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01-08-2005 | Review

Mechanisms of renal damage owing to infection

Authors: Timo Jahnukainen, Ming Chen, Gianni Celsi

Published in: Pediatric Nephrology | Issue 8/2005

Abstract

Urinary tract infection (UTI) is a common bacterial illness in children. It is known to be associated with an increased risk of permanent renal cell damage and scarring which may lead to generation of pathological conditions such as hypertension, pre-eclampsia during pregnancy, renal insufficiency, and end-stage kidney disease. The pathophysiology of renal scarring is still obscure, which makes the prevention of renal damage difficult. During acute infection, there are numerous factors that may contribute to tissue damage. Inflammatory responses are activated by host defense mechanisms as well as by specific bacterial virulence factors. Understanding of these complex mechanisms would be helpful to better identify children at high risk of developing renal scarring following UTI.

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Title: Mechanisms of renal damage owing to infection
Authors: Timo Jahnukainen
Ming Chen
Gianni Celsi
Publication date: 01-08-2005
Publisher: Springer-Verlag
Published in: Pediatric Nephrology / Issue 8/2005
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-005-1898-5

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Mechanisms of renal damage owing to infection

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