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Published in: Irish Journal of Medical Science (1971 -) 3/2018

01-08-2018 | Original Article

Vitamin D supplementation in pregnancy—a survey of compliance with recommendations

Authors: C. M. Windrim, D. A. Crosby, K. Mitchell, C. Brophy, R. Mahony, M. Higgins

Published in: Irish Journal of Medical Science (1971 -) | Issue 3/2018

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Abstract

Background

Vitamin D deficiency in pregnancy has important maternal and fetal implications, with increased risk of developing gestational diabetes, preeclampsia, preterm birth and small for gestational age birthweight. It is recommended that every pregnant woman should take 5 μg (200 IU) of vitamin D per day during pregnancy and lactation.

Aims

This study aimed to determine the prevalence of women taking vitamin D supplementation and to identify the reasons for patients not taking supplementation within women attending an antenatal clinic in Dublin.

Methods

Survey of women attending the antenatal clinic of the National Maternity Hospital Dublin during 2 weeks in January 2017. Women were asked to record demographics, medical comorbidities and use of vitamin D supplementation or any other supplements in pregnancy, as well as reasons for non-use if appropriate.

Results

Three hundred women were invited to participate and 175 completed the questionnaire (58%). Overall, 38.9% (n = 68) reported to be taking vitamin D supplementation. Of the women that reported not to be taking vitamin D supplementation, 57.9% (n = 62) were taking a pregnancy multivitamin that contained vitamin D, and 28.0% (n = 30) did not know that it was recommended in pregnancy. Therefore, a total of 45 women (25.7%) in our cohort were taking no vitamin D supplementation during pregnancy. There was no difference in non-use based on maternal age, BMI, parity, or country of origin.

