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Chinese Medicine
Published in: Chinese Medicine 1/2020

01-12-2020 | Vulgar Psoriasis | Research

Analysis of microRNA expression in peripheral blood monocytes of three Traditional Chinese Medicine (TCM) syndrome types in psoriasis patients

Authors: Yue Lu, Yao Qi, Yuhong Yan, Danni Yao, Hao Deng, Jingwen Deng, Shuyan Ye, Haiming Chen, Qubo Chen, Hengjun Gao, Ling Han, Chuanjian Lu

Published in: Chinese Medicine | Issue 1/2020

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Abstract

Background

To analyze the expression of miRNA (microRNA) in peripheral blood mononuclear cells in patients with Psoriasis vulgaris with different TCM syndromes by miRNA chip. It further revealed the micromaterial basis of different syndrome types of psoriasis at the miRNA level.

Methods

Peripheral blood monocytes were collected and prepared from 30 patients with Psoriasis vulgaris (including 9 patients of blood heat syndrome, 8 patients of blood stasis syndrome, and 13 patients of blood dry syndrome) and 9 healthy controls. The miRNA expression profile of peripheral blood monocytes was detected by Agilent Hum miRNA chip.

Results

Compared to the healthy control group, 156 upregulated and 242 downregulated miRNAs were detected in all psoriasis patients. Compared to the healthy control group, 40 miRNAs were upregulated and 44 were downregulated in the blood heat syndrome group. Furthermore, there were 49 upregulated miRNAs and 44 downregulated miRNAs in the dry syndrome group as compared to the healthy control group. Also, 67 miRNAs were upregulated and 154 miRNAs were downregulated in the blood stasis syndrome group as compared to the healthy control group.

