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Indian Journal of Pediatrics

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01-12-2016 | Original Article

Vitamin D Status in Infants with Two Different Wheezing Phenotypes

Authors: Ali Ozdemir, Dilek Dogruel, Ozlem Yilmaz

Published in: Indian Journal of Pediatrics | Issue 12-13/2016

Abstract

Objective

To investigate vitamin D levels in patients with recurrent wheeze at early ages of childhood.

Methods

In the present cross-sectional study, serum 25-hydroxy vitamin D [25 (OH)D], levels which is known as an indicator of vitamin D adequacy, was examined in infants with three or more wheezing attacks.

Results

A total of 186 infants with recurrent wheezing were included in the study along with 118 healthy control peers. The recurrent wheezing study participants were classified into two groups according to Asthma Predictive Index (API) positivity and compared to control subjects regarding their serum vitamin D status. The API negative group had the lowest mean serum 25 (OH)D level (n = 121; 22.71 ± 10.76 ng/ml) followed by API positive group (n = 65; 24.08 ± 9.02 ng/ml) compared to healthy group (26.24 ± 11.88 ng/ml) (p < 0.05). In addition, higher vitamin D deficiency was observed in infants in API negative group (52.1 %; p < 0.01) and API positive group (38.5 %; p < 0.05) than control group (31.4 %).

Conclusions

Low levels of 25 (OH)D were detected in infants with two different phenotypes of recurrent wheeze. Vitamin D deficiency may play a role in the pathogenesis of infants with recurrent wheezing.

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Title: Vitamin D Status in Infants with Two Different Wheezing Phenotypes
Authors: Ali Ozdemir
Dilek Dogruel
Ozlem Yilmaz
Publication date: 01-12-2016
Publisher: Springer India
Published in: Indian Journal of Pediatrics / Issue 12-13/2016
Print ISSN: 0019-5456
Electronic ISSN: 0973-7693
DOI: https://doi.org/10.1007/s12098-016-2184-1

At a glance: The STEP trials

Springer Medicine

Vitamin D Status in Infants with Two Different Wheezing Phenotypes

Abstract

Objective

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

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