Conclusions

Of the women surveyed, 74.3% reported supplementation with vitamin D, either knowingly or unknowingly. Public health initiatives need to utilize this relatively safe, low-cost intervention to maximize maternal and fetal health. This could reduce the rates of antenatal conditions with associated high morbidity and healthcare burden such as gestational diabetes and preeclampsia.
Literature
1.
go back to reference McGowan CA, Byrne J, Walsh J, McAuliffe FM, Vitamin D (2011) Intakes among pregnant women. Eur J Clin Nutr 65:1076–1078CrossRefPubMed McGowan CA, Byrne J, Walsh J, McAuliffe FM, Vitamin D (2011) Intakes among pregnant women. Eur J Clin Nutr 65:1076–1078CrossRefPubMed
2.
go back to reference Dawodu A, Agarwal M, Hossain M, Kochiyil J, Zayed R, Hypovitaminosis D (2003) Vitamin D deficiency in exclusively breastfeeding infants and their mothers in summer: a justification for vitamin D supplementation of breast-feeding infants. J Pediatr 142:169–173CrossRefPubMed Dawodu A, Agarwal M, Hossain M, Kochiyil J, Zayed R, Hypovitaminosis D (2003) Vitamin D deficiency in exclusively breastfeeding infants and their mothers in summer: a justification for vitamin D supplementation of breast-feeding infants. J Pediatr 142:169–173CrossRefPubMed
4.
go back to reference Hill TR, O’Brien MM, Cashman KD, Flynn A, Kiely M (2004) Vitamin D intakes in 18-64-y-old Irish adults. Eur J Clin Nutr 58:1509–1517CrossRefPubMed Hill TR, O’Brien MM, Cashman KD, Flynn A, Kiely M (2004) Vitamin D intakes in 18-64-y-old Irish adults. Eur J Clin Nutr 58:1509–1517CrossRefPubMed
5.
go back to reference O’Riordan MN, Kiely M, Higgins JR, Cashman KD (2008) Prevalence of suboptimal vitamin D status during pregnancy. Ir Med J 101:240–243PubMed O’Riordan MN, Kiely M, Higgins JR, Cashman KD (2008) Prevalence of suboptimal vitamin D status during pregnancy. Ir Med J 101:240–243PubMed
7.
go back to reference Holick MF, Garabedian M (2006) Vitamin D: photobiology, metabolism, mechanism of action, and clinical applications. In: Fa- vus MJ (ed) Primer on the metabolic bone diseases and disorders of mineral metabolism, 6th edn. American Society for Bone and Mineral Research, Washington, DC, pp 129–137 Holick MF, Garabedian M (2006) Vitamin D: photobiology, metabolism, mechanism of action, and clinical applications. In: Fa- vus MJ (ed) Primer on the metabolic bone diseases and disorders of mineral metabolism, 6th edn. American Society for Bone and Mineral Research, Washington, DC, pp 129–137
8.
go back to reference Bouillon R, Vitamin D (2001) From photosynthesis, metabolism, and action to clinical applications. In: DeGroot LJ, Jameson JL (eds) Endocrinology. W.B. Saunders, Philadelphia, pp 1009–1028 Bouillon R, Vitamin D (2001) From photosynthesis, metabolism, and action to clinical applications. In: DeGroot LJ, Jameson JL (eds) Endocrinology. W.B. Saunders, Philadelphia, pp 1009–1028
9.
10.
go back to reference Gorham ED, Garland CF, Garland FC et al (2005) Vitamin D and prevention of colorectal cancer. J Steroid Biochem Mol Biol 97:179–194CrossRefPubMed Gorham ED, Garland CF, Garland FC et al (2005) Vitamin D and prevention of colorectal cancer. J Steroid Biochem Mol Biol 97:179–194CrossRefPubMed
11.
go back to reference Giovannucci E, Liu Y, Rimm EB et al (2006) Prospective study of predictors of vitamin D status and cancer incidence and morality in men. J Natl Cancer Inst 98:451–459CrossRefPubMed Giovannucci E, Liu Y, Rimm EB et al (2006) Prospective study of predictors of vitamin D status and cancer incidence and morality in men. J Natl Cancer Inst 98:451–459CrossRefPubMed
13.
go back to reference Zittermann A, Vitamin D (2006) Disease prevention with special reference to cardiovascular disease. Prog Biophys Mol Biol 92:39–48CrossRefPubMed Zittermann A, Vitamin D (2006) Disease prevention with special reference to cardiovascular disease. Prog Biophys Mol Biol 92:39–48CrossRefPubMed
14.
go back to reference Hypponen E, Laara E, Reunanen A, Jarvelin M-R, Virtanen SM (2001) Intake of vita min D and risk of type 1 diabetes: a birth-cohort study. Lancet 358:1500–1503CrossRefPubMed Hypponen E, Laara E, Reunanen A, Jarvelin M-R, Virtanen SM (2001) Intake of vita min D and risk of type 1 diabetes: a birth-cohort study. Lancet 358:1500–1503CrossRefPubMed
15.
go back to reference Cantorna MT, Zhu Y, Froicu M, Wittke A (2004) Vitamin D status, 1,25-dihydroxyvita min D3, and the immune system. Am J Clin Nutr 80(6Suppl):1717S–1720SCrossRefPubMed Cantorna MT, Zhu Y, Froicu M, Wittke A (2004) Vitamin D status, 1,25-dihydroxyvita min D3, and the immune system. Am J Clin Nutr 80(6Suppl):1717S–1720SCrossRefPubMed
16.
go back to reference Burris HH, Rifas-Shiman SL, Kleinman K et al (2012) Vitamin D deficiency in pregnancy and gestational diabetes mellitus. Am J Obstet Gynecol 207:182.e1–182.e8CrossRef Burris HH, Rifas-Shiman SL, Kleinman K et al (2012) Vitamin D deficiency in pregnancy and gestational diabetes mellitus. Am J Obstet Gynecol 207:182.e1–182.e8CrossRef
