 2017;27:832–7. https://doi.org/10.1097/igc.0000000000000975.CrossRefPubMed

ACR Appropriateness Criteria® Staging and follow-up of vulvar cancer American College of Radiology. https://acsearch.acr.org/docs/3102402/Narrative/. .

Triumbari EKA, de Koster EJ, Rufini V, Fragomeni SM, Garganese G, Collarino A. 18F-FDG PET and 18F-FDG PET/CT in vulvar cancer: a systematic review and meta-analysis. Clin Nucl Med. 2021;46:125–32. https://doi.org/10.1097/rlu.0000000000003411.CrossRefPubMed

Bellevre D, Blanc Fournier C, Switsers O, Dugué AE, Levy C, Allouache D, et al. Staging the axilla in breast cancer patients with ¹⁸F-FDG PET: how small are the metastases that we can detect with new generation clinical PET systems? Eur J Nucl Med Mol Imaging. 2014;41:1103–12. https://doi.org/10.1007/s00259-014-2689-7.CrossRefPubMedPubMedCentral

Aide N, Lasnon C, Veit-Haibach P, Sera T, Sattler B, Boellaard R. EANM/EARL harmonization strategies in PET quantification: from daily practice to multicentre oncological studies. Eur J Nucl Med Mol Imaging. 2017;44:17–31. https://doi.org/10.1007/s00259-017-3740-2.CrossRefPubMedPubMedCentral

van der Vos CS, Koopman D, Rijnsdorp S, Arends AJ, Boellaard R, van Dalen JA, et al. Quantification, improvement, and harmonization of small lesion detection with state-of-the-art PET. Eur J Nucl Med Mol Imaging. 2017;44:4–16. https://doi.org/10.1007/s00259-017-3727-z.CrossRefPubMedPubMedCentral

Garganese G, Collarino A, Fragomeni SM, Rufini V, Perotti G, Gentileschi S, et al. Groin sentinel node biopsy and (18)F-FDG PET/CT-supported preoperative lymph node assessment in cN0 patients with vulvar cancer currently unfit for minimally invasive inguinal surgery: the GroSNaPET study. European Journal of Surgical Oncology. 2017;43:1776–83. https://doi.org/10.1016/j.ejso.2017.06.018.CrossRefPubMed

10.

Oonk MH, van Hemel BM, Hollema H, de Hullu JA, Ansink AC, Vergote I, et al. Size of sentinel-node metastasis and chances of non-sentinel-node involvement and survival in early stage vulvar cancer: results from GROINSS-V, a multicentre observational study. Lancet Oncol. 2010;11:646–52. https://doi.org/10.1016/S1470-2045(10)70104-2.CrossRefPubMed

11.

Collarino A, Fuoco V, Garganese G, Pereira Arias-Bouda LM, Perotti G, Manca G, et al. Lymphoscintigraphy and sentinel lymph node biopsy in vulvar carcinoma: update from a European expert panel. Eur J Nucl Med Mol Imaging. 2020;47:1261–74. https://doi.org/10.1007/s00259-019-04650-8.CrossRefPubMed

Title: Is it time to include [18F]FDG-PET/CT in the diagnostic work-up for lymph node staging in cN0 vulvar cancer patients?
Authors: Nicolas Aide
Stephanie Markovina
Annamaria Ferrero
Publication date: 01-09-2021
Publisher: Springer Berlin Heidelberg
Keywords: Vulvar Cancer
Vulvar Cancer
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 10/2021
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-021-05317-z

At a glance: The STEP trials

Springer Medicine

Is it time to include [¹⁸F]FDG-PET/CT in the diagnostic work-up for lymph node staging in cN0 vulvar cancer patients?

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

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