Top

Published in:

01-03-2012 | Original Article

Vitamin D receptor gene polymorphism in children with urinary tract infection

Authors: Sule Aslan, Ipek Akil, Gulcin Aslan, Huseyin Onay, Beyhan Cengiz Ozyurt, Ferda Ozkinay

Published in: Pediatric Nephrology | Issue 3/2012

Abstract

It is known that small alterations leading to different vitamin D receptor (VDR) alleles affect resistance or susceptibility to infections. In this study, we examined VDR gene polymorphisms in urinary tract infections (UTI), which are common and an important cause of morbidity in children and subsequently of renal scar formation. We evaluated 92 patients diagnosed with UTI and 105 children without prior history of UTI as a control group. The VDR gene polymorphisms BsmI, FokI, ApaI, and TaqI were evaluated in patients and controls. BsmI polymorphism genotype distribution was similar between groups. There was a significant difference between groups for FokI (p = 0 < 001); for the ff genotype, the risk of UTI was significantly increased (p < 0.01) ,at 3.94 times higher (odds ratio = 3.94; 95% confidence interval 1.71-9.09). ApaI polymorphism was significantly increased in the control group (p < 0.01) and evaluated as a protective factor. Comparing the TaqI genotype between groups, there was no statistically significant difference, but in both Tt and tt genotypes, there was minimal increased risk of UTI. The results of this study suggest that VDR gene polymorphisms can be important for susceptibility to UTI and renal scar formation. Association between VDR polymorphisms and UTI is in accordance with the understanding of how vitamin D modulates the immune response against infections.

Craig JC (2001) Urinary tract infection: new prospectives on a common disease. Curr Opin Infect Dis 14:309–313PubMedCrossRef

Jahnukainen T, Chen M, Celsi G (2005) Mechanisms of renal damage owing to infection. Pediatr Nephrol 20:1043–1053PubMedCrossRef

Haraoka M, Hang L, Frendeus B, Godaly G, Burdick M, Strieter R, Svanborg C (1999) Neutrophil recruitment and resistance to urinary tract infections. J Infect Dis 180:1220–1229PubMedCrossRef

Cotton SA, Gbadegesin RA, Williams S, Brenchley PEC, Webb NJA (2002) Role of TGF-β in renal parenchymal scarring following childhood urinary tract infection. Kidney Int 61:61–67PubMedCrossRef

Artifoni L, Negrisolo S, Montini G, Zucchetta P, Molinari PP, Cassar W, Destro R, Anglani F, Rigamonti W, Zacchello G, Murer L (2007) Interleukin-8 and CXCR1 receptor functional polymorphisms and susceptibility to acute pyelonephritis. J Urol 177:1102–1106PubMedCrossRef

Dusso AS, Brown AJ, Slatopolsky E (2005) Vitamin D. Am J Physiol Renal Physiol 289:F8–F28PubMedCrossRef

Uitterlinden AG, Fang Y, Van Meurs JB, Pols HA, Van Leeuwen JP (2004) Genetics and biology of vitamin D receptor polymorphisms. Gene 338:143–156PubMedCrossRef

Leandro ACSS, Rocha MA, Cardoso CSA, Bonecini-Almeida MG (2009) Genetic polymorphisms in vitamin D receptor, vitamin D-binding protein, Toll-like receptor 2, nitric oxide synthase 2, and interferon-γ genes and its association with susceptibility to tuberculosis. Braz J Med Biol Res 42:312–322PubMedCrossRef

White JH (2008) Vitamin D signaling, infectious diseases, and regulation of innate immunity. Infect Immun 76:3837–3843PubMedCrossRef

10.

Lewis SJ, Baker I, Smith GD (2005) Meta-analysis of vitamin D receptor polymorphisms and pulmonary tuberculosis risk. Int J Tuberc Lung Dis 9:1174–1177PubMed

11.

Dusso AS, Negrea L, Gunawardhana S, Lopez-Hilker S, Finch J, Mori T, Nishii Y, Slatopolsky E, Brown AJ (1991) On the mechanisms for the selective action of vitamin D analogs. Endocrinology 128:1687–1692PubMedCrossRef

12.

Gibney KB, MacGregor L, Leder K, Torresi J, Marshall C, Ebeling PR, Biggs BA (2008) Vitamin D deficiency is associated with tuberculosis and latent tuberculosis infection in immigrants from sub-Saharan Africa. Clin Infect Dis 46:443–446PubMedCrossRef

13.

Kawarau A, Takeda E, Tanida N, Nakagawa K, Yamamoto H, Sawada K, Okano T (2006) Inhibitory effect of long term 1-alpha-hydroxyvitamin D3 administration on Helicobacter pylori infection. J Clin Biochem Nutr 38:103–106CrossRef

14.

Brook I (2005) Microbiology and antimicrobial management of sinusitis. J Laryngol Otol 119:251–258PubMedCrossRef

15.

Montone KT (2007) Infectious diseases of the head and neck: a review. Am J Clin Pathol 128:35–67PubMedCrossRef

16.