17.
go back to reference Robinson CJ, Wagner CL, Hollis BW et al (2011) Maternal vitamin D and fetal growth in early onset severe preeclampsia. Am J Obstet Gynecol 204:556e1–556e4CrossRef Robinson CJ, Wagner CL, Hollis BW et al (2011) Maternal vitamin D and fetal growth in early onset severe preeclampsia. Am J Obstet Gynecol 204:556e1–556e4CrossRef
18.
go back to reference Wei SQ, Audibert F, Hidiroglou N et al (2012) Longitudinal vitamin D status in pregnancy and the risk of preeclampsia. BJOG 119:832–839CrossRefPubMed Wei SQ, Audibert F, Hidiroglou N et al (2012) Longitudinal vitamin D status in pregnancy and the risk of preeclampsia. BJOG 119:832–839CrossRefPubMed
19.
go back to reference Wei SQ, Qi HP, Luo ZC, Fraser W (2013) Maternal vitamin D status and adverse pregnancy outcomes: a systematic review and meta-analysis. J Matern Fetal Neonatal Med 26(9):889–899CrossRefPubMed Wei SQ, Qi HP, Luo ZC, Fraser W (2013) Maternal vitamin D status and adverse pregnancy outcomes: a systematic review and meta-analysis. J Matern Fetal Neonatal Med 26(9):889–899CrossRefPubMed
20.
go back to reference Leffelaar E, Vrijkotte T, Eijsden M (2010) Maternal early pregnancy vitamin D status in relation to fetal and neonatal grwoth: results of the multi-ethnic Amsterdam born children and their development cohort. Br J Nutr 104:108–117CrossRefPubMed Leffelaar E, Vrijkotte T, Eijsden M (2010) Maternal early pregnancy vitamin D status in relation to fetal and neonatal grwoth: results of the multi-ethnic Amsterdam born children and their development cohort. Br J Nutr 104:108–117CrossRefPubMed
21.
go back to reference Javaid MK, Crozier SR, Harvey NC, Gale CR, Dennison EM, Boucher BJ et al (2006) Princess Anne Hospital Study Group. Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study. Lancet 367:36–43CrossRefPubMed Javaid MK, Crozier SR, Harvey NC, Gale CR, Dennison EM, Boucher BJ et al (2006) Princess Anne Hospital Study Group. Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study. Lancet 367:36–43CrossRefPubMed
22.
go back to reference Sayers A, Tobias JH (2009) Estimated maternal ultraviolet B exposure levels in pregnancy influence skeletal development of the child. J Clin Endocrinol Metab 94(3):765–771CrossRefPubMed Sayers A, Tobias JH (2009) Estimated maternal ultraviolet B exposure levels in pregnancy influence skeletal development of the child. J Clin Endocrinol Metab 94(3):765–771CrossRefPubMed
23.
go back to reference Garcia, Audry H et al (2009) 25-Hydroxyvitamin D concentrations during fetal life and bone health in children aged 6 years: a population-based prospective cohort study. Lancet 5(5):367–376 Garcia, Audry H et al (2009) 25-Hydroxyvitamin D concentrations during fetal life and bone health in children aged 6 years: a population-based prospective cohort study. Lancet 5(5):367–376
24.
go back to reference Gale CR, Robinson SM, Harvey NC, Javaid MK, Jiang B, Martyn CN, Godfrey KM, Cooper C (2008) Maternal vitamin D status during pregnancy and child outcomes. Eur J Clin Nutr 62:68–77CrossRefPubMed Gale CR, Robinson SM, Harvey NC, Javaid MK, Jiang B, Martyn CN, Godfrey KM, Cooper C (2008) Maternal vitamin D status during pregnancy and child outcomes. Eur J Clin Nutr 62:68–77CrossRefPubMed
26.
go back to reference American College of Obstetricians and Gynecologists (2011) Vitamin D: screening and supplementation during pregnancy. Committee opinion no. 495. Obstet Gynaecol 118:197–198CrossRef American College of Obstetricians and Gynecologists (2011) Vitamin D: screening and supplementation during pregnancy. Committee opinion no. 495. Obstet Gynaecol 118:197–198CrossRef
28.
go back to reference van der Meer I, Karamali NS, Boeke AJ et al (2006) High prevalence of vitamin D deficiency in pregnant non-western women in The Hague, Netherlands. Am J Clin Nutr 84:350–353PubMedCrossRef van der Meer I, Karamali NS, Boeke AJ et al (2006) High prevalence of vitamin D deficiency in pregnant non-western women in The Hague, Netherlands. Am J Clin Nutr 84:350–353PubMedCrossRef
29.
go back to reference Holmes V, Barnes MS, Alexander HD, McFaul P, Wallace JM (2009) Vitamin D deficiency and insufficiency in pregnant women: a longitudinal study. Br J Nutr 102:876–881CrossRefPubMed Holmes V, Barnes MS, Alexander HD, McFaul P, Wallace JM (2009) Vitamin D deficiency and insufficiency in pregnant women: a longitudinal study. Br J Nutr 102:876–881CrossRefPubMed
Metadata
Title
Vitamin D supplementation in pregnancy—a survey of compliance with recommendations
Authors
C. M. Windrim
D. A. Crosby
K. Mitchell
C. Brophy
R. Mahony
M. Higgins
Publication date
01-08-2018
Publisher
Springer London
Published in
Irish Journal of Medical Science (1971 -) / Issue 3/2018
Print ISSN: 0021-1265
Electronic ISSN: 1863-4362
DOI
https://doi.org/10.1007/s11845-017-1707-8

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