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The journal of nutrition, health & aging
Published in: The journal of nutrition, health & aging 9/2018

01-11-2018

Vitamin D Binding Protein and Vitamin D Levels in Multi-Ethnic Population

Authors: Reshma A. Merchant, R. M. van Dam, L. W. L. Tan, M. Y. Lim, J. L. Low, J. E. Morley

Published in: The journal of nutrition, health & aging | Issue 9/2018

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Abstract

Introduction

Low levels of 25-hydroxyvitamin D (25(OH)D) has been associated with many negative health outcomes including falls and fractures. 25(OH)D is largely bound to vitamin D binding protein (VDBP). There is increasing evidence that free or bioavailable 25(OH)D may be a better measure of vitamin D deficiency.

Objective

To determine the prevalence of 25(OH)D deficiency and VDBP levels in multi-ethnic population, and its impact on muscle strength.

Design and methods

Cross-sectional study of older adults in Western region of Singapore. 295 participants from three ethnic groups were selected from the Healthy Older People Everyday (HOPE) cohort for measurements of total 25(OH)D and VDBP levels. Total 25(OH)D, VDBP, frailty status, Timed-Up-and-Go (TUG) and grip strength (GS) were assessed. Albumin, free and bioavailable 25(OH)D were only available for 256 participants.

Results

53% of Malay and 55% of Indians were deficient in 25(OH)D compared with 18.2% of ethnic Chinese participants. Chinese also had higher total 25(OH)D concentrations with a mean of 29.1 ug/l, (p = <0.001). Chinese had the lowest level of VDBP (169.6ug/ml) followed by Malay (188.8 ug/ml) and Indian having the highest (220.1 ug/ml). Calculated bioavailable and free 25(OH)D levels were significantly higher in Chinese, followed by Malays and Indians, which also correlated with better grip strength measures amongst the Chinese.

Conclusion

The Malays and Indians had overall lower free, bioavailable and total 25(OH)D compared with ethnic Chinese. Chinese ethnic group also had the lowest VDBP and better overall grip strength.
Appendix
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Metadata
Title
Vitamin D Binding Protein and Vitamin D Levels in Multi-Ethnic Population
Authors
Reshma A. Merchant
R. M. van Dam
L. W. L. Tan
M. Y. Lim
J. L. Low
J. E. Morley
Publication date
01-11-2018
Publisher
Springer Paris
Published in
The journal of nutrition, health & aging / Issue 9/2018
Print ISSN: 1279-7707
Electronic ISSN: 1760-4788
DOI
https://doi.org/10.1007/s12603-018-1114-5

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