Wolf J, Daley AJ (2007) Microbiological aspects of bacterial lower respiratory tract illness in children: atypical pathogens. Paediatr Respir Rev 8:212–220PubMedCrossRef

17.

Wayse V, Yousafzai A, Mogale K, Filteau S (2004) Association of subclinical vitamin D deficiency with severe acute lower respiratory infection in Indian children under 5 y. Eur J Clin Nutr 58:563–567PubMedCrossRef

18.

Muhe L, Lulseged S, Mason KE, Simoes EAF (1997) Case-control study of the role of nutritional rickets in the risk of developing pneumonia in Ethiopian children. Lancet 349:1801–1804PubMedCrossRef

19.

Laaksi I, Ruohola J-P, Tuohimaa P, Auvinen A, Haataja R, Pihlajamaki H, Ylikomi T (2007) An association of serum vitamin D concentrations <40 nmol/L with acute respiratory tract infection in young Finnish men. Am J Clin Nutr 86:714–717PubMed

20.

Poon AH, Laprice C, Lemire M, Montpetit A, Sinnett D, Schurr E, Hudson TJ (2004) Association of vitamin D receptor genetic variants with susceptibility to asthma and atopy. Am J Respir Crit Care Med 170:967–973PubMedCrossRef

21.

Roth DE, Soto G, Arenas F, Bautista CT, Ortiz J, Rodriguez R, Cabrera L, Gilman RH (2004) Association between vitamin D receptor gene polymorphisms and response to treatment of pulmonary tuberculosis. J Infect Dis 190:920–927PubMedCrossRef

22.

Wilkinson RJ, Llewelyn M, Toossi Z, Patel P, Pasvol G, Lalvani A, Wright D, Latif M, Davidson RN (2000) Influence of vitamin D deficiency and vitamin D receptor polymorphisms on tuberculosis among Gujarati Asians in west London: a case-control study. Lancet 355:618–621PubMedCrossRef

23.

Roth DE, Jones AB, Prosser C, Robinson JL, Vohra S (2008) Vitamin D receptor polymorphisms and the risk of acute lower respiratory tract infection in early childhood. J Infect Dis 197:676–680PubMedCrossRef

24.

Barber Y, Rubio C, Fernández E, Rubio M, Fibla J (2001) Host genetic background at CCR5 chemokine receptor and vitamin D receptor loci and human immunodeficiency virus (HIV) type 1 disease progression among HIV-seropositive injection drug users. J Infect Dis 184:1279–1288PubMedCrossRef

25.

De la Torre MS, Torres C, Nieto G, Vergara S, Carrero AS, Macia J, Pineda JA, Caruz A, Fibla J (2008) Vitamin D receptor gene haplotypes and susceptibility to HIV-1 infection in injection drug users. J Infect Dis 197:405–410PubMedCrossRef

26.

Bellamy R, Ruwende C, Corrah T, Mc Adam KP, Thursz M, Whittle HC, Hill AV (1999) Tuberculosis and chronic hepatitis B virus infection in Africans and variation in the vitamin D receptor gene. J Infect Dis 179:721–724PubMedCrossRef

27.

Fitness J, Tosh K, Hill AVS (2002) Genetics of susceptibility to leprosy. Genes Immun 3:441–453PubMedCrossRef

28.

Roy S, Frodsham A, Saha B, Hazra SK, Mascie-Taylor CG, Hill AV (1999) Association of vitamin D receptor genotype with leprosy type. J Infect Dis 179:187–191PubMedCrossRef

29.

Zasloff M (2007) Antimicrobial peptides, innate immunity, and the normally sterile urinary tract. J Am Soc Nephrol 18:2810–2816PubMedCrossRef

30.

Equils O, Naiki Y, Shapiro AM, Michelsen K, Lu D, Adams J, Jordan S (2006) 1,25-Dihydroxyvitamin D3 inhibits lipopolysaccharide-induced immune activation in human endothelial cells. Clin Exp Immunol 143:58–64PubMedCrossRef

31.

Gombart AF, Borregaard N, Koeffler HP (2005) Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3. FASEB J 19:1067–1077PubMedCrossRef

Title: Vitamin D receptor gene polymorphism in children with urinary tract infection
Authors: Sule Aslan
Ipek Akil
Gulcin Aslan
Huseyin Onay
Beyhan Cengiz Ozyurt
Ferda Ozkinay
Publication date: 01-03-2012
Publisher: Springer-Verlag
Published in: Pediatric Nephrology / Issue 3/2012
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-011-2000-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Vitamin D receptor gene polymorphism in children with urinary tract infection

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 3/2012

Correction to: “Severe hypertension in children and adolescents: pathophysiology and treatment”

Tandem plasma-exchange and haemodialysis in a paediatric dialysis unit

Dyslipidemia in children with CKD: should we treat with statins?

Development of common variable immunodeficiency in IgA- and IgG2-deficient patients with systemic lupus erythematosus

Erratum to: Epidemiology of chronic kidney disease in children

Posterior reversible encephalopathy syndrome in children with kidney diseases