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Archives of Dermatological Research
Published in: Archives of Dermatological Research 9/2023

09-08-2023 | Voriconazole | ORIGINAL PAPER

Posaconazole and risk of cutaneous squamous cell carcinoma after lung transplantation: a single institution, retrospective cohort study

Authors: Lawrence F. Kuklinski, Alexandra M. Klomhaus, Amy Shen, Natalie Achamallah, Teresa T. Soriano, Rajan Saggar, Stephen S. Weigt

Published in: Archives of Dermatological Research | Issue 9/2023

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Excerpt

The use of voriconazole as an antifungal prophylaxis after lung transplantation has shown positive outcomes [1]. However, it is also associated with an increased risk of post-transplant cutaneous squamous cell carcinoma (SCC). Posaconazole has emerged as a potential alternative, with anecdotal evidence suggesting a lower incidence of SCC compared to voriconazole [2]. This study aims to investigate the risk of post-transplant SCC among lung transplant recipients receiving different antifungal prophylaxis regimens. …
Literature
1.
Neoh CF, Snell FI, Levvey B, Kotsimbos T, Morrissey CO, Slavin MA et al (2013) Preemptive treatment with voriconazole in lung transplant recipients. Transpl Infect Dis 15(4):344–353CrossRefPubMed
2.
Jacobsen AA, Papo YB, Sarro R, Weisse K, Strasswimmer J (2016) Posaconazole substitution for voriconazole-associated phototoxic effects. JAMA Dermatol 152(7):839–841CrossRefPubMed
3.
Kolaitis NA, Duffy E, Zhang A, Lo M, Barba DT, Chen M et al (2017) Voriconazole increases the risk for cutaneous squamous cell carcinoma after lung transplantation. Transpl Int 30(1):418CrossRef
4.
Kuklinski LF, Li S, Karagas MR, Weng WK, Kwong BY (2017) Effect of voriconazole on risk of nonmelanoma skin cancer after hematopoietic cell transplantation. J Am Acad Dermatol 77(4):706–713CrossRefPubMedPubMedCentral
5.
Tang H, Shi W, Song Y, Han J (2019) Voriconazole exposure and risk of cutaneous squamous cell carcinoma among lung or hematopoietic cell transplant patients: a systematic review and meta analysis. J Am Acad Dermatol 80(2):500–507CrossRefPubMed
Metadata
Title
Posaconazole and risk of cutaneous squamous cell carcinoma after lung transplantation: a single institution, retrospective cohort study
Authors
Lawrence F. Kuklinski
Alexandra M. Klomhaus
Amy Shen
Natalie Achamallah
Teresa T. Soriano
Rajan Saggar
Stephen S. Weigt
Publication date
09-08-2023
Publisher
Springer Berlin Heidelberg
Published in
Archives of Dermatological Research / Issue 9/2023
Print ISSN: 0340-3696
Electronic ISSN: 1432-069X
DOI
https://doi.org/10.1007/s00403-023-02699-y

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