Conclusions

There are common different miRNAs and pathways, as well as specific miRNAs between the psoriasis and the healthy control groups.
Trial registration ChiCTR-TRC-14005185 registered on August 8, 2014.
Literature
1.
World Health Organization. Global report on psoriasis. Geneva: WHO; 2016. p. 7–9.
2.
Lu CJ, Zeng Z, Xie XL, Ning J. Distribution of Chinese Medical Syndrome in ordinary psoriasis: literature from 1979 to 2010. J Tradit Chin Med. 2012;53(11):959–61 (Article in Chinese).
3.
Yan YH, Lu CJ, Yao DN, Du H, Li HL. Study on the correlation between the basic Syndrome of traditional Chinese Medicine and the stage and condition of Psoriasis vulgaris. J Guangzhou Univ Tradit Chin Med. 2012;04:22–6 (Article in Chinese).
4.
Li XH, Jia LL, Liu XX. Preliminary discussion of diagnosis and treatment mode of future medicine from treating based on syndrome differentiation and precision medicine. Chin J Tradit Chin Med. 2018;33(11):4789–92 (Article in Chinese).
5.
6.
Lu CJ, Yu JJ, Deng JW. Disease-syndrome combination clinical study of psoriasis: present status, advantages, and prospects. Chin J Integrat Med. 2012;18(3):166–71.CrossRef
7.
Xuan L, Luan G, Wang Y, Lan F, Zhang X, Hao Y, et al. MicroRNAs regulating mucin type O-glycan biosynthesis and transforming growth factor beta signaling pathways in nasal mucosa of patients with chronic rhinosinusitis with nasal polyps in Northern China. Int Forum Allergy Rhinol. 2019;9(1):106–13.PubMedCrossRef
8.
Li P, Teng F, Gao F, Zhang M, Wu J, Zhang C. Identification of circulating microRNAs as potential biomarkers for detecting acute ischemic stroke. Cell Mol Neurobiol. 2015;35(3):433–47.PubMedCrossRef
9.
Bononi I, Comar M, Puozzo A, Stendardo M, Boschetto P, Orecchia S, et al. Circulating microRNAs found dysregulated in ex-exposed asbestos workers and pleural mesothelioma patients as potential new biomarkers. Oncotarget. 2016;7(50):82700–11.PubMedPubMedCentralCrossRef
10.
Yang C, Lv K, Chen B, Yang Y, Ai X, Yu H, et al. miR144-3p inhibits PMVECs excessive proliferation in angiogenesis of hepatopulmonary syndrome via Tie2. Exp Cell Res. 2018;365(1):24–32.PubMedCrossRef
11.
Sun X, Liu D, Xue Y, Hu X. Enforced miR-144-3p expression as a non-invasive biomarker for the acute myeloid leukemia patients mainly by targeting NRF2. Clin Lab. 2017;63(4):679–87.PubMed
12.
Chikh A, Matin RN, Senatore V, Hufbauer M, Lavery D, Raimondi C, et al. iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia. EMBO J. 2011;30(20):4261–73.PubMedPubMedCentralCrossRef
13.
Schneider MR, Samborski A, Bauersachs S, Zouboulis CC. Differentially regulated microRNAs during human sebaceous lipogenesis. J Dermatol Sci. 2013;70(2):88–93.PubMedCrossRef
14.
Wu J, Gong H, Bai Y, Zhang W. Analyzing the miRNA-Gene Networks to Mine the Important miRNAs under Skin of Human and Mouse. Biomed Res Int. 2016;2016:5469371.PubMedPubMedCentral
15.
Gu W, An J, Ye P, Zhao KN, Antonsson A. Prediction of conserved microRNAs from skin and mucosal human papillomaviruses. Arch Virol. 2011;156(7):1161–71.PubMedCrossRef
16.
Abue M, Yokoyama M, Shibuya R, Tamai K, Yamaguchi K, Sato I, et al. Circulating miR-483-3p and miR-21 is highly expressed in plasma of pancreatic cancer. Int J Oncol. 2015;46(2):539–47.PubMedCrossRef
17.
Wang C, Sun Y, Wu H, Yu S, Zhang L, Meng Y, et al. Elevated miR-483-3p expression is an early event and indicates poor prognosis in pancreatic ductal adenocarcinoma. Tumour Biol. 2015;36(12):9447–56.PubMedCrossRef
18.
Sand M, Skrygan M, Sand D, Georgas D, Hahn SA, Gambichler T, et al. Expression of microRNAs in basal cell carcinoma. Br J Dermatol. 2012;167(4):847–55.PubMedCrossRef
19.
Wang XL, Zhang T, Wang J, Zhang DB, Zhao F, Lin XW, et al. MiR-378b promotes differentiation of keratinocytes through NKX3.1. PLoS ONE. 2015;10(8):e0136049.PubMedPubMedCentralCrossRef
20.
21.
Harding A, Cortez-Toledo E, Magner NL, Beegle JR, Coleal-Bergum DP, Hao D, et al. Highly efficient differentiation of endothelial cells from pluripotent stem cells requires the MAPK and the PI3K pathways. Stem Cells. 2017;35(4):909–19.PubMedCrossRef
22.
Zhang M, Zhang X. The role of PI3K/AKT/FOXO signaling in psoriasis. Arch Dermatol Res. 2019;311(2):83–91.PubMedCrossRef
23.
Lu Y, Wang AL, Zhang JW, Li L, Wei JA, Li L, et al. PSORI-CM02 ameliorates psoriasis in vivo and in vitro by inducing autophagy via inhibition of the PI3K/Akt/mTOR pathway. Phytomedicine. 2019;64:153054.CrossRef
24.
Said A, Bock S, Lajqi T, Muller G, Weindl G. Chloroquine promotes IL-17 production by CD4 + T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells. J Immunol. 2014;193(12):6135–43.PubMedCrossRef
25.
26.
Rajawat Y, Hilioti Z, Bossis I. Autophagy: a target for retinoic acids. Autophagy. 2010;6(8):1224–6.PubMedCrossRef
27.
Anguiano J, Garner TP, Mahalingam M, Das BC, Gavathiotis E, Cuervo AM. Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives. Nat Chem Biol. 2013;9(6):374–82.PubMedPubMedCentralCrossRef
28.
Yang Y, Wang H, Wang S, Xu M, Liu M, Liao M, et al. GSK3beta signaling is involved in ultraviolet B-induced activation of autophagy in epidermal cells. Int J Oncol. 2012;41(5):1782–8.PubMedPubMedCentralCrossRef
29.
Eckert RL, Efimova T, Dashti SR, Balasubramanian S, Deucher A, Crish JF, et al. Keratinocyte survival, differentiation, and death: many roads lead to mitogen-activated protein kinase. J Investig Dermatol Symp Proc. 2002;7(1):36–40.PubMedCrossRef
30.
Roux PP, Blenis J. ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol Mol Biol Rev. 2004;68(2):320–44.PubMedPubMedCentralCrossRef
31.
Zarubin T, Han J. Activation and signaling of the p38 MAP kinase pathway. Cell Res. 2005;15(1):11–8.PubMedCrossRef
32.
Kanemaru K, Nakamura Y, Totoki K, Fukuyama T, Shoji M, Kaneko H, et al. Phospholipase Cdelta1 regulates p38 MAPK activity and skin barrier integrity. Cell Death Differ. 2017;24(6):1079–90.PubMedPubMedCentralCrossRef
33.
Zhang C, Xiao C, Dang E, Cao J, Zhu Z, Fu M, et al. CD100-Plexin-B2 promotes the inflammation in psoriasis by activating NF-kappaB and the inflammasome in keratinocytes. J Invest Dermatol. 2018;138(2):375–83.PubMedCrossRef
34.
Conrad C, Gilliet M. Psoriasis: from pathogenesis to targeted therapies. Clin Rev Allergy Immunol. 2018;54(1):102–13.PubMedCrossRef
35.
Lewis BJ, Rajpara S, Haggart AM, Wilson HM, Barker RN, Ormerod AD. Predominance of activated, clonally expanded T helper type 17 cells within the CD4+ T cell population in psoriatic lesions. Clin Exp Immunol. 2013;173(1):38–46.PubMedPubMedCentralCrossRef
36.
Zhao L, Xia J, Wang X, Xu F. Transcriptional regulation of CCL20 expression. Microbes Infect. 2014;16(10):864–70.PubMedCrossRef
37.
Kazama M, Umezawa Y, Itoh M, Nobeyama Y, Ito T, Kikuchi S, et al. Successful treatment of ustekinumab in a psoriasis patient with human T-cell leukemia/lymphotropic virus type 1 infection. J Dermatol. 2017;44(11):1334–5.PubMedCrossRef
38.
Raimondo A, Lembo S, Di Caprio R, Donnarumma G, Monfrecola G, Balato N, et al. Psoriatic cutaneous inflammation promotes human monocyte differentiation into active osteoclasts, facilitating bone damage. Eur J Immunol. 2017;47(6):1062–74.PubMedCrossRef
Metadata
Title
Analysis of microRNA expression in peripheral blood monocytes of three Traditional Chinese Medicine (TCM) syndrome types in psoriasis patients
Authors
Yue Lu
Yao Qi
Yuhong Yan
Danni Yao
Hao Deng
Jingwen Deng
Shuyan Ye
Haiming Chen
Qubo Chen
Hengjun Gao
Ling Han
Chuanjian Lu
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Chinese Medicine / Issue 1/2020
Electronic ISSN: 1749-8546
DOI
https://doi.org/10.1186/s13020-020-00308-y

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