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Journal of Assisted Reproduction and Genetics
Published in: Journal of Assisted Reproduction and Genetics 3/2015

01-03-2015 | Review

Vitamin D and assisted reproduction: should vitamin D be routinely screened and repleted prior to ART? A systematic review

Authors: Michelle M. Pacis, Chelsea N. Fortin, Shvetha M. Zarek, Sunni L. Mumford, James H. Segars

Published in: Journal of Assisted Reproduction and Genetics | Issue 3/2015

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Abstract

Purpose

To review the current literature regarding the role of vitamin D status in pregnancy outcomes in women undergoing assisted reproductive technology (ART) and to assess cost-effectiveness of routine vitamin D deficiency screening and repletion prior to initiation of ART.

Methods

A systematic literature review was conducted using PubMed. Relevant study outcomes were compared among the selected studies. A cost-benefit analysis was performed using a decision tree mathematical model with sensitivity analyses from the perspective of direct societal cost. Published data were used to estimate probabilities and costs in 2014 US dollars.

Results

Thirty-four articles were retrieved, of which eight met inclusion criteria. One study demonstrated a negative relationship between vitamin D status and ART outcomes, while two studies showed no association. The remaining five studies concluded that ART outcomes improved after vitamin D repletion.

Conclusion

The majority of reviewed studies reported a decrement in ART outcomes in patients with vitamin D deficiency. Cost-benefit analyses suggested that screening and supplementing vitamin D prior to ART might be cost effective, but further evidence is needed. Given the absence of Level I evidence regarding vitamin D status and ART outcomes, full endorsement of routine vitamin D screening and supplementation prior to ART is premature.
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Metadata
Title
Vitamin D and assisted reproduction: should vitamin D be routinely screened and repleted prior to ART? A systematic review
Authors
Michelle M. Pacis
Chelsea N. Fortin
Shvetha M. Zarek
Sunni L. Mumford
James H. Segars
Publication date
01-03-2015
Publisher
Springer US
Published in
Journal of Assisted Reproduction and Genetics / Issue 3/2015
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI
https://doi.org/10.1007/s10815-014-0407-9

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